Cancer‐preventive activities of secondary metabolites from leaves of the bilberry <i>Vaccinium smallii</i> A. Gray

Mechikova, G. Ya.; Kuzmich, Alexandra S.; Ponomarenko, L. P.; Kalinovsky, A. I.; Степанова, Т. А.; Fedorov, Sergey N.; Stonik, Valentin A.

doi:10.1002/ptr.3282

Cited by 12 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, bilberry leaves have been explored for their protective activities against cancer. Flavonoids, caffeic acid, and chlorogenic acid were isolated from Sakhalin bilberry Vaccinium smallii leaves and were studied as cancer-preventive agents; they inhibited epidermal growth factor (EGF)-induced neoplastic transformation of mouse cells, without exerting any toxic effects [ 33 ].…”

Section: Bilberry ( Vaccinium Myrtillus ) Leavementioning

confidence: 99%

Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value

2016

View full text Add to dashboard Cite

Berry fruits are recognized, worldwide, as “superfoods” due to the high content of bioactive natural products and the health benefits deriving from their consumption. Berry leaves are byproducts of berry cultivation; their traditional therapeutic use against several diseases, such as the common cold, inflammation, diabetes, and ocular dysfunction, has been almost forgotten nowadays. Nevertheless, the scientific interest regarding the leaf composition and beneficial properties grows, documenting that berry leaves may be considered an alternative source of bioactives. The main bioactive compounds in berry leaves are similar as in berry fruits, i.e., phenolic acids and esters, flavonols, anthocyanins, and procyanidins. The leaves are one of the richest sources of chlorogenic acid. In various studies, these secondary metabolites have demonstrated antioxidant, anti-inflammatory, cardioprotective, and neuroprotective properties. This review focuses on the phytochemical composition of the leaves of the commonest berry species, i.e., blackcurrant, blackberry, raspberry, bilberry, blueberry, cranberry, and lingonberry leaves, and presents their traditional medicinal uses and their biological activities in vitro and in vivo.

show abstract

Section: Bilberry ( Vaccinium Myrtillus ) Leavementioning

confidence: 99%

Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value

2016

View full text Add to dashboard Cite

show abstract

“…Basic flavonoid structure. V. bracteatum (leaves) [73][74][75] V. uliginosum (fruit) [66] V. vitis-idaea (fruit) [22] V. intermedium (fruit) [22,48] V. meridionale Swartz (fruit) [47] 47 Quercetin V. angustifolium (fruit) [103,104] V. corymbosum (leaves) [18,46,95] V. koreanum (leaves) [54] V. calycinum (leaves) [53] V. myrtillus (fruit & leaves) [21,22,46] V. reticulatum (leaves) [53] V. smallii (leaves) [72] [49]…”

Section: Flavone Flavonol and Their Glycosidesmentioning

confidence: 99%

“…oxycoccos (fruit) [107] V. quadripetalis (leaves) [108] V. angustifolium (fruit) [103,104] V. corymbosum (leaves) [37] V. darrowii (fruit) [109] V. calycinum (leaves) [53] V. myrtillus (fruit & leaves) [22] V. reticulatum (leaves) [53] V. angustifolium (fruit) [103,104] V. virgatum = V. ashei (fruit) [63] V. corymbosum (leaves) [37,46,95] V. myrtillus (fruit) [21,22,46] V. smallii (leaves) [49] V. bracteatum (leaves) [64] V. vitis-idaea (fruit) [42,70] V. intermedium (fruit) [48] 60 Quertine-3-O-galactoside V. macrocarpon (fruit) [4,69] V. smallii (leaves) [49,72] V. bracteatum (leaves) [64] V. vitis-idaea (fruit) [59,70] V. myrtillus (fruit & leaves) [21,22,46] 61…”

Section: Flavone Flavonol and Their Glycosidesmentioning

confidence: 99%

Anthocyanins and Flavonoids of Vaccinium L.

Su¹

2012

TOPHARMCJ

View full text Add to dashboard Cite

Vaccinium L., comprising approximately 450 species primarily in the Northern Hemisphere, is a genus of shrubs or lianas in the family Ericaceae. The berries of many species are harvested for household consumption and commercial sale. The genus produces a wide range of compounds such as anthocyanins, flavonoids, chromones, coumarins, lignans, benzoic acids, iridoids, sterols, and triterpenoids, but is best known for the production of anthocyanins and flavonoids. Extracts and isolates of anthocyanins and flavonoids from Vaccinium fruits or leaves showed antioxidative, anti-inflammatory, antitumor, antiviral, vasoprotective, and antifungal activities. To data, more than 116 anthocyanins and flavonoids compounds have been isolated and identified primarily from the fruits or leaves of Vaccinium. This article reviews phytochemistry and pharmaceutical properties of these compounds.

show abstract

“…However, despite the fact that among dietary sources, Ericaceae berries are particularly abundant in phenolic antioxidants, they accumulate significantly lower levels of total phenolics (usually not more than 15 mg/g gallic acid equivalents, GAE, of dry weight, DW) than those observed in the leaves (usually not less than 40 mg/g GAE DW) [7,8]. Because of this effect and due to the seasonal availability of fresh berries, the leaves of some Ericaceae species have recently been strongly recommended as cost-effective, alternative sources of phenolic antioxidants with great potential for the prevention of chronic diseases [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Profile, Antioxidant and Anti-Inflammatory Activity of Eastern Teaberry (Gaultheria procumbens L.) Leaf Extracts

et al. 2014

View full text Add to dashboard Cite

Dry leaf extracts of eastern teaberry (Gaultheria procumbens L.) were evaluated as a source of bioactive phytocompounds through systematic activity testing and phytochemical profiling. The antioxidant efficiency was tested using five complementary in vitro models (DPPH; FRAP; linoleic acid (LA) peroxidation assay; O2•− and H2O2 scavenging tests) in parallel with standard antioxidants. The 75% methanol extract and its diethyl ether, ethyl acetate (EAF), n-butanol and water fractions exhibited the dose-dependent responses in all assays, with the highest capacities found for EAF (DPPH EC50 = 2.9 μg/mL; FRAP = 12.8 mmol Fe 2+ /g; IC50 for LA-peroxidation = 123.9 μg/mL; O2•− SC50 = 3.9 μg/mL; H2O2 SC50 = 7.2 μg/mL). The EAF had also the highest anti-inflammatory activity in the inhibition tests of lipoxygenase and hyaluronidase (60.14% and 21.83% effects, respectively, at the concentration of 100 μg/mL). Activity parameters of the extracts correlated strongly with the levels of total phenolics (72.4-270.7 mg GAE/g), procyanidins, and phenolic acids, whereas for flavonoids only moderate effects were and HPLC-PDA studies led to the identification of 35 polyphenols with a procyanidin A-type trimer, quercetin 3-O-glucuronide, isomers of caffeoylquinic acids, and (-)-epicatechin being the dominant components. Significant activity levels, high phenolic contents and high extraction yields (39.4%-42.5% DW for defatted and crude methanol extracts, respectively) indicate the value of eastern teaberry leaves as bioactive products.

show abstract

Cancer‐preventive activities of secondary metabolites from leaves of the bilberry Vaccinium smallii A. Gray

Cited by 12 publications

References 5 publications

Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value

Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value

Anthocyanins and Flavonoids of Vaccinium L.

Polyphenolic Profile, Antioxidant and Anti-Inflammatory Activity of Eastern Teaberry (Gaultheria procumbens L.) Leaf Extracts

Contact Info

Product

Resources

About