Cancer of the Thyroid

Bell, George O.

doi:10.1016/s0025-7125(16)32047-8

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…In general, our results agree with previous studies (Crile, 1953;Halnan, 1966;Bell, 1975;Staunton & Skeet, 1979;Byar et al, 1979) Distinction of the histological subtypes of thyroid cancer has been codified by Hedinger & Sobin (1974) and it is clear that microscopic tumour type is probably the most important determinant of survival. It is possible that more widespread use of immunocytochemical techniques with definition of specific tumour markers may help to describe further immunohistological groups (dependent on marker expression) with refinement of prognostic models.…”

Section: Discussionsupporting

confidence: 93%

“…Among these are age, sex, histological subtype and the extent of disease at the time of diagnosis (Crile, 1953;Halnan, 1966;Bell, 1975;Staunton & Skeet, 1979;Byar et al, 1979). Thyroid cancer is a rare disease (annual incidence rate of 1.5 per 100,000 of the population in Scotland) and thus improvements in assessment and refinement of prognostic models cannot be based on randomised trials since these are likely to be too small to have high statistical power. We present data here from 441 consecutive patients with thyroid carcinoma referred for treatment to a single population based referral centre.…”

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confidence: 99%

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Prognostic factors in thyroid tumours

Kerr¹,

Burt²,

Boyle³

et al. 1986

Br J Cancer

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Prognostic factors in thyroid tumours

Kerr¹,

Burt²,

Boyle³

et al. 1986

Br J Cancer

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“…In general, our results agree with previous studies (Crile, 1953;Halnan, 1966;Bell, 1975;Staunton & Skeet, 1979;Byar et al, 1979) that microscopic tumour type, age at diagnosis, the extent of the primary tumour, lymph node status and the presence of metastases influence survival in patients with thyroid carcinoma. In addition we have demonstrated that specific symptom and sign clusters suggestive of local tumour invasion are also correlated with prognosis.…”

Section: Discussionsupporting

confidence: 93%

“…A number of factors are known to be of prognostic importance in thyroid carcinoma. Among these are age, sex, histological subtype and the extent of disease at the time of diagnosis (Crile, 1953;Halnan, 1966;Bell, 1975;Staunton & Skeet, 1979;Byar et al, 1979). Thyroid cancer is a rare disease (annual incidence rate of 1.5 per 100,000 of the population in Scotland) and thus improvements in assessment and refinement of prognostic models cannot be based on randomised trials since these are likely to be too small to have high statistical power.…”

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confidence: 99%

Talk of the Towns

1998

Environmental Health Perspectives

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Using Cox's Proportional Hazard Model, we have demonstrated the influence of age, sex, microscopic tumour type, extent of primary tumour, nodal status and the presence of metastases on prognosis, in our population of 441 patients with thyroid carcinoma. The TNM classification contributes significantly to survival, but does not include other contributory prognostic variables, whereas the prognostic index developed by the EORTC thyroid study group, which takes account of age and histology, proved a reliable predictor of survival for our patient group.

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“…Most authors (Halnan, 1966;Bell, 1975;Russell et al, 1975;Cady, 1976) agree with Crile (1953) that increasing age carries an inverse relationship to survival. McKenzie (1971) found the effect limited to 'differentiated' tumours ; Franssila (1975) agreed, but only in follicular cancers did this reach significance.…”

Section: Agementioning

confidence: 95%

Thyroid cancer: Prognosis in 469 patients

Staunton

Skeet²

1979

Journal of British Surgery

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A computer study of 469patients with thyroid cancer is p.esented. There were 40 per cent anaplastic, 30 per cent papillary, 15 per cent follicular and 15 per cent rarer tumours. The 20-year survival was 7.5 per cent for anaplastic, 55 per cent for papillary and 35 per cent for follicular carcinoma. The ~o m i n a~~ role of histology in prognosis is confirmed.Other important factors are: all patients under 45 reap benefit; females survive longer than males with papillary and follicular tumours. Cervical node metastases confer no depression in papillary tumours. Local tumour advance depresses survival but facilitates diagnosis. We find merit in the T N M classification, but warn against overelaboration.We regret our failure to assess the differential eflect of individual treatment, which poses a continuing challenge to oncologists.ACCURACY in prognosis allows rational management of cancer. For common cancers, such as those of the lung or stomach, it required years of labour to achieve the present degree of knowledge of their behaviour. So much more difficult is it to reach the same level of knowledge about a rare cancer, such as that of the thyroid, with the added difficulty of its many variants. Thus, there is a need for reports on thyroid cancer from as many centres as possible, particularly from hospitals where relatively large numbers are treated and the patients are followed through life. Patients and methods

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Cancer of the Thyroid

Cited by 8 publications

References 48 publications

Prognostic factors in thyroid tumours

Prognostic factors in thyroid tumours

Talk of the Towns

Thyroid cancer: Prognosis in 469 patients

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