Cancer mortality trends between 1988 and 2009 in the metropolitan area of Naples and Caserta, Southern Italy

Crispo, Anna; Barba, Maddalena; Malvezzi, Matteo; Arpino, Grazia; Grimaldi, Maria; Rosso, Tiziana; Esposito, Emanuela; Sergi, Domenico; Ciliberto, Gennaro; Giordano, Antonio; Montella, Maurizio

doi:10.4161/cbt.26425

Cited by 16 publications

(15 citation statements)

References 30 publications

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“…Indeed, toxic agent accumulation has been suggested to associate with a significant increase in cancer development and mortality in these areas (Altavista et al, 2004;Comba et al, 2006Comba et al, , 2014Crispo et al, 2013;Di Lorenzo, Federico, De Placido, & Buonerba, 2015;Fazzo et al, 2011;Martuzzi et al, 2009;Petrosino et al, 2018;Zona et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, an important biomonitoring study funded by the Italian National Institute of Health, the “SEBIOREC Project,” evaluated the levels of environmental contaminants in blood and human milk in more than 850 healthy donors from Campania areas in the years 2008 and 2009 and suggested the possible need of interventions aimed to improve health conditions in some municipalities (De Felip et al, ). Indeed, toxic agent accumulation has been suggested to associate with a significant increase in cancer development and mortality in these areas (Altavista et al, ; Comba et al, ; Crispo et al, ; Di Lorenzo, Federico, De Placido, & Buonerba, ; Fazzo et al, ; Martuzzi et al, ; Petrosino et al, ; Zona et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Forte

Indovina

Costa

et al. 2019

Journal Cellular Physiology

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In Italy, in the eastern area of the Campania region, the illegal dumping and burning of waste have been documented, which could potentially affect the local population's health. In particular, toxic waste exposure has been suggested to associate with increased cancer development/mortality in these areas, although a causal link has not yet been established. In this pilot study, we evaluated blood levels of toxic heavy metals and persistent organic pollutants (POPs) in 95 patients with different cancer types residing in this area and in 27 healthy individuals. While we did not find any significant correlation between the blood levels of POPs and the provenance of the patients, we did observe high blood concentrations of heavy metals in some municipalities, including Giugliano, where many illegal waste disposal sites have previously been documented. Our results showed that patients with different cancer types from Giugliano had higher blood levels of heavy metals than healthy controls. Despite the obvious limitations of this exploratory study, our preliminary observations encourage further research assessing the possible association between exposure to hazardous waste, increased blood metals, and increased risk of cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Forte

Indovina

Costa

et al. 2019

Journal Cellular Physiology

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“…However, in the Campania Region, this decrease has been just 14% [ 51 ]. Further, in the provinces of Napoli and Caserta ( Figure 1 ), SMR have shown an increase by as much as 20% for some tumour types [ 52 ]. Similar results emerged from the “SENTIERI” study, analyzing SMR for the main causes of death (mainly cancers and cardiovascular diseases), published by the national Higher Institute of Health [ 51 ].…”

Section: Methodsmentioning

confidence: 99%

“…The increase in SMR for tumours of the study-area population has been associated, directly or indirectly, with exposure to chemical, physical or biological pollutants from repeated illegal dumping of waste in superficial or underground landfills. Although a causal relationship between environmental exposure and health effects has not yet been convincingly demonstrated, a possible association has been discussed or suggested by a number of publications [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]; see details in the supplementary material .…”

Section: Methodsmentioning

confidence: 99%

An Integrated Approach for the Environmental Characterization of a Wide Potentially Contaminated Area in Southern Italy

Ducci

Albanese

Boccia

et al. 2017

IJERPH

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This paper deals with the environmental characterization of a large and densely populated area, with a poor reputation for contamination, considering the contribution of environmental features (air, soil, soil hydraulic and groundwater) and the potential effects on human health. The use of Geographic Information System (GIS) has made possible a georeferenced inventory and, by overlaying environmental information, an operational synthesis of comprehensive environmental conditions. The cumulative effects on environmental features were evaluated, taking into account superposition effects, by means of the Spatial MultiCriteria Decision Analysis (S-MCDA). The application of the S-MCDA for converging the combination of heterogeneous factors, related to soil, land and water, deeply studied by heterogeneous groups of experts, constitutes the novelty of the paper. The results confirmed an overall higher potential of exposure to contaminants in the environment and higher mortality rates in the study area for some tumours, but hospital admissions for tumours were generally similar to the regional trend. Besides, mortality data may be strictly dependent on the poor socioeconomic conditions, quality of therapy and a lack of welfare in the area relative to the rest of Italy. Finally, as regards the possible relationship between presence of contaminants in the environment and health conditions of the population no definite conclusions can be drawn, although the present study encourages the use of the new proposed methods, that increase the possibilities for studying the combined effect of more environmental factors.

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“…However, in the Campania Region, this decrease has been just 14% [51]. Further, in the provinces of Napoli and Caserta (Figure 1), more detailed provincial mortality data have shown an increase in SMR by as much as 20% for some tumours [52]. Similar results emerged from the "SENTIERI" study, analyzing SMR for the main causes of death (mainly cancers and cardiovascular diseases), published by the national Higher Institute of Health [51].…”

Section: Human Exposure and Health Assessmentmentioning

confidence: 99%

An Integrated Approach for the Environmental Characterization of a Wide Area Potentially Contaminated (Southern Italy)

Ducci¹,

Albanese²,

Boccia³

et al. 2017

Preprint

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This paper deals with the environmental characterization of a large and densely populated area, with a poor reputation for contamination, considering the contribution of environmental features (air, soil, soil hydraulic and groundwater) and the potential effects on human health. The use of Geographic Information System (GIS) has made possible a georeferenced inventory and, by overlaying environmental information, an operational synthesis of comprehensive environmental conditions. The cumulative effects on environmental features were evaluated, taking into account superposition effects, by means of the spatial multicriteria decision analysis (S-MCDA). The application of the S-MCDA for converging the combination of heterogeneous factors, related to soil, land and water, deeply studied by heterogeneous groups of experts, constitutes the novelty of the paper. The results confirmed an overall higher potential of exposure to contaminants in the environment and higher mortality rates in the study area for some tumours, but hospital admissions for tumours were generally similar to the regional trend. Besides, mortality data may be strictly dependent on the poor socioeconomic conditions, quality of therapy and a lack of welfare in the area relative to the rest of Italy. Finally, as regards the possible relationship between presence of contaminants in the environment and health conditions of the population no definite conclusions can be drawn, although the present study encourages the use of the new proposed methods, that increase the possibilities for studying the combined effect of more environmental factors.

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Cancer mortality trends between 1988 and 2009 in the metropolitan area of Naples and Caserta, Southern Italy

Cited by 16 publications

References 30 publications

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

An Integrated Approach for the Environmental Characterization of a Wide Potentially Contaminated Area in Southern Italy

An Integrated Approach for the Environmental Characterization of a Wide Area Potentially Contaminated (Southern Italy)

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