Cancer risk assessment on trihalomethanes and haloacetic acids in drinking water of China using disability-adjusted life years

Pan, Shenling; An, Wei; Li, Hongyan; Su, Ming; Zhang, Jinliang; Yang, Min

doi:10.1016/j.jhazmat.2014.07.080

Cited by 86 publications

(23 citation statements)

References 35 publications

(51 reference statements)

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“…The average concentrations of trihalomethanes in primary and secondary water samples from the WTPs generally followed the sequence TCM > BDCM > TBM = DBCM, which was consistent with similar documented reports [ 3 , 5 , 45 , 46 ]. The total concentrations of the THMs (TCM + BDCM + TBM + DBCM) in primary water samples ranged from 21.92 to 997.43 μ g/L and 28.25 to 999.64 μ g/L in public and private water treatment plants, respectively.…”

Section: Resultssupporting

confidence: 90%

“…Possible health hazards of drinking water that contains the unregulated DBPs is however on the increase with the nonavailability of nonchlorinated or alternative disinfectants. Several epidemiological studies have reported that health complications, associated with liver, reproductive system, kidney, and central nervous system, increased risk of cancer due to consumption of drinking water that contains DBPs in excess of the maximum contaminant level (MCL) [ 5 , 34 – 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Disinfection Byproducts in Drinking Water and Evaluation of Potential Health Risks of Long-Term Exposure in Nigeria

Benson

Akintokun

Adedapo

2017

Journal of Environmental and Public Health

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Levels of trihalomethanes (THMs) in drinking water from water treatment plants (WTPs) in Nigeria were studied using a gas chromatograph (GC Agilent 7890A with autosampler Agilent 7683B) equipped with electron capture detector (ECD). The mean concentrations of the trihalomethanes ranged from zero in raw water samples to 950 μg/L in treated water samples. Average concentration values of THMs in primary and secondary disinfection samples exceeded the standard maximum contaminant levels. Results for the average THMs concentrations followed the order TCM > BDCM > DBCM > TBM. EPA-developed models were adopted for the estimation of chronic daily intakes (CDI) and excess cancer incidence through ingestion pathway. Higher average intake was observed in adults (4.52 × 10−2 mg/kg-day), while the ingestion in children (3.99 × 10−2 mg/kg-day) showed comparable values. The total lifetime cancer incidence rate was relatively higher in adults than children with median values 244 and 199 times the negligible risk level.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Disinfection Byproducts in Drinking Water and Evaluation of Potential Health Risks of Long-Term Exposure in Nigeria

Benson

Akintokun

Adedapo

2017

Journal of Environmental and Public Health

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“…The significance of the three exposure pathways was ranked differently in the studies and may be attributed to various concentrations and speciation of THMs and HAAs present in the water (15,31,22,17,32).…”

Section: Resultsmentioning

confidence: 99%

“…The second approved risk assistant model was the US.EPA approved risk assistant model which adopted by many researchers (14,15,16,17). Carcinogenic risks resulted from the exposure to both THMs and HAAs concentrations were calculated using the US.EPA method.…”

Section: Risk Evaluation Methodologymentioning

confidence: 99%

“…The following relationships were used to calculate the cancer risks for THMs and HAAs through ingestion, dermal contact, and inhalation following previous studies (20,15,21,22,17,23). THMs or HAAs carcinogenic risk of oral route = LADD oral × CSF oral THMs carcinogenic risk of dermal absorption = LADD dermal × CSF oral THMs carcinogenic risk of inhalation = LADD inhalation ×CSF inhalation Where LADD is the Lifetime daily dose (mg/kg/day) and CSF is cancer slope factor (mg/kg/day) of THMs and HAAs species.…”

Section: Risk Evaluation Methodologymentioning

confidence: 99%

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Evaluation of Human Health Risks Associated with Exposure to Disinfection by-Products (Dbps) in Drinking Water of Wassit Province Southeast Iraq

Journal¹

2018

Baghdad Sci.J

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The toxicological risks and lifetime cancer risks associated with exposure to disinfection by-products (DBPs) including Halloacetic acids (HAAs) and trihalomethanes (THMs) compounds by drinking water in several districts in Wassit Province were estimated. The seasonal variation of HAAs and THMs compounds in drinking water have indicated that the mean values for total HAAs (THAAs) and total THMs (TTHMs) ranged from 43.2 to 72.4 mg/l and from 40 to 115.5 mg/l, respectively. The World health organization index for additive toxicity approach was non-compliant with the WHO guideline value in summer and autumn seasons and this means that THMs concentration has adverse toxic health effects. The multi-pathway of lifetime human health risk of cancer credited to THMs and HAAs in drinking water via three exposure routes for THMs and only one exposure route for HAAs was evaluated and found to be 6.13×10-4 and 1.78×10-4 respectively and these values were higher than the US.EPA range of concern limit of 1×10-6. The risk ratio of THAAs to TTHMs was 3.44. Also, the highest cancer risk was recorded for BDCM followed by DBCM, CF, TCAA, DCAA, and BF.

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Drinking Water Chlorination and Disinfection by-Products: Formation, History, and Regulations

Mazhar,

Madhav,

Ahmed

et al. 2024

Drinking Water Disinfection by-Products

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Cancer risk assessment on trihalomethanes and haloacetic acids in drinking water of China using disability-adjusted life years

Cited by 86 publications

References 35 publications

Disinfection Byproducts in Drinking Water and Evaluation of Potential Health Risks of Long-Term Exposure in Nigeria

Disinfection Byproducts in Drinking Water and Evaluation of Potential Health Risks of Long-Term Exposure in Nigeria

Evaluation of Human Health Risks Associated with Exposure to Disinfection by-Products (Dbps) in Drinking Water of Wassit Province Southeast Iraq

Drinking Water Chlorination and Disinfection by-Products: Formation, History, and Regulations

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