Cancer mortality among relatives of children with soft-tissue sarcoma: A national survey in Italy

Pastore, Guido; Mosso, Maria Luisa; Carli, Modesto; P, Ghibaudo; Bernardi, Bruno; Mancini, Antonia; Pianca, C.; Grotto, Paolo; Terracini, Benedetto

doi:10.1016/0304-3835(87)90141-8

Cited by 13 publications

(5 citation statements)

References 10 publications

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“…[7][8][9][10] The earlier studies involved 177 children with soft-tissue sarcomas (1.7 times the average risk of cancer was found in mothers) 7 ; 159 children with soft-tissue sarcomas (1.3 times the average risk of cancer was found in first-degree relatives) 9 ; 47 cases of bilateral retinoblastoma (1.3 times the average risk of cancer was found in first-degree relatives) 8 ; and 326 children with a variety of types of cancer (1.7 times the average risk of cancer was found in mothers). 10 Our findings are more in line with hospital-based studies in Italy, 22 the United States, 13 and France, 23 which reported no overall increased risk *Parents of 51 children with hepatic tumors and 77 children with other and unspecified malignant neoplasms are not shown in this table because these groups were too small to yield meaningful results. Expected numbers of cancers are from national incidence rates adjusted for sex, age, and date of diagnosis.…”

Section: Discussionsupporting

confidence: 85%

Cancer in the Parents of Children with Cancer

Olsen

Boice²,

Seersholm

et al. 1995

N Engl J Med

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Section: Discussionsupporting

confidence: 85%

Cancer in the Parents of Children with Cancer

Olsen

Boice²,

Seersholm

et al. 1995

N Engl J Med

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“…However, only one of the excess cancer sites (brain) has been prominent in the constellation of neoplasms that comprise the Li-Fraumeni cancer family syndrome featuring sarcomas of the softtissues or bone, breast cancer, brain tumors, leukemia, and adrenocortical tumors (14)(15)(16)(17)47). Breast cancer and leukemia, often noted in the family members with this syndrome (15,17,48,49), did not occur more often than expected among the relatives of the Kansas soft-tissue sarcoma cases.…”

Section: Medical Historymentioning

confidence: 98%

A Case-Control Study of Soft-Tissue Sarcoma

Zahm

Blair

Holmes

et al. 1989

American Journal of Epidemiology

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The roles of nonagricultural occupations, tobacco use, beverage consumption, medical history, and other factors in the development of soft-tissue sarcoma were examined in a population-based case-control study in Kansas. Based on 133 cases diagnosed between 1976-1982 and 948 controls, there were significant excesses associated with use of the drug chloramphenicol (odds ratio (OR) = 5.4, 95% confidence interval (Cl) 1.2-23.9) and chewing tobacco or snuff (OR = 1.8, 95% Cl 1.1-2.9). The risk associated with smokeless tobacco varied with the location of the tumors; greater risks were observed for tumors of the upper gastrointestinal tract (OR = 3.3), the lung, pleura, and thorax (OR = 3.1), and the head, neck, and face region (OR = 2.4) than other regions of the body (OR = 1.4). A nonsignificant excess was seen with the use of cholesterol-lowering drugs, such as clofibrate (OR = 1.7). Four cases reported histories of prior radiation treatment to the same area of their bodies as their tumors. Soft-tissue sarcoma was also associated with employment in woodworking occupations (OR = 1.7, 95% Cl 0.9-3.2) and risk increased with increasing duration of employment. Persons with first-degree blood relatives with a history of Hodgkin's disease, lymphoma, or cancers of the pancreas, prostate, brain, or skin were at increased risk. Many of the associations observed in this study, notably the risk of soft-tissue sarcoma with smokeless tobacco and medications such as chloramphenicol, deserve further evaluation.

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“…In previous studies of parents of children with cancer, mortality has been reported only very occasionally (Pastore et al, 1987;Johansen and Olsen, 1997;Mosso et al, 1999;Pang et al, 2003), whereas cancer incidence has been investigated in a more substantial number of studies (Birch et al, 1984;Li et al, 1988;Gustafsson et al, 1995;Olsen et al, 1995Olsen et al, , 1999Brunetti et al, 2003;Pang et al, 2003). While studies of the latter type involve larger numbers of cancer cases, and therefore are more powerful to detect familial aggregations of cancer, mortality studies provide information on a wider spectrum of health effects.…”

mentioning

confidence: 93%

Mortality from cancer and other causes in parents of children with cancer: a population-based study in Piedmont, Italy

Zuccolo

Pastore²,

Pearce³

et al. 2007

European Journal of Cancer Prevention

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This population-based study (the largest on this issue conducted in Southern Europe) has examined mortality among the parents of 2622 children diagnosed with cancer in Piedmont during 1967-1994. Parents were followed up from the date of the index child's birth until the end of 2000, yielding a total of 118 090.7 person-years of observation. Standardized mortality ratios (SMRs) were estimated using mortality rates for the whole population of Piedmont as the reference. Among mothers, total mortality was similar to that expected [SMR 1.02, 95% confidence interval (CI) 0.85-1.23, 117 cases]. A reduced risk of mortality was seen in fathers (SMR 0.91, 95% CI 0.81-1.02, 293 cases); this was largely due to causes other than cancer and the reduction in risk disappeared after the index child's death (SMR 0.98, 95% CI 0.84-1.15, 168 cases). Deaths from cancers of the lymphohaematopoietic system were in excess among mothers (SMR=2.13, 95% CI 1.02-3.92, 10 cases) and breast cancer deaths were in excess specifically among mothers of leukaemic children (SMR 2.32, 95% CI 1.16-4.14, 11 cases). Three mothers dying with breast cancer had index children who had been diagnosed with a bone sarcoma. Parental cancer of the respiratory tract was significantly associated with both tumours of the central nervous system and Hodgkin's lymphoma in the index child. The excess risks identified here may be due to genetic factors or due to parental psychological stress consequent to cancer in a child that may lead to increased mortality either through the direct effects of stress or through consequent changes in lifestyle.

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Cancer mortality among relatives of children with soft-tissue sarcoma: A national survey in Italy

Cited by 13 publications

References 10 publications

Cancer in the Parents of Children with Cancer

Cancer in the Parents of Children with Cancer

A Case-Control Study of Soft-Tissue Sarcoma

Mortality from cancer and other causes in parents of children with cancer: a population-based study in Piedmont, Italy

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