Cancer preventive properties of ginger: A brief review

Shukla, Yogeshwer; Singh, Madhulika

doi:10.1016/j.fct.2006.11.002

Cited by 681 publications

(498 citation statements)

References 57 publications

Supporting

Mentioning

439

Contrasting

Unclassified

Order By: Relevance

“…For centuries, it has been used as food flavoring agent as well as for traditional medicinal purposes (Ali et al, 2008). Current trend in research has focused its attention to ginger given its anti-cancer, anti-oxidant, and anti-inflammatory properties (Masuda et al, 2004;Grzanna et al, 2005;Shukla and Singh, 2007;Habib et al, 2008). Recently, our laboratory has demonstrated anti-tumor effects of ginger extracts against colon cancer cell lines through the induction of apoptotic pathway coupled with cell cycle arrest at G 0 /G 1 phase (Abdullah et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells

Hakim¹,

Alias²,

Makpol³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells

Hakim¹,

Alias²,

Makpol³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…It is regarded as a promising chemopreventive dietary agent exhibiting inhibition of cyclooxygenase and lipoxygenase activities (Kiuchi et al, 1982(Kiuchi et al, : 1992Huang et al, 1991), apoptosis induction (Lee et al, 1998;Chauhan, 2002), and anti-tumorigenic effects (Park et al, 1998;Surh et al, 1999). The pungent vallinoids of ginger, [6]-gingerol and [6]-paradol, exhibit antiproliferation activity in liver, pancreatic, prostate, gastric, and leukemia cancer cells (Lee et al, 1998;Chen et al, 2007;Shukla and Singh, 2007). Furthermore, [6]-shogaol has also been shown to exhibit anticancer activities against breast cancer through the inhibition of cell invasion reduction of matrix metalloproteinase-9 expression (via blockade of nuclear factor activation) (Ling et al, 2010), anti-proliferation activity (through disruption of microtubule network of non-small lung epithelium cancer) (Choudhury et al, 2010), and antiinvasion on human hepatocellular cell (Weng et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Plengsuriyakarn¹,

Viyanant²,

Eursitthichai³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Cholangiocarcinoma (CCA) is an uncommon adenocarcinoma which arises from the epithelial cells of the bile ducts. The aim of the study was to investigate the cytotoxicity, toxicity, and anticancer activity of a crude ethanolic extract of ginger (Zingiber officinale Roscoe) against CCA. Cytotoxic activity against a CCA cell line (CL-6) was assessed by calcein-AM and Hoechst 33342 assays and anti-oxidant activity was evaluated using the DPPH assay. Investigation of apoptotic activity was performed by DNA fragmentation assay and induction of genes that may be involved in the resistance of CCA to anticancer drugs (MDR1, MRP1, MRP2, and MRP3) was examined by real-time PCR. To investigate anti-CCA activity in vivo, a total of 80 OV and nitrosamine (OV/ DMN)-induced CCA hamsters were fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days. Control groups consisting of 10 hamsters for each group were fed with 5-fluorouracil (positive control) or distilled water (untreated control). Median IC 50 (concentration that inhibits cell growth by 50%) values for cytotoxicity and anti-oxidant activities of the crude ethanolic extract of ginger were 10.95, 53.15, and 27.86 μg/ml, respectively. More than ten DNA fragments were visualized and up to 7-9 fold up-regulation of MDR1 and MRP3 genes was observed following exposure to the ethanolic extract of ginger. Acute and subacute toxicity tests indicated absence of any significant toxicity at the maximum dose of 5,000 mg/kg body weight given by intragastric gavage. The survival time and survival rate of the CCA-bearing hamsters were significantly prolonged compared to the control group (median of 54 vs 17 weeks). Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity. Moreover, MDR1 and MRP3 may be involved in conferring resistance of CCA to the ginger extract.

show abstract

“…In order to determine the 5S or 5R configuration of 1 -3, we tried to grow single crystals but the structure determination failed due to the small size of the needle-shaped crystals obtained. We also hoped to compare their optical rotations with those of the known analogous compounds, [6]-gingesulfonic acid and [4]-gingesulfonic acid, to determine the absolute stereochemistry of 1 -3, but the stereochemistry at C-5 has not been reported in the literature [11]. Trying to grow single crystals suitable for X-ray structure determinations of compounds 1 -3 as well as of 10 and 11 is clearly necessary in further work.…”

Section: Resultsmentioning

confidence: 99%