Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment

Fabi, Alessandra; Bhargava, Ravi; Fatigoni, Sonia; Guglielmo, Mauro; Horneber, Markus; Roila, Fausto; Weis, Joachim; Jordan, Karin; Ripamonti, Carla

doi:10.1016/j.annonc.2020.02.016

Cited by 259 publications

(255 citation statements)

References 96 publications

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“…For example, fatigue, highlighted by participants as one of the most debilitating issues, may contribute to the need to reduce chemotherapy dose-intensity. However, fatigues is often multifactorial and addressing factors such as anaemia, vitamin deficiencies, thyroid dysfunction, physical exercise, nutrition and social support could reduce fatigue and allow patients to maintain treatment intensity, meeting both patient needs and preferences [22].…”

Section: Discussionmentioning

confidence: 99%

Exploring Older Women’s Attitudes to and Experience of Treatment for Advanced Ovarian Cancer: A Qualitative Phenomenological Study

Dumas

Lidington

Appadu

et al. 2021

Cancers

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Older women with ovarian cancer more often receive less intensive treatment and early discontinuation compared to younger women. There is little understanding of older women’s treatment experience and whether this contributes to declining intensive treatment. We aimed to explore the lived experience of older patients with advanced ovarian cancer undergoing chemotherapy, their treatment preferences and treatment burden. We conducted a phenomenological qualitative study with 15 women who had completed at least three cycles of first-line chemotherapy for advanced epithelial ovarian cancer, aged 65 years or older at the first cycle, at one tertiary cancer centre. We conducted interviews and focus groups and analysed the transcripts using inductive thematic analysis. Women reported a strong preference for active treatment despite treatment burden and toxicities. Participants undertook treatment to lengthen their lives for themselves and their families. Participants did not see age as a barrier to treatment. Patients expressed determination not to let cancer interfere with daily life. Women felt overwhelmed with information and struggled with daily tasks due to fatigue. Logistical issues, such as transportation and ineffective communication between healthcare providers, caused substantial distress. Despite these logistical burdens and toxicities, participants were positive about their care experience and desire for anticancer treatment. Older women may benefit from additional support to facilitate effective communication during the early stages of treatment.

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Section: Discussionmentioning

confidence: 99%

Exploring Older Women’s Attitudes to and Experience of Treatment for Advanced Ovarian Cancer: A Qualitative Phenomenological Study

Dumas

Lidington

Appadu

et al. 2021

Cancers

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“…Efforts to sustainably implement evidenced-based CRF management strategies into routine clinical care are urgently needed, owing to the high incidence, prevalence and burden of CRF in cancer survivors severely impacting health-related quality of life [1]. Despite established CRF management strategies [1,16], sustainable models of care connecting cancer survivors to effective CRF interventions have yet to be satisfactorily investigated [42]. Indeed, our systematic scoping review was able to identify only six studies evaluating the implementation of interventions designed for individuals experiencing CRF, all of which had limited external validity and lacked methodological rigor (e.g.…”

Section: Discussionmentioning

confidence: 99%

Bridging the Research to Practice Gap: A Systematic Scoping Review of Implementation of Interventions for Cancer-Related Fatigue Management

Agbejule

Hart

Ekberg

et al. 2020

Preprint

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Background. Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in people with cancer. Whilst efficacy of interventions for CRF have been extensively investigated, less has been done to ensure successful translation into routine clinical practice. The aim of this systematic scoping review was to synthesise knowledge surrounding the implementation of CRF interventions, summarise the processes and outcomes of implementation strategies used, and identify opportunities for further research.Methods. PubMed, Cochrane CENTRAL, EMBASE and CINAHL databases were searched through to December 2020. The Cochrane Effective Practice and Organisation of Care (EPOC) Group taxonomy and the RE-AIM Framework were used to guide the evaluation of implementation strategies and outcomes, respectively. Results. Six studies were included. Three used implementation frameworks (PARIHS, KTA, Cullens & Adams’ Implementation Guide) to guide implementation. Overall, the implementation strategies used across all studies were reported to have directly resulted in immediate changes at the clinician level (e.g., increased clinician behaviours, self-efficacy, attitudes, knowledge of CRF management). No clear relationship was found between the use of implementation models and the number or type of implementation strategies used. For outcomes, Effectiveness and Implementation were the most highly reported RE-AIM measures followed by Reach then Maintenance. Adoption was the least reported.Conclusions. Despite the high prevalence of CRF and evidence-based interventions for managing CRF, there is limited evidence informing the sustainable implementation of these interventions. There was an absence of external indicator reporting (e.g., start-up and ongoing intervention costs) in included studies, limiting the transability of study findings. Further, factors such as lack of clinician time, insufficient program funding, and unsustainable maintenance costs, were highlighted as key implementation barriers of CRF programs. This scoping systematic review emphasises the lack of quality CRF implementation studies presently available in the literature leading to a disconnect between effective CRF interventions, routine clinical care, and cancer survivors at present. Further, this review also highlights the need for robust study designs guided by established frameworks to methodically design and evaluate the implementation of CRF management interventions in the future.

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“…Cancer-related figure (CRF) is the most prevalent symptom experienced during the cancer trajectory (incidence of 40% at diagnosis and 80–90% during chemo- and/or radiotherapy) ( 71 ). CRF is defined as a distressing, persistent, subjective sense of physical, emotional and/or cognitive tiredness or exhaustion related to cancer or cancer treatment ( 72 ).…”

Section: Delivering Cancer Care To Individuals With Asd: Potential Obmentioning

confidence: 99%

“…CRF is defined as a distressing, persistent, subjective sense of physical, emotional and/or cognitive tiredness or exhaustion related to cancer or cancer treatment ( 72 ). No studies or reviews published addressing how to measure and manage CRF in the ASD population, which constitutes a major issue as it significantly impacts quality of life and other treatment outcomes ( 71 , 72 ). Its perception and expression are most likely altered in children and adults with ASD.…”

Section: Delivering Cancer Care To Individuals With Asd: Potential Obmentioning

confidence: 99%

Cancer Care of Children, Adolescents and Adults With Autism Spectrum Disorders: Key Information and Strategies for Oncology Teams

et al. 2021

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Delivering optimal cancer care to children, adolescents and adults with ASD has recently become a healthcare priority and represents a major challenge for all providers involved. In this review, and after consideration of the available evidence, we concisely deliver key information on this heterogenous group of neurodevelopmental disorders, as well as recommendations and concrete tools for the enhanced oncological care of this vulnerable population of patients.

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Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment

Cited by 259 publications

References 96 publications

Exploring Older Women’s Attitudes to and Experience of Treatment for Advanced Ovarian Cancer: A Qualitative Phenomenological Study

Exploring Older Women’s Attitudes to and Experience of Treatment for Advanced Ovarian Cancer: A Qualitative Phenomenological Study

Bridging the Research to Practice Gap: A Systematic Scoping Review of Implementation of Interventions for Cancer-Related Fatigue Management

Cancer Care of Children, Adolescents and Adults With Autism Spectrum Disorders: Key Information and Strategies for Oncology Teams

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