Cancer of the uterine cervix in Aberdeenshire. Epidemiological aspects.

Aitken-Swan, Jean; Baird, Donna D.

doi:10.1038/bjc.1966.75

Cited by 26 publications

(10 citation statements)

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“…Comparison of the incidence in different ethnic groups who practice and do not practice circumcision suggests that it does, but when husbands of patients and controls in more homogeneous populations are compared there is less evidence of an association. A recent study (Aitken-Swan and Baird, 1965), based on the physical examination of husbands of women interviewed for the present inquiry, found no significant difference in length of foreskin between husbands of women with and without cancer of the cervix.…”

Section: Circumcisioncontrasting

confidence: 50%

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Cancer of the uterine cervix in Aberdeenshire. Aetiological aspects.

Aitken-Swan¹,

Baird²

1966

Br J Cancer

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EPIDEMIOLOGICAL aspects of clinical cancer of the cervix in Aberdeenshire were discussed in the preceding article (Aitken-Swan and Baird, 1966). This paper presents the results of a supplementary study of social and environmental factors thought to be of significance in the aetiology of the disease. Three groups of women were interviewed by one of us (J.A.-S.).Patients with clinical cancer: These were Aberdeenshire patients first attending hospital during the years 1961-63. Through the co-operation of Professor James Walker, numbers were augmented by the inclusion of all patients living in the city of Dundee who first attended a hospital there between 1958-63 and who were available for interview.Patients with pre-clinical cancer: Since April, 1958, gynaecological and obstetrical patients, women attending various clinics or registered with certain general practices in the city have been screened by a cytological team based on the University Department of Obstetrics and Gynaecology. The opportunity was taken to interview the first 143 ever-married women with pre-invasive cancer (sometimes known as carcinoma-in-situ) or microinvasive cancer of the cervix diagnosed by cytology and subsequent histology. Later, 57 women living in country districts were added, bringing the total to 200.A control group without cancer: These were selected from ever-married women taking part in the cytology campaign, matched to the group with pre-clinical cancer for age, number of pregnancies, city or country residence and source of contact with the campaign (post-natal clinic, gynaecological ward, general practice, etc.) Seventy per cent could be matched in all particulars, 27 per cent differed by one year of age only and 3 per cent differed by more than this. The factors considered include age, marital state, coitus, marriage and pregnancies, circumcision and contraception. Some of these factors could be studied in patients who were not interviewed, as a detailed obstetrical history and certaini social data were routinely recorded in the medical case-notes. Interviews were at the woman's home by appointment. Numbers are as follows: Total Interviewed

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Section: Circumcisioncontrasting

confidence: 50%

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mentioning

confidence: 99%

Cancer of the uterine cervix in Aberdeenshire. Aetiological aspects.

Aitken-Swan¹,

Baird²

1966

Br J Cancer

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“…Because interview data on these topics may be of dubious accuracy, some researchers have substituted questions about age at first marriage and number of marriages, and the results have been comparable. 2 Furthermore, women at high risk include those with broken marriages [3][4][5][6][7][8] and women whose husbands have multiple partners or extramarital relationships. 1,9 Rates of this disease are lower for single women, 3,7,10,11 and nuns are rarely afflicted.…”

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confidence: 99%

“…2 Furthermore, women at high risk include those with broken marriages [3][4][5][6][7][8] and women whose husbands have multiple partners or extramarital relationships. 1,9 Rates of this disease are lower for single women, 3,7,10,11 and nuns are rarely afflicted. 12,13 Early age at first pregnancy increases the cervical cancer risk in most studies evaluating this variable.…”

mentioning

confidence: 99%

“…However, a report on a cytology screening program in the Barbados demonstrated an independent effect on number of pregnancies increasing the risk of positive Papanicolaou smears. 17 Women of relatively low socioeconomic status, as measured by education 6,7 or husband's occupation, 3,6,11,18 tend to develop the disease more frequently than women of higher status.…”

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Prevalence of Carcinoma in situ and Squamous Dysplasia of the Uterine Cervix in Riyadh, Saudi Arabia

et al. 1988

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Historical risk factors of etiologic significance were evaluated in a seroepidemiological prospective study of carcinoma in situ and squamous dysplasia of the uterine cervix among Saudi women in Riyadh. A total of 2,476 women were screened with Papanicolaou smears, and blood samples and cervical swabs were taken for serological study and tissue culture. The results of this investigation show that, although population-based incidence data for Saudi women are generally lacking, the rates of carcinoma in situ and squamous dysplasia of the uterine cervix are very low among Saudis. The related data indicate that in spite of their relatively low mean age at first marriage, at onset of coitus, and at first pregnancy, and an exceptionally high pregnancy rate, the overwhelming majority of screened women had normal cytology (97.6%), while atypical squamous cells were detected in only 2.4% of the sample. Herpesvirus was isolated in 0.5% of the sample, while all these had normal cytology. The findings of this study are consistent with the results of other similar studies on the populationbased data for low-risk groups; the very low rate of cervical malignancies may be ascribed to religious teaching which strongly discourages extramarital relationships, and which also results in low rates of illegitimacy and venereal disease. MeSH KEYWORDS: Carcinoma in situ; Dysplasia, squamous cell; Uterine neoplasms-occurrence; Cervix neoplasms; Cervix dysplasia MORE THAN A century of studies and speculations has been spent on the search for epidemiologic factors of etiologic significance in the onset of carcinoma in situ of the uterine cervix. In this search, three major evidential currents have emerged: (1) demographic resolution of increased risk of women culturally identified by social deprivation and early marriage, (2) epidemiological focus upon sexuality as the core biological association, with early coitus and multiple consorts as the specifically effective components maximizing the risk, and (3) the

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Area of residence and risk of cancer of the cervix uteri in ireland

Herity

1989

I.J.M.S.

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A study of 85 women attending a national centre for treatment of invasive squamous cell carcinoma of the cervix uteri (SCC) and 85 age-matched female controls attending the same centre showed no significant difference for area of residence. A previously reported excess of rural women among cases was probably an artefact of sample selection. An increased risk for women resident in urban areas described in studies elsewhere is not apparent in the women studied and demographic features of the Irish population may influence this result.

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Cancer of the uterine cervix in Aberdeenshire. Epidemiological aspects.

Cited by 26 publications

References 10 publications

Cancer of the uterine cervix in Aberdeenshire. Aetiological aspects.

Cancer of the uterine cervix in Aberdeenshire. Aetiological aspects.

Prevalence of Carcinoma in situ and Squamous Dysplasia of the Uterine Cervix in Riyadh, Saudi Arabia

Area of residence and risk of cancer of the cervix uteri in ireland

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