“…Less than two decades ago, following radiation therapy alone, patients who had stage III or IV nasopharyngeal cancer generally had a substantial incidence (50%-80%) of local recurrence (Hoppe et al 1976;Perez et al 1969;Scanlon et al 1967;Cooper et al 1983;Ahmad and Stefani 1986;Dimery et al 1979) and a relatively high (approximately 30%) risk of distant dissemination of disease. To some degree, the failure of radiation therapy could be attributed to late diagnosis resulting in the discovery of some tumors that were so large or so resistant to radiation that any attempt would fail and to some degree the failure refl ected limitations of the techniques then available.…”