Cancer prevalence in Israeli men and women with schizophrenia

Agay, Nirit; Flaks‐Manov, Natalie; Nitzan, Uri; Hoshen, Moshe; Levkovitz, Y.; Munitz, Hanan

doi:10.1016/j.psychres.2017.07.082

Cited by 7 publications

(7 citation statements)

References 33 publications

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“…Similar to the pooled analyses (Li et al, 2018) and an Israeli study (Agay et al, 2017), we found a significantly lower risk of prostate cancer in men and a significantly higher risk of lung cancer in women with schizophrenia. In line with the findings from two meta-analyses of observational studies that focused on the association between schizophrenia and female breast cancer (Xiping et al, 2018;Zhuo and Triplett, 2018), we found a higher incidence of breast cancer in women with schizophrenia.…”

Section: Comparison With Previous Studiessupporting

confidence: 86%

The overall and sex- and age-group specific incidence rates of cancer in people with schizophrenia: a population-based cohort study

Pettersson

Gissler

Hällgren

et al. 2020

Epidemiol Psychiatr Sci

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Aims Decades of research show that people with schizophrenia have an increased risk of death from cancer; however, the relationship between schizophrenia and cancer incidence remains less clear. This population-based study investigates the incidence of seven common types of cancer among people with a hospital diagnosis of schizophrenia and accounting for the effects of age, sex and calendar time. Methods This population-based study used 1990–2013 data from three nationwide Swedish registries to calculate the incidence (in total, by age group and by sex) of any cancer and of lung, oesophageal, pancreatic, stomach, colon, (in men) prostate and (in women) breast cancer in 111 306 people with a hospital diagnosis of schizophrenia. The incidence in people with diagnosed schizophrenia was compared with the incidence in the general population. Risk estimates accounted for the effects of calendar time. Results In 1 424 829 person-years of follow-up, schizophrenia did not confer an overall higher cancer risk (IRR 1.02, 95% CI 0.91–1.13) but was associated with a higher risk for female breast (IRR 1.19, 95% CI 1.12–1.26), lung (IRR 1.42, 95% CI 1.28–1.58), oesophageal (IRR 1.25, 95% CI 1.07–1.46) and pancreatic (IRR 1.10, 95% CI 1.01–1.21) and a lower risk of prostate (IRR 0.66, 95% CI 0.55–0.79) cancer. Some age- and sex-specific differences in risk were observed. Conclusions People with schizophrenia do not have a higher overall incidence of cancer than people in the general population. However, there are significant differences in the risk of specific cancer types overall and by sex calling for efforts to develop disease-specific prevention programmes. In people with schizophrenia, higher risk generally occurs in those <75 years.

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Section: Comparison With Previous Studiessupporting

confidence: 86%

The overall and sex- and age-group specific incidence rates of cancer in people with schizophrenia: a population-based cohort study

Pettersson

Gissler

Hällgren

et al. 2020

Epidemiol Psychiatr Sci

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show abstract

“…Meta-regression between the gap in screeing rates between the general population and subjects with mental illness, and the screening rates in the general population. (116) no data available Aggarwal, 2010 (117) no data available Andreassen, 2019 (118) no data available Baughman, 2016 (119) no data available Bires, 2016 (120) no data available Burke, 2017 (121) no data available Caruso, 2012 (122) no data available…”

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confidence: 99%

Disparities in cancer screening in people with mental illness across the world versus the general population: prevalence and comparative meta-analysis including 4 717 839 people

Solmi

Firth

Miola

et al. 2020

The Lancet Psychiatry

125

126

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Background. Since people with mental illness more likely die from cancer, we assessed whether people with mental illness undergo less cancer screening versus the general population. Methods. Systematic review and meta-analysis of observational studies. Primary outcome was Odds Ratio (OR) of cancer screening in people with mental illness versus the general population. Secondary outcome was prevalence of cancer screening in mental illness. Sensitivity and subgroup analyses considered specific mental illness, diagnostic criteria, confounder adjustment, country/region, and program vs. opportunistic screening. Newcastle-Ottawa Scale was used to assess study quality. This study is registered with PROSPERO, number CRD42018114781.

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“…Some epidemiological studies declared that schizophrenia has a lower cancer incidence, while the evidence of schizophrenia has a higher risk of cancer also be reported 13-16. Even in the same kind of cancer, the result would be very different 17. An interesting epidemiologic study demonstrated that schizophrenic patients who have elevated DRD2 signaling, the risk of cancers would be increased, and DRD2 antagonists make this risk return to normal 18-20.…”

Section: Introductionmentioning

confidence: 99%

The Prospective Value of Dopamine Receptors on Bio-Behavior of Tumor

Wang¹,

Wang²,

Luo³

et al. 2019

J. Cancer

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Dopamine receptors are belong to the family of G protein-coupled receptor. There are five types of dopamine receptor (DR), including DRD1, DRD2, DRD3, DRD4, and DRD5, which are divided into two major groups: the D1-like receptors (DRD1 and DRD5), and the D2-like receptors (DRD2, DRD3, and DRD4). Dopamine receptors are involved in all of the physiological functions of dopamine, including the autonomic movement, emotion, hormonal regulation, dopamine-induced immune effects, and tumor behavior, and so on. Increasing evidence shows that dopamine receptors are associated with the regulation of tumor behavior, such as tumor cell death, proliferation, invasion, and migration. Recently, some studies showed that dopamine receptors could regulate several ways of death of the tumor cell, including apoptosis, autophagy-induced death, and ferroptosis, which cannot only directly affect tumor behavior, but also limit tumor progress via activating tumor immunity. In this review, we focus mainly on the function of the dopamine receptor on Bio-behavior of tumor as a potential therapeutic target.

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Cancer prevalence in Israeli men and women with schizophrenia

Cited by 7 publications

References 33 publications

The overall and sex- and age-group specific incidence rates of cancer in people with schizophrenia: a population-based cohort study

The overall and sex- and age-group specific incidence rates of cancer in people with schizophrenia: a population-based cohort study

Disparities in cancer screening in people with mental illness across the world versus the general population: prevalence and comparative meta-analysis including 4 717 839 people

The Prospective Value of Dopamine Receptors on Bio-Behavior of Tumor

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