Cancer of the Gastric Cardia is Rising in Incidence in an Asian Population and is Associated with Adverse Outcome

Deans, Chris; Yeo, Matthew Sze‐Wei; Soe, Mu Yar; Shabbir, Asim; Ti, Thiow Kong; So, Jimmy Bok-Yan

doi:10.1007/s00268-010-0935-0

Cited by 126 publications

(101 citation statements)

References 39 publications

(44 reference statements)

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“…Recent studies indicate that the incidence rate of gastric cardia cancer is as high as esophageal cancer in the high-incidence area of esophageal cancer. Epidemiological studies also have reported an increasing incidence of gastric cardia cancer in some Asian countries during the past few decades (Blaser et al, 2002;Tony et al, 2007;Kusano et al, 2008;Zhou et al, 2008;Deans et al, 2011), owning to the development of the early diagnosis of gastric cardia cancer and its clear definition. Screening program of esophageal and gastric cardia cancer screening of Linzhou in [2005][2006] has proofed it and has also showed the rise of the ratio of esophageal to gastric cardia cancer.…”

Section: Introductionmentioning

confidence: 99%

A Population-based Case-control Study on Risk Factors for Gastric Cardia Cancer in Rural Areas of Linzhou

Sun¹,

Chang²,

Cui³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Gastric cancer is the second most common cause of cancer-related deaths in the world. Although certain dietary factors and lifestyles have been suggested to be associated with gastric carcinogenesis, there have been few investigations focusing on rural areas. A case-control study was therefore carried out to investigate the risk factors of gastric cardia cancer (GCC) in rural areas of Linzhou. A total of 470 newly diagnosed cases of GCC and 470 healthy controls were included. Face-to-face interviews were conducted, using a uniform questionnaire containing questions on demographics, per capita income, living habits, dietary habits and family history of tumors. The relationship between putative risk factors and GCC was assessed by odds ratios (

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Section: Introductionmentioning

confidence: 99%

A Population-based Case-control Study on Risk Factors for Gastric Cardia Cancer in Rural Areas of Linzhou

Sun¹,

Chang²,

Cui³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Data from prior Asian studies have been inconsistent with regard to the incidence of GCA. Some showed an increase in incidence in Japanese, Chinese, Korean, Singaporean and South Indian populations while others showed no change [19][20][21][22][23][24]. A metaanalysis by Corley et al showed that there was no clear association between GCA and obesity in the Asian population and one study had even showed negative correlation [15,25].…”

Section: What Does the Current Study Add?mentioning

confidence: 99%

Gastric Cardia Cancer: How Much Is It from Fat?

Sinh

2012

Dig Dis Sci

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“…In contrast, the incidence of AEGJ is unchanged or only gradually increasing in the East [5][6][7], and its clinicopathological features have not yet been elucidated, especially in advanced, nonresectable tumors.…”

Section: Introductionmentioning

confidence: 96%

Comparison of advanced adenocarcinomas of esophagogastric junction and distal stomach in Japanese patients

et al. 2013

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Background There have been no reports on the incidence, characteristics, treatment outcomes, and prognosis of inoperably advanced or recurrent adenocarcinoma of the esophagogastric junction (AEGJ) in Japan. Methods We investigated the clinicopathological characteristics, treatment outcomes, and prognosis for 816 patients with esophagogastric junctional and gastric adenocarcinoma who received first-line chemotherapy between 2004 and 2009. Results Of 816 patients, 82 (10 %) had AEGJ. The patients with AEGJ had significantly more lung and lymph node metastasis, but less peritoneal metastasis, than those with gastric adenocarcinoma (GAC). The objective response rate to first-line chemotherapy was 23.3 % for patients with AEGJ and 22.6 % in patients with GAC (p = 0.90). The median survival was 13.0 months in AEGJ and 11.8 months in GAC (p = 0.445). In no patient was tumor site a significant prognostic factor (p = 0.472). In patients with AEGJ, ECOG PS C 2, presence of liver metastasis, and absence of lung metastasis were significantly associated with poor prognosis. Conclusions No significant differences were observed in treatment outcomes between advanced AEGJ and GAC. Therefore, the same chemotherapy regimen can be given as a treatment arm in future Japanese clinical trials to both patients with inoperably advanced or recurrent AEGJ and those with GAC.

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Cancer of the Gastric Cardia is Rising in Incidence in an Asian Population and is Associated with Adverse Outcome

Cited by 126 publications

References 39 publications

A Population-based Case-control Study on Risk Factors for Gastric Cardia Cancer in Rural Areas of Linzhou

A Population-based Case-control Study on Risk Factors for Gastric Cardia Cancer in Rural Areas of Linzhou

Gastric Cardia Cancer: How Much Is It from Fat?

Comparison of advanced adenocarcinomas of esophagogastric junction and distal stomach in Japanese patients

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