Cancer Pain and Therapy

Brozović, Gordana

doi:10.20471/acc.2022.61.s2.13

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Un opioide potente sigue siendo el fármaco de elección para tratar el dolor moderado o intenso en pacientes con cáncer avanzado. Las investigaciones futuras deberían centrarse en definir la eficacia de los AINE, los antidepresivos, los anticonvulsivos, los corticosteroides y el posible papel de los enfoques no farmacológicos en el tratamiento del dolor en pacientes con cáncer avanzado (Brozović et al, 2022).…”

Section: Dolorunclassified

Atención de enfermería basada en los principios básicos de los cuidados paliativos integrales para pacientes oncológicos.

Hurtado Hurtado

2024

ReSoFro

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Durante las últimas décadas, los cuidados paliativos han evolucionado como una especialidad interprofesional, centrándose en mejorar la calidad de vida de pacientes con enfermedades terminales, especialmente en el contexto del cáncer, donde el tratamiento puede ser largo y problemático. Los cuidados paliativos son cruciales para abordar los síntomas físicos y psicológicos que afectan a los pacientes en esta etapa. Las enfermeras desempeñan un papel fundamental en esta área, brindando cuidados individualizados y coordinando la atención para mejorar la calidad de vida de los pacientes. Esta revisión bibliográfica tiene como objetivo sintetizar estrategias innovadoras en la atención de enfermería para pacientes oncológicos bajo cuidados paliativos. Se llevó a cabo una exhaustiva búsqueda de artículos relevantes publicados entre 2017 y 2023 en bases de datos reconocidas, utilizando criterios rigurosos de selección. La literatura respalda la importancia de la participación de equipos de cuidados paliativos en la mejora de la atención a pacientes con cáncer, lo que se refleja en la creciente demanda de enfermeras especializadas en este campo a nivel mundial. Se destaca la necesidad de una atención integral que aborde no solo los aspectos físicos, sino también los emocionales, sociales y espirituales del paciente. En conclusión, el personal de enfermería desempeña un papel importante en la atención integral, proporcionando apoyo emocional y espiritual que contribuye significativamente al bienestar de los pacientes y sus familias durante esta etapa difícil.

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Section: Dolorunclassified

Atención de enfermería basada en los principios básicos de los cuidados paliativos integrales para pacientes oncológicos.

Hurtado Hurtado

2024

ReSoFro

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“…Consequently, paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) are employed to address mild pain in patients, whereas mild and potent opioids such as codeine, tramadol, and morphine are utilized for the management of moderate to severe pain (61,62). Accurately defining the type of cancer pain that a patient is experiencing is crucial, as it may necessitate the implementation of additional strategies like adjuvant analgesia (using antiepileptic or antidepressant drugs), corticosteroids, radiotherapy, and interventional procedures (63). For instance, neuropathic pain can be partially treated by combining opioids with antiepileptic or antidepressant drugs (64,65).…”

Section: Is a Tumor Always Painful And What Is Exactly Cancer Pain?mentioning

confidence: 99%

From pain to tumor immunity: influence of peripheral sensory neurons in cancer

Mardelle,

Bretaud,

Daher

et al. 2024

Front. Immunol.

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The nervous and immune systems are the primary sensory interfaces of the body, allowing it to recognize, process, and respond to various stimuli from both the external and internal environment. These systems work in concert through various mechanisms of neuro-immune crosstalk to detect threats, provide defense against pathogens, and maintain or restore homeostasis, but can also contribute to the development of diseases. Among peripheral sensory neurons (PSNs), nociceptive PSNs are of particular interest. They possess a remarkable capability to detect noxious stimuli in the periphery and transmit this information to the brain, resulting in the perception of pain and the activation of adaptive responses. Pain is an early symptom of cancer, often leading to its diagnosis, but it is also a major source of distress for patients as the disease progresses. In this review, we aim to provide an overview of the mechanisms within tumors that are likely to induce cancer pain, exploring a range of factors from etiological elements to cellular and molecular mediators. In addition to transmitting sensory information to the central nervous system, PSNs are also capable, when activated, to produce and release neuropeptides (e.g., CGRP and SP) from their peripheral terminals. These neuropeptides have been shown to modulate immunity in cases of inflammation, infection, and cancer. PSNs, often found within solid tumors, are likely to play a significant role in the tumor microenvironment, potentially influencing both tumor growth and anti-tumor immune responses. In this review, we discuss the current state of knowledge about the degree of sensory innervation in tumors. We also seek to understand whether and how PSNs may influence the tumor growth and associated anti-tumor immunity in different mouse models of cancer. Finally, we discuss the extent to which the tumor is able to influence the development and functions of the PSNs that innervate it.

