Cancer of the Esophagus

Puestow, Charles B.; Gillesby, William J.; Guynn, Vernon L.

doi:10.1001/archsurg.1955.01270110034006

Cited by 43 publications

(8 citation statements)

References 10 publications

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“…[3][4][5][6] The incidence of this tumor has, however, increased dramatically in recent years, to 27% to 50% of malignant esophageal tumors. [7][8][9] This increase cannot be explained exclusively by improvements in diagnostic methods or by changes in classification.…”

Section: Discussionmentioning

confidence: 99%

Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa

Noguchi

Takeno

Takahashi

et al. 2001

Journal of Gastroenterology

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Most esophageal malignancies are either squamous cell carcinomas or adenocarcinomas arising from Barrett's esophagus. We report a case of adenocarcinoma of the upper esophagus (cervical esophagus) that was derived from heterotopic gastric mucosa. In a 73-year-old man cervical esophagectomy was performed, followed by pharyngectomy, laryngectomy, and palliative dissection of lymph nodes on both sides of the neck, after an accurate diagnosis has been made by esophagography and endoscopy. The resected tumor was smoothly elevated (2.5 cm x 2.0 cm) and was microscopically identified as a well differentiated adenocarcinoma with invasion to the submucosa. The origin of the carcinoma was found to be a heterotopic gastric mucosa, by hematoxylin-eosin (H&E), immunohistochemical, and enzyme histochemical staining. To our knowledge, only 18 similar cases have been reported previously.

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Section: Discussionmentioning

confidence: 99%

Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa

Noguchi

Takeno

Takahashi

et al. 2001

Journal of Gastroenterology

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“…In several case series in the 1950s, the incidence of adenocarcinoma of the esophagus was reported to be 8% in the United Kingdom [17] and 10% in the United States [18]. These types of tumors were believed to arise from ectopic patches of gastric mucosa in the esophagus.…”

Section: Incidence Of Aeg In Western Countriesmentioning

confidence: 99%

Adenocarcinoma of the esophagogastric junction: incidence, characteristics, and treatment strategies

2010

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“…From 1926 to 1976, surgical series reported that ACE was uncommon, representing only 0.8-3.7% of all esophageal cancers [1][2][3][4]. In surgical series reported during the last 15 years from major referral institutions, 60-80% of the patients were diagnosed as having adenocarcinoma of the distal esophagus or EGJ compared with only 10-15% a decade earlier [5][6][7][8].…”

Section: Demographics Trends Of Adenocarcinoma Of the Esophagus And Egjmentioning

confidence: 99%

Epidemiology of esophageal adenocarcinoma

Pera

Manterola

Vidal

et al. 2005

Journal of Surgical Oncology

264

178

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The incidence of esophageal adenocarcinoma has risen rapidly over the past 25 years in the United States as well as in several Western European countries. This increase had been most dramatic among white males. The majority of these cancers arise from a background of premalignant Barrett esophagus. However, less than 10% of the patients with esophageal adenocarcinoma were known to have Barrett esophagus previously. It is uncertain which risk factors contribute to the increasing incidence of esophageal adenocarcinoma, although gastroesophageal reflux disease, cigarette smoking, and obesity have been implicated. Whereas infection with Helicobacter pylori and use of non-steroidal anti-inflammatory drugs are associated with reduced risk, low intakes of fruit, vegetables, and cereal fibers seem to increase the risk of esophageal adenocarcinoma. Presently there is no evidence that strongly supports any specific strategy to screen a subgroup of the population at risk for Barrett esophagus and adenocarcinoma of the esophagus.

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Cancer of the Esophagus

Cited by 43 publications

References 10 publications

Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa

Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa

Adenocarcinoma of the esophagogastric junction: incidence, characteristics, and treatment strategies

Epidemiology of esophageal adenocarcinoma

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