Cancer nanotechnology: application of nanotechnology in cancer therapy

Misra, Ranjita; Acharya, Sarbari; Sahoo, Sanjeeb K.

doi:10.1016/j.drudis.2010.08.006

Cited by 593 publications

(350 citation statements)

References 65 publications

Supporting

Mentioning

326

Contrasting

Unclassified

Order By: Relevance

“…[16,33] The rationale of nanoparticle engineering is aimed to improve the therapeutic advantages of cancer nanomedicines, which include: (i) carrying and delivering high amount of therapeutic payloads ranging from small chemotherapy agents to larger biologics without leaking before it reaches the desired tissues or cells; (ii) reducing the interaction with the mononuclear phagocytic system (MPS), thereby prolonging the circulation time in the bloodstream; (iii) increasing the accumulation of nanoparticles in the active tumor sites in order to reduce the unwanted off-target side effects; (iv) attaching multiple targeting ligands to the surface of nanoparticles for high affinity and specificity for tumor tissue or cancer cell targeting; and (v) facilitating the intracellular drug delivery by overcoming the different biological barriers and by-pass the drug resistance mechanism.…”

Section: Cancer Nanomedicines From the Nano-engineering Perspectivementioning

confidence: 99%

“…This includes, solid lipid nanoparticles, liposomes, polymeric micelles, hydrogels, dendrimers, polymersomes, inorganic nanoparticles (e.g., iron oxide, quantum dots, gold, silica and silicon particles), among many others (Figure 2). [16,34] However, in some cases, the combination of different types of nanoparticles have also been used for nanomedicine development. In most cases, these systems are constructed with desirable biological properties, such as biocompatibility and biodegradability, for the intended biological applications.…”

Section: Cancer Nanomedicines From the Nano-engineering Perspectivementioning

confidence: 99%

“…Anti-cancer nanomedicines are rapidly emerging as a promising approach and offers the possibilities to the clinicians to overcome the limitations of current cancer therapy. [14][15][16][17] In this direction, an array of nanomedicines has been synthesized, engineered with different physiochemical properties, such as size, shape and surface chemistry, and formulated with a large variety of anti-cancer therapeutics, including surface modifications with, e.g., polyethylene glycol (PEG) or other coatings, in order to extend the circulation time of the nanomedicines in bloodstream. [18][19][20] Various targeting moieties, such as antibodies, peptides, sugars and proteins, have also been attached to nanomedicines in different ways to further facilitate their selective accumulation within the tumors.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

Balasubramanian

Liu

Hirvonen

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

Explosive growth of nanomedicines continues to significantly impact the therapeutic strategies for effective cancer treatment. Despite the significant progress in the development of advanced nanomedicines, successful clinical translation remains challenging. As cancer nanomedicine is a multidisciplinary field, the fundamental problem is that the knowledge gaps stem from different vantage points in the understanding of cancer nanomedicines. The complexities and heterogenecity of both nanomedicines and cancer are further demanding the integration of highly diverse expertise to develop clinically translatable cancer nanomedicines. This progress report aims to discuss the current understanding of cancer nanomedicines between different research areas in terms of nanoparticle engineering, formulation, tumor patho-physiology and clinical medicine, as well as to identify the knowledge gaps lying at the interface between the different fields of research in nanomedicine. Here we also highlight for the necessity to harmonize the multidisciplinary effort in the research of nanomedicines in order to bridge the knowledge and to advance the full understanding in cancer nanomedicines. A paradigm shift is needed in the strategic development of disease specific nanomedicines in order to foster the successful translation into clinic of future cancer nanomedicines.

show abstract

Section: Cancer Nanomedicines From the Nano-engineering Perspectivementioning

confidence: 99%

Section: Cancer Nanomedicines From the Nano-engineering Perspectivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

Balasubramanian

Liu

Hirvonen

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…By improving site specificity, nanoscale technology offers the possibility of exceptional improvements in earlystage diagnosis and therapeutics, and also the potential for circumventing multi-drug resistance (MDR) [7,8].…”

