Cancer Risks from Arsenic in Drinking Water

Smith, Allan H.; Hopenhayn‐Rich, Claudia; Bates, Michael; Goeden, Helen M.; Hertz‐Picciotto, Irva; Duggan, Heather M.; Wood, Rose; Kosnett, Michael J.; Smith, Martyn T.

doi:10.2307/3431362

Cited by 159 publications

(111 citation statements)

References 35 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…Fps1p ͉ GlpF ͉ acute promyelocytic leukemia T he U.S. Environmental Protection Agency has classified arsenic as a human carcinogen (1). Conversely trivalent arsenic is an effective chemotherapeutic agent for the treatment of acute promyelocytic leukemia (2).…”

mentioning

confidence: 99%

Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9

Liu

Shen

Carbrey

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

459

298

View full text Add to dashboard Cite

Much is known about the transport of arsenite and antimonite into microbes, but the identities of mammalian transport proteins are unknown. The Saccharomyces cerevisiae FPS1 gene encodes a membrane protein homologous to the bacterial aquaglyceroporin GlpF and to mammalian aquaglyceroporins AQP7 and AQP9. Fps1p mediates glycerol uptake and glycerol efflux in response to hypoosmotic shock. Fps1p has been shown to facilitate uptake of the metalloids arsenite and antimonite, and the Escherichia coli homolog, GlpF, facilitates the uptake and sensitivity to metalloid salts. In this study, the ability of mammalian aquaglyceroporins AQP7 and AQP9 to substitute for the yeast Fps1p was examined. The fps1⌬ strain of S. cerevisiae exhibits increased tolerance to arsenite and antimonite compared to a wild-type strain. Introduction of a plasmid containing AQP9 reverses the metalloid tolerance of the deletion strain. AQP7 was not expressed in yeast. The fps1⌬ cells exhibit reduced transport of 73 As(III) or 125 Sb(III), but uptake is enhanced by expression of AQP9. Xenopus laevis oocytes microinjected with either AQP7 or AQP9 cRNA exhibited increased transport of 73 As(III). These results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenite as a human toxin and carcinogen, as well as its efficacy as a chemotherapeutic agent for acute promyelocytic leukemia.Fps1p ͉ GlpF ͉ acute promyelocytic leukemia

show abstract

mentioning

confidence: 99%

Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9

Liu

Shen

Carbrey

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

459

298

View full text Add to dashboard Cite

show abstract

“…Cancer effects 14 are in a similar way than in other well documented environmental As exposures of Taiwan 15 , India, Bangladesh, USA 16 , Mexico 17 , Argentina and Hungary 18 -22 ; different type of cancer, mainly lung and bladder cancer have been reported as main problems As associated diseases. According Smith et al 23 , the impact of As on the population mortality in the II Region of Chile is greater than that reported anywhere to date from environmental exposure to carcinogen in a major population; dose -response relation between As concentration in well water and mortality from cancers has been characterized 12,24 .…”

Section: Introductionmentioning

confidence: 71%

TOTAL AND MAIN As SPECIES PRESENT IN CARDIOVASCULAR TISSUES OF PEOPLE LIVINGIN As CONTAMINATED AREAS

Pizarro

Roman-Silva

Solar³

et al. 2012

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

The concentration levels of As in the Chilean II Region of Antofagasta produces non cancer health outcomes such as cardiovascular diseases and in last term heart attack. On this study, the determination of total As content and main inorganic and organoarsenic species found in three heart tissues (auricle, mammary artery and fat) and the saphene vein of people living in the Chilean II Region, suffering coronary thrombosis has been carried out. Comparison with similar tissues of patients from other non-contaminated areas has been undertaken.The extraction of As species occurred in methanol: water (1:1) and As species determination have been used the tandem HPLC-ICP-MS using the Hamilton PRP X100 anion column. For total As determination has been performed by HG-AAS and ICP-MS.The auricle and in less extend the saphene support the higher As concentration (mean values of 7.7 and 2.5 µg g -1 , respectively), being As(III) the predominant species. Methylarsonate (MA) and dimethylarsinate (DMA) is not a favoured mechanism.The presence of high total As and high As(III) species content in the auricle and saphene of more contaminated people, the damage found in the saphene tissue and the global characteristics of the people under study in which the As stigmas are present in all of them, suggests that As could be involved in the cardiovascular diseases.

show abstract

“…Nitric acid (double distilled, Seastar Co., Canada) and hydrochloric acid (trace metal grade, Fisher Scientific Co., Canada) were used to prepare 0.2% HNO 3 (v/v) and 0.2% HCl (v/v), respectively, with pure water (Barnstead NANOpure system). A stock standard solution of 1000 mg/l for As(V) (H 3 AsO 4 in 0.5 M HNO 3 ) was purchased from Merck (Germany); As(III) was prepared by dissolving 0.1320 g As 2 O 3 (99.995%, Aldrich, USA) in 10 ml of 4.0%(w/v) NaOH, acidifying with 2.0 ml of conc.…”

