Cancer of the gastric stump after partial gastrectomy (Billroth II principle) for ulcer

Saegesser, F; James, DiSario A

doi:10.1002/1097-0142(197205)29:5<1150::aid-cncr2820290505>3.0.co;2-5

Cited by 73 publications

(26 citation statements)

References 8 publications

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“…In these cancers foveolar hyperplasia rather than intestinal metaplasia may be the lesion predisposing to the development of carcinomas. [24][25][26][27][28] This study was supported by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.…”

Section: Discussionmentioning

confidence: 99%

Morphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach.

Hattori¹

1985

Journal of Clinical Pathology

113

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SUMMARY A morphological range of 67 hyperplastic polyps was studied. They included polyps removed endoscopically and polyps found incidentally in resected stomachs with gastric ulcers and cancer. The hyperplastic polyps were essentially composed of cystic foveolae and pyloric type glands, lined by cells identical to those of the normal gastric mucosa. Thirty one polyps contained other cytological elements. In 18, intestinal metaplasia was seen; the tubules were mostly composed of columnar and goblet cells and lacked Paneth cells. In 11 polyps, nine cases of gastric dysplasia and two cases of intestinal dysplasia, dysplastic changes were found. The former consisted of a proliferation of irregularly shaped pits with pleomorphic cuboidal/columnar cells with relatively basophilic cytoplasm. They contained mucigen granules of a gastric type. The latter consisted of atypical pits composed of closely packed, tall column.ar and small goblet cells, both resembling adenomatous cells of the colon. In three polyps carcinomas were seen, one of which was an intestinal type adenocarcinoma. In the other two, the cancer cells closely resembled the normal foveolar cells, containing gastric type mucigen granules. They were gastric type adenocarcinomas.

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Section: Discussionmentioning

confidence: 99%

Morphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach.

Hattori¹

1985

Journal of Clinical Pathology

113

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“…Carcinoma of the gastric stump as a late complication of resection for benign disease is a well-recognised clinical entity (Saegesser and James, 1972;Morgenstern et al, 1973). There have been a number of reports of an increased incidence of stump carcinoma compared with carcinoma in the normal population (Krause, 1958;Schrumpf et al, 1977), although some authors have drawn the opposite conclusion (Liavaag, 1962).…”

mentioning

confidence: 99%

Histological appearances of the gastric mucosa 15--27 years after partial gastrectomy.

Savage¹,

Jones²

1979

J Clin Pathol

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SUMMARY Sixty-three patients, who had had a partial gastrectomy 15-27 years previously, were examined by endoscopy and multiple mucosal biopsies. No patient had a completely normal gastric mucosa; they showed varying degrees of gastritis, intestinal metaplasia, and dysplasia; 21 % had significant dysplasia, and these are regarded as an 'at-risk' group requiring frequent follow-up examinations. One patient had severe dysplasia (carcinoma-in-situ), but no case of infiltrating carcinoma was found.

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“…An increased risk of gastric cancer in stomach remnants long after partial gastrectomy and possibility of effects of reflux of bile and/or pancreatic juice have been reported 45 . Promoting effects of bile on experimental stomach tumorigenesis in the rat have also been suggested [46][47][48] and it has been shown that the incidence of gastric cancers induced by carcinogens is increased after partial gastrectomy, with tumor development related to the promotional effect of bile reflux 49 .…”

Section: Bilementioning

confidence: 99%

Significant Factors on Gastric Carcinogenesis Revealed by Experimental Animal Models

2006

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Abstract:The pathological and molecular biochemical analyses in the experimental animal models are important for the solutions of human disorders, including stomach cancer. Stomach cancers are induced experimentally by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) in rats and mice. Helicobacter pylori (H. pylori) is one of the most important factor in the human stomach disorders, and the H. pylori infected and chemical carcinogen treated Mongolian gerbil (MG) has thus proved very useful for the analysis of human stomach carcinogenesis. Intestinal metaplasia is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of stomach cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell, while the pepsinogen altered pyloric glands can be regarded as a common change in rodents, acting as a precursor for a variety of adenocarcinoma types. As the results of the analyses of the MG model, H. pylori is a strong promoter of gastric carcinogenesis rather than an initiator. The dose-dependent enhancing effects of salt on stomach carcinogenesis are demonstrated in the MGs treated with MNU and H. pylori, although high salt intake has a minor influence compared to H. pylori. Bile reflux is not an initiator, but rather an important promoter in the carcinogenesis of gastric stump after partial gastrectomy. Stomach cancers develop from single cells, based on data from clonality analysis in C3H/HeN⇔BALB/c chimeric mice. Intestinalization progresses from gastric, through gastric-and-intestinal mixed, to intestinal phenotypes in non-cancerous and cancerous tissue independently. The chemopreventive effects of H. pylori eradication and reduction of salt intake against stomach cancer are confirmed in the MG models. (J Toxicol Pathol 2006; 19: 75-86)

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Cancer of the gastric stump after partial gastrectomy (Billroth II principle) for ulcer

Cited by 73 publications

References 8 publications

Morphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach.

Morphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach.

Histological appearances of the gastric mucosa 15--27 years after partial gastrectomy.

Significant Factors on Gastric Carcinogenesis Revealed by Experimental Animal Models

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