Cancer‐related fatigue measures in palliative care: A psychometric systematic review

Montagut-Martínez, Pedro; Pérez-Cruzado, César; Sánchez, Daniel Gutiérrez

doi:10.1111/ecc.13642

Cited by 2 publications

(1 citation statement)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Longitudinal studies are needed that assess for associations between changes in CRF and changes in gene expression and pathway perturbations. Given the heterogeneity of CRF instruments, 52,53 and that no gold standard exists for the assessment of CRF, 54 future studies need to evaluate whether the same perturbed pathways are identified using a variety of instruments. The strict FDR cutoff excluded some pathways on either F I G U R E 1 A knowledge network generated from connections among the common and distinct perturbed inflammation-related KEGG signaling pathways associated with morning and evening cancer-related fatigue.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Perturbations in common and distinct inflammatory pathways associated with morning and evening fatigue in outpatients receiving chemotherapy

et al. 2022

View full text Add to dashboard Cite

Background Moderate to severe fatigue occurs in up to 94% of patients with cancer. Recent evidence suggests that morning and evening fatigue are distinct dimensions of physical fatigue. The purposes of this study were to evaluate the transcriptome for common and distinct perturbed inflammatory pathways in patients receiving chemotherapy who reported low versus high levels of morning or low versus high levels of evening cancer‐related fatigue. Methods Patients completed questionnaires during the week prior to their chemotherapy treatment. Severity of morning and evening fatigue was evaluated using the Lee Fatigue Scale. Gene expression and pathway impact analyses (PIA) were performed in two independent samples using RNA‐sequencing ( n = 357) and microarray ( n = 360). Patterns of interactions between and among these perturbed pathways were evaluated using a knowledge network (KN). Results Across the PIA, nine perturbed pathways (FDR < 0.025) were common to both morning and evening fatigue, six were distinct for morning fatigue, and four were distinct for evening fatigue. KN (19 nodes, 39 edges) identified the phosphatidylinositol 3‐kinase (PI3K)‐Akt pathway node (perturbed in evening fatigue) with the highest betweenness (0.255) and closeness (0.255) centrality indices. The next highest betweenness centrality indices were seen in pathways perturbed in evening fatigue (i.e., nuclear factor kappa B: 0.200, natural killer cell‐mediated cytotoxicity: 0.178, mitogen‐activated protein kinase: 0.175). Conclusions This study describes perturbations in common and distinct inflammatory pathways associated with morning and/or evening fatigue. PI3K‐Akt was identified as a bottleneck pathway. The analysis identified potential targets for therapeutic interventions for this common and devastating clinical problem.

show abstract

Section: Strengths and Limitationsmentioning

confidence: 99%