Cancer of the Oral Cavity

Montero, Pablo H.; Patel, Snehal G.

doi:10.1016/j.soc.2015.03.006

Cited by 471 publications

(458 citation statements)

References 80 publications

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“…With advanced disease, functional limitation such as difficulty in speaking and swallowing may occur. Box 1 lists symptoms based on the site of the lesion 2122…”

Section: How Do Patients Present?mentioning

confidence: 99%

Tobacco related oral cancer

Chaturvedi

Singh

Chien

et al. 2019

BMJ

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“…With advanced disease, functional limitation such as difficulty in speaking and swallowing may occur. Box 1 lists symptoms based on the site of the lesion 2122…”

Section: How Do Patients Present?mentioning

confidence: 99%

Tobacco related oral cancer

Chaturvedi

Singh

Chien

et al. 2019

BMJ

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“…1,2 Additionally, in many European countries, the incidence of OSCC has been increasing. 3,4 Consequently, more effective strategies and classifications for oral squamous cell cancer are in dire need. Despite advances in therapeutic strategies during the last years including novel surgical techniques and adjuvant (chemo) radiotherapy schedules, the prognosis for OSCC is still relatively poor: The 5-year survival rate of OSCC is less than 50% due to high rates of local or nodal recurrence.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

et al. 2019

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Background MicroRNAs (miRNA) recently evolved as potential cancer biomarkers. Therefore, the aim of the present study was to evaluate the prognostic impact of eight miRNAs connected to oral squamous cell carcinoma (OSCC). Method Expression levels of hsa‐mir‐21‐5p, hsa‐mir‐29b‐3p, hsa‐mir‐31‐5p, hsa‐mir‐99a‐5p, hsa‐mir‐99b‐3p, hsa‐mir‐100‐5p, hsa‐mir‐143‐3p and hsa‐mir‐155‐5p were analyzed in tumor tissue (n = 36) and healthy oral mucosal tissue (n = 17) and correlated with clinical variables. Results of the study cohort were validated in an OSCC cohort of The Cancer Genome Atlas. Results Increased hsa‐mir‐99b‐3p expression level showed a tendency toward advanced tumor stages, and high levels of hsa‐mir‐100‐5p expression were associated with extracapsular extension. While a high expression level of hsa‐mir‐99b‐3p was associated with better survival, a high expression level of hsa‐mir‐100‐5p was correlated with a poorer survival in the study cohort. Conclusion Our results indicate that hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p may serve as novel prognostic biomarkers in OSCC.

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“…The incidence is on the rise, with the National Cancer Institute predicting nearly 50 thousand new cases in the United States in 2016 (42,440 in 2014), with almost 10 thousand (8,300 in 2014) deaths . Although tobacco use and alcohol consumption remain the main risk factors for cancer development, human papillomavirus (HPV) infection was proven to play a role in oral cancer etiology . Contrary to oropharynx cancer, for which 40% to 60% of all cancer cases are HPV‐positive, only about 5% to 15% of oral cavity tumors are HPV‐positive—and the data available in literature is inconsistent .…”

Section: Introductionmentioning

confidence: 99%