Cancer Progress and Priorities: Uterine Cancer

Felix, Ashley S.; Brinton, Louise A.

doi:10.1158/1055-9965.epi-18-0264

Cited by 61 publications

(47 citation statements)

References 119 publications

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“…These trends may not reflect true disease occurrence, because they do not account for hysterectomy prevalence, which is higher in black women and rising, but declining in white women . Increasing rates of uterine corpus cancer are likely because of the rising prevalence of obesity . An estimated 60% of uterine corpus cancers among women of all races are attributable to excess body weight …”

Section: Selected Findingsmentioning

confidence: 99%

“…117 Increasing rates of uterine corpus cancer are likely because of the rising prevalence of obesity. 118 An estimated 60% of uterine corpus cancers among women of all races are attributable to excess body weight. 119 From 2007 to 2016, the death rate for cancer of the uterine corpus increased by 2.2% per year in NH black women and by 1.7% per year in white women, mirroring the trends for incidence.…”

Section: Uterine Corpusmentioning

confidence: 99%

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Cancer statistics for African Americans, 2019

DeSantis

Miller

Sauer

et al. 2019

CA A Cancer J Clinicians

618

555

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In the United States, African American/black individuals bear a disproportionate share of the cancer burden, having the highest death rate and the lowest survival rate of any racial or ethnic group for most cancers. To monitor progress in reducing these inequalities, every 3 years the American Cancer Society provides the estimated number of new cancer cases and deaths for blacks in the United States and the most recent data on cancer incidence, mortality, survival, screening, and risk factors using data from the National Cancer Institute, the North American Association of Central Cancer Registries, and the National Center for Health Statistics. In 2019, approximately 202,260 new cases of cancer and 73,030 cancer deaths are expected to occur among blacks in the United States. During 2006 through 2015, the overall cancer incidence rate decreased faster in black men than in white men (2.4% vs 1.7% per year), largely due to the more rapid decline in lung cancer. In contrast, the overall cancer incidence rate was stable in black women (compared with a slight increase in white women), reflecting increasing rates for cancers of the breast, uterine corpus, and pancreas juxtaposed with declining trends for cancers of the lung and colorectum. Overall cancer death rates declined faster in blacks than whites among both males (2.6% vs 1.6% per year) and females (1.5% vs 1.3% per year), largely driven by greater declines for cancers of the lung, colorectum, and prostate. Consequently, the excess risk of overall cancer death in blacks compared with whites dropped from 47% in 1990 to 19% in 2016 in men and from 19% in 1990 to 13% in 2016 in women. Moreover, the black‐white cancer disparity has been nearly eliminated in men <50 years and women ≥70 years. Twenty‐five years of continuous declines in the cancer death rate among black individuals translates to more than 462,000 fewer cancer deaths. Continued progress in reducing disparities will require expanding access to high‐quality prevention, early detection, and treatment for all Americans.

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Section: Selected Findingsmentioning

confidence: 99%

Section: Uterine Corpusmentioning

confidence: 99%

Cancer statistics for African Americans, 2019

DeSantis

Miller

Sauer

et al. 2019

CA A Cancer J Clinicians

618

555

View full text Add to dashboard Cite

show abstract

“…Uterine carcinomas with nonendometrioid histology (eg, serous and clear cell carcinomas) are more aggressive and are suggested to be less hormone dependent, with worse outcomes and survival. 6 , 7 Sarcomas generally arise in the myometrium, are less common, and have not been well studied.…”

Section: Introductionmentioning

confidence: 99%

Hysterectomy-Corrected Uterine Corpus Cancer Incidence Trends and Differences in Relative Survival Reveal Racial Disparities and Rising Rates of Nonendometrioid Cancers

