Background Efforts have been made for 25 years to develop asbestos risk assessments that provide valid information about workplace and community cancer risks. Mathematical models have been applied to a group of workplace epidemiology studies to describe the relationships between exposure and risk. EPA's most recent proposed method was presented at a public meeting in July 2008. Methods Risk assessments prepared by USEPA, OSHA, and NIOSH since 1972 were reviewed, along with related literature. Results and Conclusions None of the efforts to use statistical models to characterize relative cancer potencies for asbestos fiber types and sizes have been able to overcome limitations of the exposure data. Resulting uncertainties have been so great that these estimates should not be used to drive occupational and environmental health policy. The EPA has now rejected and discontinued work on its proposed methods for estimating potency factors. Future efforts will require new methods and more precise and reliable exposure assessments. However, while there may be genuine need for such work, a more pressing priority with regard to the six regulated forms of asbestos and other asbestiform fibers is to ban their production and use. Am. J. Ind. Med. 52:850-858, 2009 . The relative potencies of asbestos fiber types, given that all types are known to cause both lung cancer and mesothelioma. . The health effects of various non-asbestiform fibers, cleavage products and unregulated fibers with asbestiform habits.ß 2009 Wiley-Liss,Inc. . The roles of fiber dimension (length, diameter, and aspect ratio), surface properties, chemical composition, biopersistence, and other physicochemical characteristics in determining toxicity. . The need for standardization of sampling and analytical methods to improve specificity, precision, and reliability in the measurement of biologically meaningful fiber parameters.For more than 25 years efforts have been made to develop asbestos risk assessment methods that provide reasonably valid and reliable information about workplace and community cancer risks. Increasingly sophisticated mathematical techniques have been used to fit data from workplace epidemiology studies into statistical models to shed light on the relationships between asbestos fiber types and dimensions and the risk of lung cancer and mesothelioma. However, none of these efforts have been able to overcome a fundamental hurdle recognized as early as 1972 by the National Institute for Occupational Safety and Health (NIOSH): ''The environmental samples were expressly collected in many cases for control purposes rather than for research and, as a result, meaningful evaluations cannot be made'' [NIOSH, 1972].EPA's most recent asbestos cancer risk assessment proposal [Brattin, 2008] has now been formally rejected by the agency following a public meeting of its Scientific Advisory Board Asbestos Committee July 21-22, 200821-22, [Johnson, 2008. The dismissal of this proposal has demonstrated that mathematical brute force cannot turn a meta-a...