Section: Introductionmentioning

confidence: 99%

The potential legacy of cancer nanotechnology: cellular selection

Patra

Turner

2014

Trends in Biotechnology

View full text Add to dashboard Cite

Overexpression of oncogenes or loss of tumour suppressors can transform a normal cell to a cancerous one, resulting in uncontrolled regulation of intracellular signaling pathways and immunity to stresses, which both pose therapeutic challenges.Conventional approaches to cancer therapy, although they are effective at killing cancer cells, may still fail due to inadequate biodistribution and unwanted side effects.Nanotechnology-based approaches provide a promising alternative, with the possibility of targeting cells at an early stage, during their transformation into cancer cells. This review considers techniques that specifically target those molecular changes, which begin in only a very small percentage of normal cells as they undergo transformation. These techniques are crucial for 'early-stage' diagnosis and therapy.3

show abstract

“…In recent years, carbon nanotubes have received a growing interest in several fields as materials industry, electronics, medicine and also in analytical applications. [2][3][4][5][6][7] Carbon nanotubes can be described as a kind of graphite structure which is based on benzene-type hexagonal rings of carbon atoms, rolled up in a nanoscale tube (diameter ranging from a few tenths to tens of nanometers). This nanomaterial can be defined as a single-wall carbon nanotube (SWCNT) and when additional graphene tubes are present around the core of a SWCNT, it is defined as a multi-wall carbon nanotube (MWCNT).…”

Section: Introductionmentioning

confidence: 99%

Determination of metal impurities in carbon nanotubes by direct solid sampling electrothermal atomic absorption spectrometry

Mello¹,

Rodrigues²,

Nunes³

et al. 2011

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

soluções aquosas e massa máxima de amostra. Para comparação dos resultados as amostras foram analisadas por espectrometria de massa com plasma indutivamente acoplado (ICP-MS) e espectrometria de emissão óptica com plasma indutivamente acoplado (ICP OES) após decomposição por via úmida em sistema de alta pressão assistida por micro-ondas e também por combustão iniciada por micro-ondas. Não foram observadas diferenças significativas entre os resultados obtidos pelo método proposto e pelas outras técnicas. A exatidão também foi avaliada por comparação com resultados de análise por ativação neutrônica (NAA). A calibração foi possível com soluções de referência aquosas. Os sinais de fundo foram sempre inferiores a 0,02 (altura de pico) e o uso de modificador químico não foi necessário. O método proposto possibilitou a determinação de todos os analitos, com menores limites de detecção quando comparados com as outras técnicas.Metal impurities (Al, Cd, Co, Cr, Cu, Mg, Mn and Pb) were determined in carbon nanotubes (CNTs) by direct solid sampling electrothermal atomic absorption spectrometry (DSS-ET AAS, deuterium lamp background corrector). Parameters as pyrolysis and atomization temperatures, use of Pd as chemical modifier, feasibility of calibration using aqueous standard solutions and maximum sample mass were investigated. Results obtained by the proposed method were compared with those obtained by neutron activation analysis (NAA) and also by inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP OES) after high-pressure microwave assisted wet digestion and microwave-induced combustion methods. No significant differences were observed between the results obtained by DSS-ET AAS, ICP-MS and ICP OES after both digestion methods and also by NAA. Calibration was performed using aqueous standards. Background signals were always lower than 0.02 (peak height) and no chemical modifier was used. The proposed method allowed the determination of all elements in CNTs with lower limits of detection in comparison with other techniques.Keywords: carbon nanotubes, metal impurities, solid sampling, electrothermal atomic absorption spectrometry IntroductionSince the advent of nanotechnology the development of new materials with a wide range of special properties has been performed for very different applications in almost all technological fields. With the discovery of carbon nanotubes (CNTs) by Iijima, 1 this new class of nanomaterials provided unique chemical, mechanical and electronic properties. In recent years, carbon nanotubes have received a growing interest in several fields as materials industry, electronics, medicine and also in analytical applications. [2][3][4][5][6][7] Carbon nanotubes can be described as a kind of graphite structure which is based on benzene-type hexagonal rings of carbon atoms, rolled up in a nanoscale tube (diameter ranging from a few tenths to tens of nanometers). This nanomaterial can be defined as a single-wall carbon nanotube (SWCNT) ...

show abstract

Cancer nanotechnology: application of nanotechnology in cancer therapy

Cited by 593 publications

References 65 publications

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

The potential legacy of cancer nanotechnology: cellular selection

Determination of metal impurities in carbon nanotubes by direct solid sampling electrothermal atomic absorption spectrometry

Contact Info

Product

Resources

About