Cancer of the cervix uteri: 2021 update

Bhatla, Neerja; Aoki, Daisuke; Sharma, Daya Nand; Sankaranarayanan, Rengaswamy

doi:10.1002/ijgo.13865

Cited by 183 publications

(125 citation statements)

References 150 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…Our results also indicated that higher NOD1 or NOD2 expression was not associated with advanced tumor stages. As we know, advanced stage cervical cancer means worse OS; poor differentiation is not a definitely middle/high-risk factor for prognosis in patients with CSCC [ 38 ]. From the above results, we can predict that CSCC patients in the same stage with the higher NOD1 expression have worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer

Zhang

Yuan

et al. 2022

BMC Med

View full text Add to dashboard Cite

Background Metastatic cervical squamous cell carcinoma (CSCC) has poor prognosis and is recalcitrant to the current treatment strategies, which warrants the necessity to identify novel prognostic markers and therapeutic targets. Given that CSCC is a virus-induced malignancy, we hypothesized that the pattern recognition receptors (PRRs) involved in the innate immune response likely play a critical role in tumor development. Methods A bioinformatics analysis, qPCR, IHC, immunofluorescence, and WB were performed to determine the expression of NOD1/NOD2. The biological characteristics of overexpression NOD1 or NOD2 CSCC cells were compared to parental cells: proliferation, migration/invasion and cytokines secretion were examined in vitro through CCK8/colony formation/cell cycle profiling/cell counting, wound healing/transwell, and ELISA assays, respectively. The proliferative and metastatic capacity of overexpression NOD1 or NOD2 CSCC cells were also evaluated in vivo. FCM, mRNA and protein arrays, ELISA, and WB were used to identify the mechanisms involved, while novel pharmacological treatment were evaluated in vitro and in vivo. Quantitative variables between two groups were compared by Student’s t test (normal distribution) or Mann-Whitney U test (non-normal distribution), and one-way or two-way ANOVA was used for comparing multiple groups. Pearson χ2 test or Fisher’s exact test was used to compare qualitative variables. Survival curves were plotted by the Kaplan-Meier method and compared by the log-rank test. P values of < 0.05 were considered statistically significant. Results NOD1 was highly expressed in CSCC with lymph-vascular space invasion (LVSI, P < 0.01) and lymph node metastasis (LM, P < 0.01) and related to worse overall survival (OS, P = 0.016). In vitro and in vivo functional assays revealed that the upregulation of NOD1 or NOD2 in CSCC cells promoted proliferation, invasion, and migration. Mechanistically, NOD1 and NOD2 exerted their oncogenic effects by activating NF-κb and ERK signaling pathways and enhancing IL-8 secretion. Inhibition of the IL-8 receptor partially abrogated the effects of NOD1/2 on CSCC cells. Conclusions NOD1/2-NF-κb/ERK and IL-8 axis may be involved in the progression of CSCC; the NOD1 significantly enhanced the progression of proliferation and metastasis, which leads to a poor prognosis. Anti-IL-8 was identified as a potential therapeutic target for patients with NOD1high tumor.

show abstract

Section: Discussionmentioning

confidence: 99%

Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer

Zhang

Yuan

et al. 2022

BMC Med

View full text Add to dashboard Cite

show abstract

“…Other available detection methods include visual inspection, and detection of HPV nucleic acids and biomarkers predictive of cervical cancer. In the 2020s, with the advancement of technology, artificial intelligence (AI) has been a popular module incorporated for detecting and reading cervical cytology samples [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. The use of AI techniques can alleviate the scarcity of professional resources and the heavy workloads, and at the same time increase the accuracy and specificity of diagnosis.…”

Section: Detection Of Premalignancy and Malignancy Of The Uterine Cervixmentioning

confidence: 99%

“…The system was established in 1958 to recognise the recurrence rate and patients’ outcomes with regard to the degree of tumour spread from initial sites. In response to the increased understanding of cancer, the system was then consistently revised and updated in 1988, 2009, 2014, and 2018 [ 25 , 87 ]. This clinical staging system has been predominantly used in clinical practice and reporting worldwide.…”