Clarke

Devesa

Harvey

et al. 2019

JCO

207

192

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PURPOSE Uterine corpus cancer incidence rates have been projected to increase, a prediction often attributed to the obesity epidemic. However, correct estimation of these rates requires accounting for hysterectomy prevalence, which varies by race, ethnicity, and region. Here, we evaluated recent trends in hysterectomy-corrected rates by race and ethnicity and histologic subtype and estimated differences in relative survival by race and ethnicity, subtype, and stage. METHODS We estimated hysterectomy prevalence from the Behavioral Risk Factor Surveillance System. Hysterectomy-corrected age-standardized uterine corpus cancer incidence rates from 2000 to 2015 were calculated from the SEER 18 registries. Incidence rates and trends were estimated separately by race and ethnicity, region, and histologic subtype. Five-year relative survival rates were estimated by race and ethnicity, histologic subtype, and stage. RESULTS Hysterectomy-corrected incidence rates of uterine corpus cancer were similar among non-Hispanic whites and blacks and lower among Hispanics and Asians/Pacific Islanders. Endometrioid carcinoma rates were highest in non-Hispanic whites, whereas nonendometrioid carcinoma and sarcoma rates were highest in non-Hispanic blacks. Hysterectomy-corrected uterine corpus cancer incidence increased among non-Hispanic whites from 2003 to 2015 and among non-Hispanic blacks, Hispanics, and Asians/Pacific Islanders from 2000 to 2015. Overall incidence rates among non-Hispanic blacks surpassed those of non-Hispanic whites in 2007. Endometrioid carcinoma rates rose among non-Hispanic blacks, Hispanics, and Asians/Pacific Islanders but were stable among non-Hispanic whites; however, nonendometrioid carcinoma rates rose significantly among all women. Non-Hispanic blacks had the lowest survival rates, irrespective of stage at diagnosis or histologic subtype. CONCLUSION Among all women, rates of nonendometrioid subtypes have been rising rapidly. Our analysis shows profound racial differences and disparities indicated by higher rates of nonendometrioid subtypes and poorer survival among non-Hispanic black women.

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“…Endometrial cancer (EC) is a leading gynecological malignancy in the developed world and its incidence is rapidly increasing [ 1 , 2 ]. Classification according to endocrine and metabolic disturbances divides endometrial cancer into two types.…”

Section: Introductionmentioning

confidence: 99%

Tie-2, G-CSF, and Leptin as Promising Diagnostic Biomarkers for Endometrial Cancer: A Pilot Study

Roškar

Klančič

Knific

et al. 2021

JCM

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Preoperative determination of the extent of endometrial cancer (EC) would avoid the complications associated with radical surgery. Screening of patients’ plasma biomarkers might enable a more precise diagnosis of EC and a tailored treatment approach. This prospective case-control monocentric pilot study included 76 postmenopausal women (38 endometrioid EC patients and 38 control patients with benign gynecological conditions), and 37 angiogenic factors (AFs) were investigated as potential biomarkers for EC. AF concentrations in preoperative plasma samples were measured using Luminex xMAP™ multiplexing technology. The plasma levels of sTie-2 and G-CSF were significantly lower in EC compared to control patients, whereas the plasma levels of leptin were significantly higher in EC patients. Neuropilin-1 plasma levels were significantly higher in patients with type 2 EC (grade 3) compared to patients with lower grade cancer or controls. Follistatin levels were significantly higher in patients with lymphovascular invasion, and IL-8 plasma levels were significantly higher in patients with metastases. If validated, the plasma concentrations of the indicated AFs could represent an important additional diagnostic tool for the early detection and characterization of EC. This could guide the decision-making on the extent of surgery. Further studies with larger patient numbers are currently ongoing.

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Cancer Progress and Priorities: Uterine Cancer

Cited by 61 publications

References 119 publications

Cancer statistics for African Americans, 2019

Cancer statistics for African Americans, 2019

Hysterectomy-Corrected Uterine Corpus Cancer Incidence Trends and Differences in Relative Survival Reveal Racial Disparities and Rising Rates of Nonendometrioid Cancers

Tie-2, G-CSF, and Leptin as Promising Diagnostic Biomarkers for Endometrial Cancer: A Pilot Study

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