Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001

Madsen, Anders Rørbæk; Gundgaard, Maria Gry; Hoff, Camilla Molich; Maare, C.; Holmboe, Peter; Knap, M.M.; Thomsen, Lone L.; Buchwald, Christian von; Hansen, Hanne Sand; Bretlau, P; Grau, Cai

doi:10.1002/hed.20877

Cited by 71 publications

(57 citation statements)

References 12 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several larger series have reported preliminary descriptions of factors influencing survival, based on univariate comparisons. 2,6,7,16,20,21,24 In this study, we use multivariable analyses to identify factors independently associated with survival and recurrence in 72 patients undergoing temporal bone resection over 16 years at our 2 affiliated institutions. In all, 80% of cases were epithelial cancers, and 83% of patients underwent lateral temporal bone resection as the primary temporal bone procedure.…”

Section: Discussionmentioning

confidence: 99%

“…The literature on temporal bone resection includes important data that have been contributed by several large series. 2,6,16,20,21,23,24 However, most of these reports have been based on patients treated over the past half-century or longer. Treatment has changed substantially during this time.…”

Section: Discussionmentioning

confidence: 99%

“…Most cohorts have been limited to squamous cell histology, and comprehensive outcomes analyses have been limited. 2,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Further complicating analysis, there is no recognized American Joint Committee on Cancer (AJCC) or Union Internationale Contre le Cancer (UICC) staging system for tumors of the external auditory canal/temporal bone, with multiple systems having been proposed. 3,16,25,26 To date, the most widely used system is the University of Pittsburgh staging system, first described in 1990 by Arriaga and colleagues 25 and modified in 2000 by Moody et al 3 Other than Pittsburgh stage and surgical margin status, no other factors have been consistently demonstrated to be associated with outcome, and multivariable analyses of factors affecting outcome have not been reported.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

et al. 2011

View full text Add to dashboard Cite

Background. The purpose of this study was to identify factors predictive of outcome in patients undergoing temporal bone resection (TBR) for head and neck cancer.Methods. This was a retrospective study of 72 patients undergoing TBR. Factors associated with survival and recurrence were identified on multivariable regression. Results. Most tumors were epithelial (81%), commonly (69%) involving critical structures. Cervical metastases were uncommon (6%). Squamous cell carcinoma (SCC) of the external auditory canal carried a high rate of parotid invasion (25%) and parotid nodal metastases (43%).The 5-year rate of overall survival (OS) was 62%; disease-specific survival (DSS), 70%; recurrence-free survival (RFS), 46%. Factors independently associated with outcome on multivariable analysis were margin status and extratemporal spread of disease to the parotid, mandible, or regional nodes. Recurrence was common (72%) in cT3-4 tumors. Conclusions. Margin status and extratemporal disease spread are the strongest independent predictors of survival and recurrence. In SCC of the external auditory canal, high rates of parotid involvement support adjunctive parotidectomy. Risk of recurrence in T3-T4 tumors may support a role for adjuvant therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

et al. 2011

View full text Add to dashboard Cite

show abstract

“…1,2 Cancers of the external auditory canal/temporal bone comprise <0.2% of head and neck cancers. 3 The rarity and anatomic complexity of these tumors hampered the development of an en bloc ablative operation until 1954, when Parsons and Lewis 4 from Memorial Hospital in New York first described the technique of subtotal temporal bone resection.…”

mentioning

confidence: 99%

“…Most cohorts have been limited to squamous cell histology, and comprehensive outcomes analyses have been limited. 2,6–24 Further complicating analysis, there is no recognized American Joint Committee on Cancer (AJCC) or Union Internationale Contre le Cancer (UICC) staging system for tumors of the external auditory canal/temporal bone, with multiple systems having been proposed. 3,16,25,26 To date, the most widely used system is the University of Pittsburgh staging system, first described in 1990 by Arriaga and colleagues 25 and modified in 2000 by Moody et al 3 …”

mentioning

confidence: 99%

Predictors of survival and recurrence after temporal bone resection for cancer

et al. 2011

View full text Add to dashboard Cite

Background The purpose of this study was to identify factors predictive of outcome in patients undergoing temporal bone resection (TBR) for head and neck cancer. Methods This was a retrospective study of 72 patients undergoing TBR. Factors associated with survival and recurrence were identified on multivariable regression. Results Most tumors were epithelial (81%), commonly (69%) involving critical structures. Cervical metastases were uncommon (6%). Squamous cell carcinoma (SCC) of the external auditory canal carried a high rate of parotid invasion (25%) and parotid nodal metastases (43%). The 5-year rate of overall survival (OS) was 62%; disease-specific survival (DSS), 70%; recurrence-free survival (RFS), 46%. Factors independently associated with outcome on multivariable analysis were margin status and extratemporal spread of disease to the parotid, mandible, or regional nodes. Recurrence was common (72%) in cT3–4 tumors. Conclusions Margin status and extratemporal disease spread are the strongest independent predictors of survival and recurrence. In SCC of the external auditory canal, high rates of parotid involvement support adjunctive parotidectomy. Risk of recurrence in T3–T4 tumors may support a role for adjuvant therapy.

show abstract

A retrospective multicenter study of carbon‐ion radiotherapy for external auditory canal and middle ear carcinomas

et al. 2018

View full text Add to dashboard Cite

BackgroundWe conducted a retrospective multicenter study to assess the clinical outcomes of carbon‐ion radiotherapy (CIRT) for head and neck malignancies (Japan Carbon‐Ion Radiation Oncology Study Group [J‐CROS] study: 1402 HN). We aimed to evaluate the safety and efficacy of CIRT in patients with external auditory canal (EAC) and middle ear (ME) carcinomas.MethodsThirty‐one patients treated with CIRT at four Japanese institutions were analyzed. Fourteen patients (45.2%) had squamous cell carcinomas, 13 (41.9%) had adenoid cystic carcinomas, and four (12.9%) had other types. Nineteen (61.3%), six (19.4%), three (9.7%), and three (9.7%) patients had T4, T3, T2, and T1 disease, respectively. All patients had N0M0 status. The median radiation dose was 64 Gy (relative biological effectiveness) in 16 fractions. The median gross tumor volume was 33.3 mL.ResultsThe median follow‐up period was 18.4 months (range, 5.1‐85.6). The 1‐ and 3‐year local control and overall survival rates were 75.0% and 55.0% and 79.3% and 58.7%, respectively. Regarding grade 3 or higher toxicities, three patients (9.7%) had grade 3 dermatitis, one (3.2%) had grade 3 mucositis, and two (6.5%) had grade 3 central nervous necrosis (ie, radiation‐induced brain necrosis). No grade 4 or worse reactions were observed.ConclusionCIRT was effective for EAC and ME carcinomas.

show abstract

Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001

Abstract: This nationwide study confirmed that local failure is the main problem, and future improvements should focus on more aggressive local treatment.

Cited by 71 publications

References 12 publications

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

Predictors of survival and recurrence after temporal bone resection for cancer

A retrospective multicenter study of carbon‐ion radiotherapy for external auditory canal and middle ear carcinomas

Contact Info

Product

Resources

About