Section: Reagents and Solutionsmentioning

confidence: 99%

“…[1][2][3] In the southwest coastal region of Taiwan (Tainan and Chia-I county) 1 , a few residents had for more than 30 years been drinking deep groundwater containing high levels (600 -700 µg/l) of arsenic compounds 4,5 , which caused Blackfoot Disease. Based on this phenomenon, the USEPA and Taiwan government have considered decreasing the allowable contamination levels of total arsenic in drinking water to be 2 -20 µg/l 6 and 10 µg/l, respectively.…”

mentioning

confidence: 99%

Determination of Trace Amounts of Arsenic(III) and Arsenic(V) in Drinking Water and Arsenic(III) Vapor in Air by Graphite-Furnace Atomic Absorption Spectrophotometry Using 2,3-Dimercaptopropane-1-sulfonate as a Complexing Agent

1999

View full text Add to dashboard Cite

Cumulative excess amounts of arsenic in our body may cause liver, lung, kidney, bladder or skin cancers, and chronic poisoning. [1][2][3] In the southwest coastal region of Taiwan (Tainan and Chia-I county) 1 , a few residents had for more than 30 years been drinking deep groundwater containing high levels (600 -700 µg/l) of arsenic compounds 4,5 , which caused Blackfoot Disease. Based on this phenomenon, the USEPA and Taiwan government have considered decreasing the allowable contamination levels of total arsenic in drinking water to be 2 -20 µg/l 6 and 10 µg/l, respectively.As(III) is considered to be more toxic than As(V), which is in turn more toxic than organic arsenics. The 8-h average permissible exposure limit for As 2 O 3 in air was recommended not to exceed 0.01 mg/m 3 of As by OSHA.7 Several methods commonly used for the determination of the amounts of arsenic species in water are flow-injection with graphite-furnace atomic absorption spectrometry (FI-GFAAS) 8 , or with hydride generation atomic absorption spectrometry (FI-HGAAS); 9,10 chelating extraction and then HGAAS 11 , or neutron activation analysis; 12 HPLC and then HGAAS 4 , or HG-ICPMS; 13 and ion chromatography-HG-ICPMS.14 The As 2 O 3 vapor in air determined by NIOSH 7 was collected on a Na 2 CO 3 -impregnated cellulose ester membrane. After digestion and the addition of Ni 2+ , an aliquot (25 µl) was analyzed by GFAAS. The detection limit was 0.06 µg per sample and the linear range was 0.67 -32 µg/m 3 as As for a 400-l sample.2,3-Dimercaptopropane-1-sulfonate (DMPS) has been used as an antidote for mice 15 and human 16 poisoning with sodium arsenite, and Ni 2+ has been commonly used as a chemical modifier in GFAAS 5,17,18 to form a stable compound of NiAs. 19 In this paper, we used DMPS as a complexing agent for As(III) in ammonium acetate buffer of pH 5.5. The complex of As(III)-DMPS was selectively retained on Sep-Pak C 18 cartridges and then concentrated in methanol; while As(V) could not be retained in this way. The As(V) was pre-reduced to As(III) with L-cysteine 9,13,20,21 and the total amount of As(III)+As(V) was determined. The amount of As(V) was obtained by subtracting As(III) from [As(III)+As(V)]. Hence, trace amounts of As(III) (up to 200 ng) and As(V) (up to 100 ng) in drinking water (25 ml) could be accurately determined by GFAAS. The applicability for the determination of As(III) vapor in air was also attempted. Experimental ApparatusA Hitachi Z-8000 graphite-furnace atomic absorption spectrophotometer, equipped with a Zeeman back- Department of Environmental Science, Tunghai University, Taichung 407, Taiwan, Republic of ChinaAs(III) (12.5 -200 ng) in drinking water (25 ml) reacted with 2,3-dimercaptopropane-1-sulfonate (DMPS, 0.60 mg) in ammonium acetate buffer (2.0 mmol, pH 5.5) and formed a complex of As(III)-DMPS. The complex was selectively retained on two Sep-Pak C18 cartridges in series, while As(V) could not be retained. Each cartridge was eluted with methanol (2.00 ml). After addition of Ni 2+ (2.0 mg), a portion ...

show abstract

Cancer Risks from Arsenic in Drinking Water

Cited by 159 publications

References 35 publications

Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9

Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9

TOTAL AND MAIN As SPECIES PRESENT IN CARDIOVASCULAR TISSUES OF PEOPLE LIVINGIN As CONTAMINATED AREAS

Determination of Trace Amounts of Arsenic(III) and Arsenic(V) in Drinking Water and Arsenic(III) Vapor in Air by Graphite-Furnace Atomic Absorption Spectrophotometry Using 2,3-Dimercaptopropane-1-sulfonate as a Complexing Agent

Contact Info

Product

Resources

About