Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis

Hu, Xiaojie; Wang, Xuanyu; Liang, Yue; Chen, Xin; Zhou, Siyuan; Fei, Wenting; Yang, Yuxin; Hua-fa, Que

doi:10.3389/fendo.2022.937871

Cited by 28 publications

(22 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meta-based analysis was applied in this study. Compared with traditional literature review or the emerging bibliometric analysis, systematic review and meta-analysis had a relatively broad horizon of the current hotspots and can quantitatively reflect the research status in the field ( 1 – 3 ). This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines ( 4 ) and is registered with the International Prospective Register of Systematic Reviews (CRD42022339839).…”

Section: Methodsmentioning

confidence: 99%

“…Hashimoto's thyroiditis (HT), also known as autoimmune thyroiditis (AIT) or chronic lymphocytic thyroiditis, is an autoimmune disease of the thyroid gland, often characterized by an enlarged thyroid gland, lymphocytic infiltration, and elevated serum autoimmune antibody levels. HT is a common cause of hypothyroidism in iodine-replete settings and increases the risk of malignancy ( 1 – 3 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: A systematic review and meta-analysis

Chen

Shen

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

ObjectiveAlthough Hashimoto's thyroiditis is associated with cardiovascular disease and malignancy, the global status of Hashimoto's thyroiditis is not well characterized across regions. Our objective was to evaluate the prevalence and trends of Hashimoto's thyroiditis in adults in regions with different economic income levels around the world.MethodsFor this systematic review and meta-analysis, we searched PubMed, Embase, MEDLINE, Scopus, and Web of Science databases, and 48 random-effects representative studies from the inception to June 2022 were included without language restrictions to obtain the overall prevalence of Hashimoto's thyroiditis in adults worldwide. In addition, we stratified by time of publication, geographic region, economic level of the region of residence, gender, diagnostic method, etc.ResultsA total of 11,399 studies were retrieved, of which 48 met the research criteria: 20 from Europe, 16 from Asia, five from South America, three from North America, and three from Africa. Furthermore, there are two projects involving 19 countries and 22,680,155 participants. The prevalence of Hashimoto's thyroiditis was 7.5 (95%CI 5.7–9.6%), while in the low-middle-income group the prevalence was 11.4 (95%CI 2.5–25.2%). Similarly, the prevalence was 5.6 (95%Cl 3.9–7.4%) in the upper-middle-income group, and in the high-income group, the prevalence was 8.4 (95%Cl 5.6–11.8). The prevalence of Hashimoto's varied by geographic region: Africa (14.2 [95% CI 2.5–32.9%]), Oceania (11.0% [95% CI 7.8–14.7%]), South America and Europe 8.0, 7.8% (95% Cl 0.0–29.5%) in North America, and 5.8 (95% Cl 2.8–9.9%) in Asia. Although our investigator heterogeneity was high (I2), our results using a sensitivity analysis showed robustness and reliability of the findings. People living in low-middle-income areas are more likely to develop Hashimoto's thyroiditis, while the group in high-income areas are more likely to develop Hashimoto's thyroiditis than people in upper-middle-income areas, and women's risk is about four times higher than men's.ConclusionsGlobal Hashimoto's thyroiditis patients are about four times as many as males, and there are discrepancies in the regions with different economic levels. In low-middle-income areas with a higher prevalence of Hashimoto's thyroiditis, especially countries in Africa, therefore local health departments should take strategic measures to prevent, detect, and treat Hashimoto's thyroiditis. At the same time, the hidden medical burden other diseases caused by Hashimoto's thyroiditis should also be done well.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD 42022339839.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: A systematic review and meta-analysis

Chen

Shen

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…Conflicting results exist in the literature about the abundance of B cells in PTC (35, 36), stating that they are either enriched or depleted, and the complex nature of the deconvoluted TCGA data hints at the reason for these contradictory results. Previous studies suggest an increased risk of developing thyroid cancer for thyroiditis patients (37, 38) but the exact mechanisms underlying that transition need to be further studied, including the role played by infiltrating immune lymphocytes at the onset and during the progression of the disease.…”

Section: Discussionmentioning

confidence: 99%

Single nuclei and spatial transcriptomes suggest a stratification of papillary and anaplastic thyroid cancer cells

