Cancer phototherapy with nano-bacteria biohybrids

Lu, Hongfei; Niu, Ling; Yu, Lin; Jin, Kai; Zhang, Jing; Liu, Jinliang; Zhu, Xiaohui; Wu, Yihan; Zhang, Yong

doi:10.1016/j.jconrel.2023.06.009

Cited by 6 publications

(3 citation statements)

References 159 publications

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“…Remarkable progress has been made in the research of utilizing bacteria as a natural biomimetic nano-system for drug delivery in RA treatment. Studies primarily focus on harnessing the unique attributes of bacteria, such as their inherent targeting capabilities, programmability, and biocompatibility, to develop novel therapeutic approaches ( 66 , 67 ). Through genetic engineering techniques, researchers have successfully engineered bacteria to target inflammatory sites in RA and subsequently release anti-inflammatory drugs or bioactive molecules, including anti-inflammatory proteins, immune modulators, siRNA, and miRNA, upon reaching the designated location.…”

Section: Drugs Delivery Systemmentioning

confidence: 99%

Natural biomimetic nano-system for drug delivery in the treatment of rheumatoid arthritis: a literature review of the last 5 years

Li,

Zhuang

2024

Front. Med.

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Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized primarily by synovitis, leading to the destruction of articular cartilage and bone and ultimately resulting in joint deformity, loss of function, and a significant impact on patients’ quality of life. Currently, a combination of anti-rheumatic drugs, hormonal drugs, and biologics is used to mitigate disease progression. However, conventional drug therapy has limited bioavailability, and long-term use often leads to drug resistance and toxic side effects. Therefore, exploring new therapeutic approaches for RA is of great clinical importance. Nanodrug delivery systems offer promising solutions to overcome the limitations of conventional drugs. Among them, liposomes, the first nanodrug delivery system to be approved for clinical application and still widely studied, demonstrate the ability to enhance therapeutic efficacy with fewer adverse effects through passive or active targeting mechanisms. In this review, we provide a review of the research progress on the targeting mechanisms of various natural biomimetic nano-delivery systems in RA therapy. Additionally, we predict the development trends and application prospects of these systems, offering new directions for precision treatment of RA.

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Section: Drugs Delivery Systemmentioning

confidence: 99%

Natural biomimetic nano-system for drug delivery in the treatment of rheumatoid arthritis: a literature review of the last 5 years

Li,

Zhuang

2024

Front. Med.

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“…In cancer therapy, phototherapy is vital for impairing progression of cancer cells and it can increase ROS generation or mediate hyperthermia to trigger tumor ablation. More information regaerding phototherapy-mediated tumor ablation can be found in recent reviews [187] , [188] , [189] , [190] , [191] . The first type of phototherapy is photothermal therapy (PDT) that aims in development of nano-scale delivery systems for photosensitizers and sometimes, chemotherapy drugs are also loaded on nanoparticles to mediate combination of phototherapy and chemotherapy.…”

Section: Phototherapy and Light-responsive Liposomesmentioning

confidence: 99%

Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy

Samaei,

Daryab,

Gholami

et al. 2024

Translational Oncology

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“…Public opinion about GMOs is often divided, with concerns about their safety, ethics, and potential environmental impact contributing to skepticism and resistance. [167][168][169][170] In light of this, fostering public trust and acceptance is critical for the successful implementation of GEB applications in healthcare. This can be achieved through transparent communication about the benefits and risks of GEB, as well as the measures taken to ensure their safety.…”

Section: Challenges and Perspectivesmentioning

confidence: 99%