Cancer risk among patients with condylomata acuminata

Abstract

Condylomata acuminata have been shown to increase the risk of anogenital cancers. However, previous studies have been of limited sample size and/or short follow-up duration, which prevent precise estimates of long-term excess risk, especially for specific cancer sites. We estimated the risk of specific cancers in a large cohort of hospitalized patients with condylomata acuminata, as recorded in the Swedish Inpatient Register between 1965 and 1999. Altogether, 10,971 patients (1,685 men and 9,286 women) were followed through 1999 for a median of 13 years. The standardized incidence ratio (SIR)-the ratio of the observed number of cancers to the number expected on the basis of the incidence in the Swedish population at large-was used as a measure of relative risk. After excluding the first-year of follow-up, we observed 43 cases of anogenital cancer in women, and 7 cases in men. Risks were elevated for cancers of the vulva (N 5 13, SIR 5 10.2, 95% confidence interval (CI) 5 5.4-17.4), vagina (N 5 4, SIR 5 12.0, 95% CI 5 3.3-30.7) and penis (N 5 5, SIR 5 21.9, 95% CI 5 7.1-51.2). There was a moderate excess risk of cervical cancer in situ (N 5 259, SIR 5 1.9, 95% CI 5 1.7-2.1), but not invasive cervical cancer. Excess risks of esophageal, buccal cavity, nonmelanoma skin, lung and bladder cancers, and Hodgkin and non-Hodgkin lymphoma, were also observed in both men and women. In conclusion, condylomata acuminata are strongly associated with increased risk of cancers of the vulva, vagina, penis and anus, as well as some nonanogenital malignancies, but not invasive cervical cancer. ' 2006 Wiley-Liss, Inc.

Risk Factors for Cervical Human Papillomavirus Infection and High-Grade Intraepithelial Lesion in Women Aged 20 to 31 Years in Germany

“…33Y35 This is suggested to be the main reason for an increased (pre-) cancer risk among those women. 36,37 Blomberg et al 38 found that individuals with genital warts not only have an elevated risk of anogenital cancer but also for head-and-neck cancer. The authors suggest that patients with genital warts differ from the general population, with risk factors other than HPV putting them at increased risk for several cancer types.…”

Investigação da LMP1 do EBV e a coinfeçcão do HPV em lesões genitais de pacientes infectados ou não pelo HIV

“…Sobre a infecção na região genital existem poucos estudos. Torna-se relevante identificar a infecção epitelial genital pelo EBV, bem como a possível coinfecção com o HPV, principal agente associado ao desenvolvimento de lesões intraepiteliais e carcinomas escamosos genitais (17,19) . O imunocomprometimento relacionado com o vírus da imunodeficiência humana do tipo 1 (HIV-1) é sabidamente um fator de aumento do risco para a carcinogênese genital, assim, torna-se relevante verificar possíveis diferenças entre os pacientes (13,15) .…”

Prevalence of Human Papillomavirus in Anal and Oral Sites Among Patients with Genital Warts

“…Self-inoculation has been suggested in HPV-positive Bowen's disease of the digital nail bed (15). Interestingly, it has been reported in epidemiological studies from Sweden and Denmark, that the incidence of anal and oral cavity cancers is approximately 10-and 4-fold higher, respectively, in patients with a hospital record of genital warts (16,17). Additionally, an American study showed that MSM who have had anal warts had a 50-fold higher risk of developing anal cancer (18).…”