Tourneur,

Rodrigues Vitoria,

Saiselet

et al. 2024

Preprint

View full text Add to dashboard Cite

Sixty percent of papillary thyroid cancers (PTCs) are driven by BRAFV600E, a mutation associated with high inter- and intra-tumoral heterogeneity. PTCs may become highly aggressive anaplastic thyroid cancers (ATC). While single cell transcriptomics may resolve this heterogeneity, it is potentially confounded by batch effects whose correction may dampen inter-tumor variations. We profiled ATCs and BRAFV600E PTCs with single nuclei RNA-seq and spatial transcriptomics, and an experimental design disentangling biological and technical variations. It reveals that much transcriptional variation in cancer cells and several immune cell types is idiosyncratic, i.e. tumor-specific. It is associated in some cases with genomic aberrations and global tissue states like hypoxia. Beyond idiosyncrasies, differentiation markers SLC5A5 (NIS), TPO, TG and TSHR are lost in a sequence mirrored by their gain during human thyroid organoids maturation, suggesting a new classification of cancer cell states. PTC cells retain TSHR expression and show features of partial EMT with a massive expression of FN1, which promotes proliferation via an autocrine loop. In contrast, ATCs undergo full blown EMT, with expression of mesenchymal extracellular components and loss of TSHR. Finally, we show that the microenvironment of cancer cells is driven by inflammation. These findings may help future stratifications of BRAFV600E PTCs.

show abstract

“…Indeed, multiple studies have proposed a relationship between HT and possible malignant transformation involving immunological and endocrinological pathogenic links. Thus, chronic inflammation might function as an important inducer of cellular transformation and tumor progression in the thyroid ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Identifying and analyzing the key genes shared by papillary thyroid carcinoma and Hashimoto’s thyroiditis using bioinformatics methods

et al. 2023

View full text Add to dashboard Cite

BackgroundHashimoto’s thyroiditis (HT) is a chronic autoimmune disease that poses a risk factor for papillary thyroid carcinoma (PTC). The present study aimed to identify the key genes shared by HT and PTC for advancing the current understanding of their shared pathogenesis and molecular mechanisms.MethodsHT- and PTC-related datasets (GSE138198 and GSE33630, respectively) were retrieved from the Gene Expression Omnibus (GEO) database. Genes significantly related to the PTC phenotype were identified using weighted gene co-expression network analysis (WGCNA). Differentially expressed genes (DEGs) were identified between PTC and healthy samples from GSE33630, and between HT and normal samples from GSE138198. Subsequently, functional enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Transcription factors and miRNAs regulating the common genes in PTC and HT were forecasted using the Harmonizome and miRWalk databases, respectively, and drugs targeting these genes were investigated using the Drug-Gene Interaction Database (DGIdb). The key genes in both GSE138198 and GSE33630 were further identified via Receiver Operating Characteristic (ROC) analysis. The expression of key genes was verified in external validation set and clinical samples using quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).ResultsIn total, 690 and 1945 DEGs were associated with PTC and HT, respectively; of these, 56 were shared and exhibited excellent predictive accuracy in the GSE138198 and GSE33630 cohorts. Notably, four genes, Alcohol Dehydrogenase 1B (ADH1B), Active BCR-related (ABR), alpha-1 antitrypsin (SERPINA1), and lysophosphatidic acid receptor 5 (LPAR5) were recognized as key genes shared by HT and PTC. Subsequently, EGR1 was identified as a common transcription factor regulating ABR, SERPINA1, and LPAR5 expression. These findings were confirmed using qRT-PCR and immunohistochemical analysis.ConclusionFour (ADH1B, ABR, SERPINA1, and LPAR5) out of 56 common genes exhibited diagnostic potential in HT and PTC. Notably, this study, for the first time, defined the close relationship between ABR and HT/PTC progression. Overall, this study provides a basis for understanding the shared pathogenesis and underlying molecular mechanisms of HT and PTC, which might help improve patient diagnosis and prognosis.

show abstract

Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis

Cited by 28 publications

References 60 publications

Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: A systematic review and meta-analysis

Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: A systematic review and meta-analysis

Single nuclei and spatial transcriptomes suggest a stratification of papillary and anaplastic thyroid cancer cells

Identifying and analyzing the key genes shared by papillary thyroid carcinoma and Hashimoto’s thyroiditis using bioinformatics methods

Contact Info

Product

Resources

About