Section: Staging System For Cervical Intraepithelial Neoplasia and Ca...mentioning

confidence: 99%

“…Misestimating the primary stage will affect the judgement of prognostic factors, and it is extremely important to have a precise judgement on cancer staging. Hence, in the latest 2018 FIGO staging system, additional imaging and pathological findings are taken into consideration when assigning the cancer stage [ 25 ]. Stage IB was included in the latest version.…”

Section: Staging System For Cervical Intraepithelial Neoplasia and Ca...mentioning

confidence: 99%

See 1 more Smart Citation

Review of the Standard and Advanced Screening, Staging Systems and Treatment Modalities for Cervical Cancer

Boon

Luk

Xiao

et al. 2022

Cancers

View full text Add to dashboard Cite

Cancer arising from the uterine cervix is the fourth most common cause of cancer death among women worldwide. Almost 90% of cervical cancer mortality has occurred in low- and middle-income countries. One of the major aetiologies contributing to cervical cancer is the persistent infection by the cancer-causing types of the human papillomavirus. The disease is preventable if the premalignant lesion is detected early and managed effectively. In this review, we outlined the standard guidelines that have been introduced and implemented worldwide for decades, including the cytology, the HPV detection and genotyping, and the immunostaining of surrogate markers. In addition, the staging system used to classify the premalignancy and malignancy of the uterine cervix, as well as the safety and efficacy of the various treatment modalities in clinical trials for cervical cancers, are also discussed. In this millennial world, the advancements in computer-aided technology, including robotic modules and artificial intelligence (AI), are also incorporated into the screening, diagnostic, and treatment platforms. These innovations reduce the dependence on specialists and technologists, as well as the work burden and time incurred for sample processing. However, concerns over the practicality of these advancements remain, due to the high cost, lack of flexibility, and the judgment of a trained professional that is currently not replaceable by a machine.

show abstract

“…Most patients with advanced-stage tumors receive radiotherapy or chemotherapy after biopsy. Surgical therapy may be performed at an early stage for small lesions [ 3 ]. Thus, it is difficult to obtain sufficient specimens for examination and research purposes.…”

Section: Introductionmentioning

confidence: 99%

Validation of a Patient-Derived Xenograft Model for Cervical Cancer Based on Genomic and Phenotypic Characterization

Miyamoto

Tanaka

Hirosuna

et al. 2022

Cancers

View full text Add to dashboard Cite

Patient-derived xenograft (PDX) models are useful tools for preclinical drug evaluation, biomarker identification, and personalized medicine strategies, and can be developed by the heterotopic or orthotopic grafting of surgically resected tumors into immunodeficient mice. We report the PDX models of cervical cancer and demonstrate the similarities among original and different generations of PDX tumors. Fresh tumor tissues collected from 22 patients with primary cervical cancer were engrafted subcutaneously into NOD.CB17-PrkdcSCID/J mice. Histological and immunohistochemical analyses were performed to compare primary and different generations of PDX tumors. DNA and RNA sequencing were performed to verify the similarity between the genetic profiles of primary and PDX tumors. Total RNA in extracellular vesicles (EVs) released from primary and PDX tumors was also quantified to evaluate gene expression. The total tumor engraftment rate was 50%. Histologically, no major differences were observed between the original and PDX tumors. Most of the gene mutations and expression patterns related to carcinogenesis and infiltration were similar between the primary tumor and xenograft. Most genes associated with carcinogenesis and infiltration showed similar expression levels in the primary tumor and xenograft EVs. Therefore, compared with primary tumors, PDX models could be potentially more useful for translational research.

show abstract

Cancer of the cervix uteri: 2021 update

Cited by 183 publications

References 150 publications

Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer

Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer

Review of the Standard and Advanced Screening, Staging Systems and Treatment Modalities for Cervical Cancer

Validation of a Patient-Derived Xenograft Model for Cervical Cancer Based on Genomic and Phenotypic Characterization

Contact Info

Product

Resources

About