Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease

So, Jacqueline; Tang, WM; Leung, Wai Keung; Li, Michael; Lo, Fu Hang; Wong, Margaret Wan Nar; Sze, Alex Shun Fung; Leung, Chi Man; Tsang, Steven Woon Choy; Shan, Edwin Hok Shing; Chan, Kam Hon; Lam, Belsy C Y; Hui, Aric Josun; Chow, Wai Hung; Lam, Tsz Yiu; Lam, Vernon; Lee, Tsz Wai; Lo, Harris Ho Him; Tang, Ching Man; Wong, Cheuk Lau; Wu, Justin C.Y.; Chan, Francis K.L.; Sung, Joseph J.Y.; Harbord, Marcus; Ng, Siew C.

doi:10.1097/mib.0000000000001240

Cited by 55 publications

(75 citation statements)

References 24 publications

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“…Among them, six articles focusing on this topic without required data, seven duplicate articles, and 52 articles focusing on other topics were excluded from the meta-analysis. Then, seven articles were included [ 11 , 13 , 19 – 23 ]. Their references were researched, and no suitable article was found.…”

Section: Resultsmentioning

confidence: 99%

“…Jung et al and So et al reported that 35.3% and 40.0% of the IBD patients separately in their studies received the immunosuppressant, and these two studies were defined as “ever use” studies [ 13 , 19 ]. Sonu et al in their study and our case-control study reported that the IBD patients did not adopt any kind of immunosuppressant before the development of TC, and these studies were defined as “never use” study [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…According to these findings, potential relationship between risk of TC and history of IBD has also been explored. Some studies reported that risk of TC was elevated in patients with IBD [ 10 , 11 ], but other studies failed to do so [ 12 , 13 ]. Thus, a firmed conclusion has not been drawn.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

Cao

2018

World J Surg Onc

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BackgroundPotential risk of thyroid cancer in patients with inflammatory bowel disease has not been well investigated. The aim of the study was to reveal the relationship between history of inflammatory bowel disease and risk of thyroid cancer.MethodsFirst, 1392 patients with inflammatory bowel disease and 1392 controls were included in a case-control study. All patients did not receive immunosuppressive therapy. A multivariate logistic regression analysis was adopted to determine the relationship between history of inflammatory bowel disease and risk of thyroid cancer. Second, a literature search was performed and eight articles were collected. Pooled odds ratios with 95% confidence intervals were reported for relevant risk estimates in fixed or random effect model.ResultsIn the case-control study, thyroid cancer was more common in patients with inflammatory bowel disease than in controls (P = 0.032). After Bonferroni correction, association of thyroid cancer risk with history of total inflammatory bowel disease or its two subtypes was not found. In the meta-analysis, patients with total inflammatory bowel disease or ulcerative colitis showed an increased risk of thyroid cancer, but patients with Crohn’s disease did not. Furthermore, inflammatory bowel disease patients with immunosuppressive therapy showed an increased risk of the cancer, but patients without immunosuppressive therapy did not have this finding.ConclusionsRisk of thyroid cancer probably elevates in patients with inflammatory bowel disease. Inflammatory bowel disease (particularly ulcerative colitis) itself and use of immunosuppressant might contribute to the development of the cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

Cao

2018

World J Surg Onc

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“…The first description of AML in patients with inflammatory bowel disease was reported in 1980, which identified 5 AML cases among 400 ulcerative colitis patients [2]. In a recent population-based study, using a territory-wide registry in Hong Kong, the risk of acute leukemia was found to be almost 6 times higher in Chinese patients with CD than the general population [3]. With a trend of increasing incidence of inflammatory bowel diseases in Asia [3], it is important to assess complications of disease and to include blood cell counts for surveillance of hematological malignancies.…”

Section: Discussionmentioning

confidence: 99%

Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn’s Disease Treated with Immunosuppressive Therapy

Zhu

Long

et al. 2018

Case Rep Oncol

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We report a case of acute myeloid leukemia with myelodysplasia-related changes in a patient with Crohn’s disease. The patient was diagnosed with Crohn’s disease at the age of 47 years and was treated with the tumor necrosis factor α inhibitors adalimumab and infliximab, and a short course of azathioprine. Four years later, the patient developed acute myeloid leukemia with myelodysplasia that involved mainly erythropoiesis. Crohn’s disease is associated with an increased risk of cancers including hematological malignancies. Cancer surveillance including hematology assessment is warranted to monitor the patients on immunosuppressive therapy.

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“…intestinal flora, diet and infection [1][2][3]. Because the disease is prolonged and prone to recurrent episodes, it increases the risk of colon cancer [4,5]. As one of the important interfaces between the body and the external environment, the intestinal mucosal barrier plays a key role in maintaining intestinal homeostasis.…”

mentioning

confidence: 99%

The Combined Effect of Vitamin C and Vitamin D3 on the Intestinal Epithelial Barrier by Regulating Notch Signaling Pathway

Qiu¹,

Zhang²,

Ma³

et al. 2019

Preprint

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Background: Tight junction proteins play crucial role in maintaining the intestinal mucosal barrier. Although previous studies had shown that the Notch signal is closely related to tight junction proteins, the mechanism by which it does so remains unknown. The goal of the present study was to investigate whether vitamin C combined with vitamin D3 affects intestinal mucosal barrier stability through Notch signal pathway.Results: To assess the effect of vitamin C combined with vitamin D3 on the intestinal mucosal barrier, electron microscopic observation of ultrastructure of tight junctions was done. And tight junction proteins gene and Notch signal gene expression were analyzed by quantitative reverse-transcription polymerase chain reaction, expression of tight junction protein in SW480 cells interfered with by LPS were examined by western blot. We found that vitamin C combined with vitamin D3 had protective effect on DSS-induced ulcerative colitis in guinea pig intestinal mucosa. Electron microscopy results showed that both low dose and high dose of vitamin C combined with vitamin D3 could maintain DSS-induced ulcerative colitis in guinea pig intestinal epithelium tight junction, however, the combination of medium dose vitamin C and vitamin D3 did not have this effect; Compared with the control group, the expression level of ZO-1 mRNA in the colon tissue of high-dose vitamin C group was significantly increased. In SW480 cell experiments, compared with the control group, the cell migration and repair ability of different concentrations of vitamin C combined with vitamin D3 group were significantly improved, the protein expression of Notch-1 was increased, but the protein expression of claudin-2 was significantly decreased. Conclusions: our results of this experiment showed that the appropriate amount of vitamin C combined with vitamin D3 might regulate the expression of claudin-2 by regulating Notch-1, slow the intestinal mucosal barrier destruction, and promote the damage repair of cell mucosal barrier.

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Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease

Abstract: In a population-based study, Chinese patients with CD are at an increased risk of anorectal cancers and hematological cancers compared with the general population. A higher risk of nonmelanoma skin cancer was also observed in CD and UC. Cancer surveillance should be considered.

Cited by 55 publications

References 24 publications

Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn’s Disease Treated with Immunosuppressive Therapy

The Combined Effect of Vitamin C and Vitamin D3 on the Intestinal Epithelial Barrier by Regulating Notch Signaling Pathway

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