Cancer Risk and Life Expectancy of Children with Ulcerative Colitis

Devroede, Ghislain; Taylor, William F.; Sauer, William G.; Jackman, Raymond J.; Stickler, Gunnar B.

doi:10.1056/nejm197107012850103

Cited by 442 publications

(129 citation statements)

References 22 publications

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“…UC carcinomas also develop at an earlier age when compared to sporadic carcinomas probably because of the early age of onset of UC in many individuals. Patients with onset of UC in childhood may have had the disease for 20 to 30 years with its associated increased risk of cancer, before the age of 40 (Devroede et al, 1971). Initially the prognosis of UC tumours was thought to be worse than sporadic tumours (van Heerden & Beart, 1980) but later studies controlled for Duke's stage found the survival rates to be the same (Hughes et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

“…A number of clinical differences are also apparent between sporadic colorectal carcinomas and UC related carcinomas. Tumours occur in a younger age group in UC with a mean age of onset of [40][41][42] years, which is much earlier than colorectal cancers without UC (Devroede et al, 1971). These tumours are often multicentric and more evenly distributed throughout the colon compared to non UC tumours, though in UC, development of cancer occurs 10 years later in the left colon than in the transverse and right colon (Greenstein et al, 1979).…”

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confidence: 99%

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c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis

Bell

Kelly²,

Hoyle³

et al. 1991

Br J Cancer

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Summary One hundred and nine samples comprising carcinomas, adenomas, dysplastic, inflamed and normal mucosa from patients with sporadic colon cancer and ulcerative colitis (UC) were analysed for c-Ki-ras mutations. DNA was extracted from archival paraffin-embedded material, amplified using the polymerase chain reaction (PCR) and the PCR products analysed using restriction enzyme digestion. Forty-two per cent (14/33) of the sporadic carcinoma controls contained Ki-ras codon 12 mutations in contrast to 24% (8/33) of ulcerative colitis carcinomas. A significantly higher c-Ki-ras mutation rate was observed in rectal carcinomas (72%) in comparison to colonic carcinomas (28%) in control patients (P<0.04), while the opposite was observed in UC patients. The difference between the incidence of c-Ki-ras mutations in rectal carcinomas in UC (9%) and in sporadic rectal carcinomas (72%) was also significant (P<0.01). This lower prevalence rate and different site distribution of c-Ki-ras mutations in UC carcinomas compared to sporadic carcinomas suggests that specific genetic differences may underlie the causation of carcinomas arising in these situations.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis

Bell

Kelly²,

Hoyle³

et al. 1991

Br J Cancer

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“…A longo prazo, a mais temida complicação é a malignização, com surgimento de câncer de colo. Assim, a cada dez anos, há necessidade de se realizar colonoscopia e biópsias seriadas para detecção precoce de câncer de colo 13 .…”

Section: Quadro Clínicounclassified

Inflammatory bowel diseases

Barbieri¹

2000

J Pediatr (Rio J)

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* Livre-docente em Pediatria, Instituto da Criança do HCFMUSP. ResumoObjetivo: Apresentar uma revisão sobre doenças inflamatórias do intestino em crianças, visando familiarizar o pediatra com estas duas doenças, retooclite ulcerativa inespecífica e Doença de Crohn, pois ambas vem aumentando de freqüência.Métodos: Foram analisados artigos de periódicos específicos em gastroenterologia e referentes às doenças em pauta, acrescidas de informações decorrentes da experiência cristalizada da autora no manejo de pacientes portadores dessas doenças.Resultados: São descritas em separado cada uma das duas doenças. A etiopatogênese persiste obscura. O quadro clínico, o diagnóstico e o tratamento são descritos com detalhes e de modo prático, para possibilitar uma imediata aquisição de conhecimentos pelo pediatra.Conclusão: A doença inflamatória do intestino é uma situação de elevada morbidade, exigindo do médico assistente, além de conhecimentos técnicos, muita compreensão e tranqüilidade emocional para conduzir a evolução da doença de modo a permitir ao pequeno paciente a melhor qualidade de vida possível. J. pediatr. (Rio J.). 2000; 76 (Supl.2):S173-S180: colite, ileite, doença inflamatória, retocolite ulcerativa, doença de Crohn. AbstractObjective: To present a review about inflammatory bowel disease in children so that pediatricians become familiar with two diseases (Ulcerative colitis and Crohn's Disease) which are increasing in incidence.Methods: Articles from specific gastroenterological journals were analyzed. Information was also obtained from the author's extensive professional experience in the area.Results: The two diseases are described. Their etiopathogenesis is still obscure. Clinical presentation, diagnosis and current treatments are discussed with details and practical aspects to enable a quick understanding of the subject by pediatricians.Conclusions: Inflammatory bowel disease is a condition of high morbidity, and the attending pediatrician must have very good technical knowledge about it. He/she must also be very comprehensive and emotionally serene to afford the young patient a better quality of life throughout the complicated evolution of this disease.J. pediatr. (Rio J.). 2000; 76 (Supl.2):S173-S180: ulcerative colitis, colitis, ileitis, Crohn's disease. Doenças inflamatórias intestinaisInflammatory bowel disease Dorina Barbieri* IntroduçãoAs doenças inflamatórias do intestino são doenças crô-nicas, de etiologia desconhecida, mas capazes de desenvolver uma reação inflamatória na mucosa digestiva de natureza imunológica. Elas são representadas por três doenças: a retocolite ulcerativa inespecífica (RCUI), a doença de Crohn (DC) e a colite indeterminada.Na retocolite ulcerativa, apenas o colo é acometido; na doença de Crohn qualquer parte do trato digestivo pode ser acometido. A colite indeterminada é a situação de acometimento do colo por um processo inflamatório de difícil caracterização entre RCUI e DC.São doenças emergentes e crescentes dentro da pediatria, e o médico pediatra deve estar atento. A qu...

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“…For instance, 10 ± 60% of patients with ulcerative colitis, a disease characterized by chronic in®ltration of the colon with leukocytes, eventually develop colon cancer (Devroede et al, 1971;Greenstein et al, 1979). Similarly, chronic in¯ammation of the skin, urinary bladder, gall bladder, stomach, esophagus, bone, etc, is associated with an increased incidence of malignancies in these tissues (Weitzman and Gordon, 1990).…”

Section: Introductionmentioning

confidence: 99%