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“…It has been reported that commonly used radiotherapy techniques can improve the tumor microenvironment (TME) to some extent [21,22] . However, radiotherapy treatment for prostate cancer commonly results in unavoidable adverse side effects, including lower urinary tract symptoms, intestinal complications, erectile dysfunction, and myelosuppression, which limits the application of radiotherapy in patients [23] . In the previous study, we reported that radiated tumor cell-derived microparticles (RMPs) are the main medium of the bystander effect induced by radiotherapy [24] .…”

Section: Introductionmentioning

confidence: 99%

Irradiated Microparticles Suppress Prostate Cancer by Tumor Microenvironment Reprogramming and Ferroptosis

Deng,

Li,

Yang

et al. 2024

Preprint

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Immunogenic cell death (ICD) plays a crucial role in triggering the antitumor immune response in the tumor microenvironment (TME) through the release of damage-associated molecular patterns (DAMPs). Recently, considerable attention has been dedicated to ferroptosis, a type of ICD that is induced by intracellular iron and has been demonstrated to change the immune desert status of the TME. However, there remains significant room for improvement among strategies for inducing high levels of ICD through ferroptosis to fight cancers that are characterized by an immune desert, such as prostate cancer. Radiated tumor cell-derived microparticles (RMPs) are radiotherapy mimetics that have been shown to activate the cGAS-STING pathway, induce tumor cell ferroptosis, and inhibit M2 macrophage polarization. RMPs can also act as carriers of agents with remarkable biocompatibility. In the present study, we designed a therapeutic system wherein the ferroptosis inducer RSL-3 was loaded into RMPs to treat prostate cancer, which is considered a cold tumor, using in vitro and in vivo models involving RM-1 prostate carcinoma cells. Apoptosis inducer CT20 peptide (CT20p) was also added into the RMPs to aggravate ICD. In vitro experiments demonstrated that RSL-3- and CT20p-loaded RMPs (RC@RMPs) led to ferroptosis and apoptosis of RM-1 cells, and CT20p had a synergistic effect on ferroptosis by promoting ROS production and mitochondrial instability. RC@RMPs elevated the dendritic cell (DC) expression of MHCⅡ, CD80, and CD86 and facilitated M1 macrophage polarization. In a syngeneic mouse model of prostate cancer induced by RM-1 cells, RC@RMPs significantly inhibited tumor growth and prolonged survival time via DC activation, macrophage reprogramming, enhancement of CD8+ T cell presence, and proinflammatory cytokine production, without diffusing outside the tumor tissue. Moreover, combination treatment with anti-PD-1 showed improved effectiveness to inhibit RM-1 progression. This method provides a novel strategy for the synergistic enhancement of ICD for prostate cancer immunotherapies.

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Cancer Pain and Therapy

Abstract: Pain is the commonest presenting feature that leads to a diagnosis of cancer and remains the most feared symptom by patients throughout the course of the disease. Beuken-van Everdingen showed that pain prevalence rises with disease progression and affect

Cited by 8 publications

References 23 publications

Atención de enfermería basada en los principios básicos de los cuidados paliativos integrales para pacientes oncológicos.

Atención de enfermería basada en los principios básicos de los cuidados paliativos integrales para pacientes oncológicos.

From pain to tumor immunity: influence of peripheral sensory neurons in cancer

Irradiated Microparticles Suppress Prostate Cancer by Tumor Microenvironment Reprogramming and Ferroptosis

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