Cancer Risk in Pediatric-Onset Inflammatory Bowel Disease

El‐Matary, Wael; Bernstein, Çharles N.

doi:10.3389/fped.2020.00400

Cited by 10 publications

(7 citation statements)

References 47 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The causal relationships between inflammation and cancer are now widely recognized and discussed. Experimental or epidemiological reports have documented that individuals with inflammatory bowel disease (IBD), for instance ulcerative colitis (UC) and Crohn's disease (CD), are more likely to develop colorectal cancer (CRC) than the general population 1–3 . According to the large meta‐analysis in 2001 by Eaden et al., the risk of cancer progression in patients with IBD is time dependent, which may escalate 2% by 10 years, 8% by 20 years and up to 18% by 30 years 4 .…”

Section: Introductionmentioning

confidence: 99%

PRKAR2A‐derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis‐associated colorectal cancer

Wan

Wang

et al. 2022

Clinical & Translational Med

View full text Add to dashboard Cite

Background Emerging studies have proved that colonic inflammation caused by refractory inflammatory bowel disease (IBD) can initiate the colitis‐associated cancer (CAC), but the transition from inflammation to carcinoma is still largely unknown. Methods In this study, mouse colitis and CAC models were established, and the RNA‐seq by circRNA microarray was employed to identify the differentially expressed circRNAs and mRNAs in different comparisons (DSS vs. NC and AOM/DSS vs. DSS). The bioinformatics analyses were used to search the common characteristics in mouse colitis and CAC. Results The K‐means clustering algorithm packaged these differential expressed circRNAs into subgroup analysis, and the data strongly implied that mmu_circ_0001109 closely correlated to the pro‐inflammatory signals, while mmu_circ_0001845 was significantly associated with the Wnt signalling pathway. Our subsequent data in vivo and in vitro confirmed that mmu_circ_0001109 could exacerbate the colitis by up‐regulating the Jak‐STAT3 and NF‐kappa B signalling pathways, and mmu_circ_0001845 promoted the CAC transformation through the Wnt signalling pathway. By RNA blasting between mice and humans, the human RTEL1‐ and PRKAR2A‐derived circRNAs, which might be considered as homeotic circRNAs of mmu_circ_0001109 and mmu_circ_0001845, respectively, were identified. The clinical data revealed that RTEL1‐derived circRNAs had no clinical significance in human IBD and CAC. However, three PRKAR2A‐derived circRNAs, which had the high RNA similarities to mmu_circ_0001845, were remarkably up‐regulated in CAC tissue samples and promoted the transition from colitis to CAC. Conclusions Our results suggested that these human PRKAR2A‐derived circRNAs could be novel candidates for distinguishing CAC patients and predicted the prognosis of CAC.

show abstract

Section: Introductionmentioning

confidence: 99%

PRKAR2A‐derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis‐associated colorectal cancer

Wan

Wang

et al. 2022

Clinical & Translational Med

View full text Add to dashboard Cite

show abstract

“…Colonic preservation should be considered in this population as many patients with Crohn disease or ulcerative colitis do not progress to colectomy . 12 The use of biologic agents to medically treat IBD has been found to reduce the number of patients requiring colectomies. 13 In the future, clinicians may want to consider evaluation of the rectal function and defecation prior to ileostomy take down given the risk for peristalsis following a bacterial infection and operation.…”

Section: Discussionmentioning

confidence: 99%

A Novel Surgical Treatment of Pediatric Fulminant Clostridium difficile Colitis

Hanson

Wagner

2021

Pediatrics

View full text Add to dashboard Cite

Clostridium difficile associated disease (CDAD), inflammatory bowel disease (IBD), emergency department (ED), white count (WBC), C reactive protein (CRP), intravenous fluids (IVF), hospital day (HD), intensive care unit (ICU), polyethylene glycol (PEG), post-operative day (POD) Article Summary: We report the first pediatric case of the use of diverting loop ileostomy and colonic lavage to treat fulminant Clostridium difficile colitis.

show abstract

“…Thus, it can be challenging to predict which patients will have progression of disease and require colectomy based on phenotypic description at presentation alone. Predictors that identify which treatments will be effective for which patients are critically needed so that patients can achieve rapid and sustained improvement in symptoms and quality of life ( 18 ), normalize growth and development ( 6 ), reduce cumulative exposure to corticosteroids and their associated toxicities, and avoid disease complications including toxic megacolon and colitis-associated colorectal cancer later in life ( 19 , 20 ). Moreover, we wish to consistently use the safest treatment approach that will achieve this goal for any individual patient.…”

Section: Rationale For Precision Medicine In Ucmentioning

confidence: 99%

Predicting Therapeutic Response in Pediatric Ulcerative Colitis—A Journey Towards Precision Medicine

2021

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a disabling disease, characterized by chronic inflammation of the colon, with a rising prevalence worldwide in the pediatric age group. Although UC presents in children with varying severity, disease extent, and comorbidities, initial treatment is essentially uniform, consisting of 5-aminosalicylate drugs with corticosteroid induction for those with moderately to severely active disease. With the advent of anti-tumor necrosis factor (TNF) biologic therapy and several new biologics and small-molecule drugs for UC, precision medicine approaches to treatment are needed to more rapidly achieve sustained remission, restore quality of life, normalize development, and limit exposure to toxic corticosteroids in children with UC. Here, we review available data on clinical, biochemical, histopathologic, and molecular predictors of treatment response in UC. We also address known predictors and special treatment considerations in specific relevant scenarios such as very-early-onset UC, acute severe UC, ileal pouch anal anastomosis, and UC with concomitant primary sclerosing cholangitis. The review concludes with a prediction of how machine learning will integrate multimodal patient data to bring precision medicine to the bedside of children with UC in the future.

show abstract

Cancer Risk in Pediatric-Onset Inflammatory Bowel Disease

Cited by 10 publications

References 47 publications

PRKAR2A‐derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis‐associated colorectal cancer

PRKAR2A‐derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis‐associated colorectal cancer

A Novel Surgical Treatment of Pediatric Fulminant Clostridium difficile Colitis

Predicting Therapeutic Response in Pediatric Ulcerative Colitis—A Journey Towards Precision Medicine

Contact Info

Product

Resources

About