Cancer-Related Fatigue

Berger, Ann M.; Abernethy, Amy Pickar; Atkinson, Ashley; Barsevick, Andrea; Breitbart, William; Cella, David; Cimprich, Bernadine; Cleeland, Charles S.; Eisenberger, Mario A.; Escalante, Carmen P.; Jacobsen, Paul B.; Kaldor, Phyllis; Ligibel, Jennifer A.; Murphy, Barbara A.; O’Connor, Tracey; Pirl, William F.; Rodler, Eve T.; Rugo, Hope S.; Thomas, James; Wagner, Lynne I.

doi:10.6004/jnccn.2010.0067

Cited by 215 publications

(149 citation statements)

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“…Cancer-related fatigue, one of the most prevalent symptoms in cancer (1,2), is defined as "a distressing persistent, subjective sense of tiredness or exhaustion related to cancer or its treatment that is not proportional to recent activity and interferes with usual functioning" (3). Between 30% to 95% of patients undergoing chemotherapy are affected, depending on cancer type and method to define fatigue (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Low Recent Protein Intake Predicts Cancer-Related Fatigue and Increased Mortality in Patients with Advanced Tumor Disease Undergoing Chemotherapy

Stobäus

Müller

Küpferling

et al. 2015

Nutrition and Cancer

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Cancer patients, in general, suffer from anorexia hence diminished nutritional intake. In a prospective observational study, we investigated the impact of recent energy and protein intake on cancer-related fatigue and 6-month mortality in patients undergoing chemotherapy. Recent protein and energy intake was assessed by 24-h recall in 285 patients. Cancer-related fatigue was determined by Brief Fatigue Inventory, and fat free mass index (FFMI) was assessed with bioelectrical impedance analysis. Symptoms with the validated German version of European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (30 questions) and 6-month mortality was documented. Risk factors of cancer-related fatigue and predictors of mortality were investigated with logistic regression analysis and stepwise Cox regression analysis, respectively. Low protein intake (<1 g/kg body weight) was found in 66% of patients, who were characterized by higher age, weight, and body mass index. Recent protein intake emerged as the strongest contributor to cancer-related fatigue followed by nausea/vomiting, insomnia, and age. Reduced protein intake, male sex, number of comorbidities, and FFMI were identified as significant predictors for increased 6-month mortality. In conclusion, a low recent protein intake assessed by 24-h recall is associated with a more than twofold higher risk of cancer-related fatigue and 6-month mortality. Every effort should be taken to assess and guarantee proper nutritional intake in patients undergoing chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Low Recent Protein Intake Predicts Cancer-Related Fatigue and Increased Mortality in Patients with Advanced Tumor Disease Undergoing Chemotherapy

Stobäus

Müller

Küpferling

et al. 2015

Nutrition and Cancer

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“…Oncology patients often suffer from psychological and psychosomatic symptoms, resignation and dejection, or a fear of progression [21,22]. Access to psycho-oncological counselling and treatment must be ensured in certified organ cancer centres, and the process has to be evidentially validated [23].…”

Section: From the Point Of View Of The Certified Breast Cancer Centresmentioning

confidence: 99%

Relevance of Health Economics in Breast Cancer Treatment - the View of Certified Breast Centres and Their Patients

Lux¹,

Hildebrandt²,

Beyer-Finkler³

et al. 2013

Breast Care

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Breast cancer centres - certified in accordance with the criteria of the German Cancer Association and the German Mastology Association - are established throughout Germany. Although the setting up of centres and the subsequent need for certification are associated with a marked increase in costs, initial data show positive effects on quality. Certified centres are cost-effective from the point of view of health economics - they lead to improved quality in processes and results without creating any increase in costs for the funding bodies. However, the organization of the necessary structures, with interdisciplinary treatment, documentation and quality-assurance measures, requires considerable resources. Increasing consolidation of inpatient services is also involved, while shortening of the patients' hospitalization periods is leading to reduced remuneration from the funding bodies. The current cost deficits, which have resulted from the increased resources required, need to be recouped through additional charges. It will only be possible to maintain the high quality achieved if additional charges become available to cover the centres' added costs. Good data are increasingly becoming available as a basis for negotiations on charges - e.g., with regard to the quality of results and the National Cancer Plan - as well as clear support from patients.

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“…In addition to other adverse effects, these agents have been commonly reported to cause fatigue [1][2][3][4]. Fatigue is a subjective sense of tiredness related to cancer treatment, not in proportion to recent activity, which interferes with physical, emotional, and/or cognitive functioning [5,6]. Indeed, fatigue related to the underlying cancer is a common persistent and distressing symptom [7].…”

Section: Introductionmentioning

confidence: 98%

Fatigue with vascular endothelial growth factor receptor tyrosine kinase inhibitors and mammalian target of rapamycin inhibitors in patients with renal cell carcinoma (RCC) and other malignancies: A meta-analysis of randomized clinical trials

Ghatalia

Nguyen

et al. 2015

Critical Reviews in Oncology/Hematology

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Cancer-Related Fatigue

Cited by 215 publications

References 0 publications

Low Recent Protein Intake Predicts Cancer-Related Fatigue and Increased Mortality in Patients with Advanced Tumor Disease Undergoing Chemotherapy

Low Recent Protein Intake Predicts Cancer-Related Fatigue and Increased Mortality in Patients with Advanced Tumor Disease Undergoing Chemotherapy

Relevance of Health Economics in Breast Cancer Treatment - the View of Certified Breast Centres and Their Patients

Fatigue with vascular endothelial growth factor receptor tyrosine kinase inhibitors and mammalian target of rapamycin inhibitors in patients with renal cell carcinoma (RCC) and other malignancies: A meta-analysis of randomized clinical trials

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