Cancer of the vulva

Abstract

Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. There is no specific screening and the most effective strategy to reduce vulvar cancer incidence is the opportune treatment of predisposing and preneoplastic lesions associated with its development. While vulvar cancer may be asymptomatic, most women present with vulvar pruritus or pain, or have noticed a lump or ulcer. Therefore, any suspicious vulvar lesion should be biopsied to exclude invasion. Once established, the most common subtype is squamous cell carcinoma. Treatment of vulvar cancer depends primarily on histology and surgical staging. Treatment is predominantly surgical, particularly for squamous cell carcinoma, although concurrent chemoradiation is an effective alternative, particularly for advanced tumors. Management should be individualized, and carried out by a multidisciplinary team in a cancer center experienced in the treatment of these tumors.

The effect of lymph node metastasis on overall survival and disease-free survival in vulvar cancer patients

“…In accordance with these studies, the mean age of the patients at time of diagnosis was lower in our study. Surgery is recommended both for staging and optimal treatment in vulvar cancer patients [2]. However, elder patients with medical comorbidities who cannot undergo surgery or those with advanced disease (in whom it is thought that the tumor will not be dissected with negative surgical margins) are managed with RT or CRT [2].…”

“…Surgery is recommended both for staging and optimal treatment in vulvar cancer patients [2]. However, elder patients with medical comorbidities who cannot undergo surgery or those with advanced disease (in whom it is thought that the tumor will not be dissected with negative surgical margins) are managed with RT or CRT [2]. The management of vulvar cancer should be individualized by multidisciplinary teamwork [3,4].…”

“…In convenient with the literature, tumor diameter had no effect on DFS and OS in our study. Most recurrences occur in the surgical field, so surgical margin status is an important factor in vulvar cancer [2]. The tumor is recommended to be dissected with at least 1 cm margin in NCCN and ESGO guidelines [3,4].…”

“…The incidence of vulvar cancer was reported to be 1.1 per 100.000 women in Poland [1]. Surgery is the mainstay treatment for early stage vulvar cancer [2][3][4]. However, definitive radiotherapy (RT) and chemo-radiotherapy (CRT) should be selected in patients with distant metastasis, locally advanced disease and older patients with medical comorbidities that are not fit for surgery [4].…”

Ultrasound‐guided FNA cytology of groin lymph nodes improves the management of squamous cell carcinoma of the vulva: Results from a comparative cytohistological study

“…It is generally classified into 2 different types: the first is related to human papillomavirus (HPV) infection, while the second, often occurring in elderly patients, is an HPV-independent type. 1 Because SCC frequently spreads to the regional lymph nodes, (from the vulva to superficial and then Cancer Cytopathology August 2019 deep inguinal groups), the standard treatment is represented by either radical or wide local excision followed by bilateral inguinofemoral lymphadenectomy according to the depth of tumor invasion, with a cutoff of >1 mm. 2 Radiotherapy is also performed if the tumor involves a lymph node or the vulvar margins.…”