Cancer Invasion and Metastases

Liotta, Lance A.; Kohn, Elise C.

doi:10.1001/jama.1990.03440080101032

Cited by 108 publications

(26 citation statements)

References 20 publications

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“…Metastasis of renal cell carcinoma cells depends on some factors that are only partly understood: proteolysis, cellular attachment, angiogenesis, migration through the barrier into secondary sites, and colonization and proliferation in distant organs [1]. Proteolytic degradation of the basement membrane is a fundamental aspect of cancer development and a key event in the regulation of tumor proliferation and metastasis [2].…”

Section: Introductionmentioning

confidence: 99%

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma

Qiao

et al. 2013

World J Surg Onc

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BackgroundMatrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis and are inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs). {AU Query: Please verify that corrections made to previous sentence did not alter intended meaning}. In this study, we examined the expression of MMP-2, MMP-9, membrane-type 1 (MT1)-MMP, TIMP-1, and TIMP-2 in renal tissue samples of renal cell cancer and examined the correlation between their expression and clinicopathological parameters.MethodsRenal tissue samples from 76 patients with renal cell carcinoma were available for this study. To determine the expression of MMP-2, MMP-9, MT1-MMP, TIMP-1, and TIMP-2, semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was carried out on tumor and normal tissues.ResultsMean MMP-2, MMP-9, MT1-MMP, TIMP-1, and TIMP-2 mRNA expression in the renal cell carcinomas was significantly higher than in the normal renal tissue (P <0.05). The RT-PCR data of MMP-2, MMP-9, MT1-MMP, TIMP-1, and TIMP-2 did not show any significant correlation with tumor type or pathologic grade of renal cell carcinoma. MMP-2, MMP-9 and MT1-MMP mRNA expression increased significantly with the TNM stage of the tumor.ConclusionsMean MMP-2, MMP-9, MT1-MMP, TIMP-1, and TIMP-2 mRNA expression in the renal cell carcinomas was significantly higher than in the normal renal tissue.

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Section: Introductionmentioning

confidence: 99%

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma

Qiao

et al. 2013

World J Surg Onc

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“…Metastasis of gastric cancer cells depends on some only partly understood factors: angiogenesis, cellular attachment, proteolysis, migration through the barrier into secondary sites, and, of course, colonization and proliferation in distant organs. 1 One important step in tumor invasion is the penetration of the basement membrane. 2 The basement membrane is a strong barrier to the movement of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer

et al. 2007

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“…Invasion and metastasis takes place in multi-step processes that require the coordinated expression of a number of proteins by the tumor cells resulting in altered cell-cell, cell-substratum adhesion, and increased motility (Liotta and Kohn 1990;Timar et al 2001Timar et al , 2002. During the metastasis process, tumor cells need to attach to other cells and matrix proteins, which are subsequently degraded for invasion by speciWc proteases including lysosomal cathepsins.…”

Section: Introductionmentioning

confidence: 99%

A role of LIM kinase 1/cofilin pathway in regulating endocytic trafficking of EGF receptor in human breast cancer cells

Nishimura

Yoshioka

Bernard

et al. 2006

Histochem Cell Biol

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We have previously shown that overexpression of LIM kinase1 (LIMK1) resulted in a marked retardation of the internalization of the receptor-mediated endocytic tracer, Texas red-labeled epidermal growth factor (EGF) in low-invasive human breast cancer cell MCF-7. We thereby postulate that LIMK1 signaling plays an important role in the regulation of ligand-induced endocytosis of EGF receptor (EGFR) in tumor cells by reorganizing and influencing actin-filament dynamics. In the present study, we further assessed the effect of wild-type LIMK1, a kinase-deficient dominant negative mutant of LIMK1 (DN-LIMK1) and an active, unphosphorylatable cofilin mutant (S3A cofilin) on internalization of EGF-EGFR in MDA-MB-231, a highly invasive human breast cancer cell line. We demonstrate here that a marked delay in the receptor-mediated internalization of Texas red-labeled EGF was observed in the wild-type LIMK1 transfectants, and that most of the internalized EGF staining were accumulated within transferrin receptor-positive early endosomes even after 30 min internalization. In contrast, the expression of dominant-negative LIMK1 mutant rescued the efficient endocytosis of Texas red-EGF, and large amounts of Texas red-EGF staining already reached LIMPII-positive late endosomes/lysosomal vacuoles after 15 min internalization. We further analyzed the effect of S3A cofilin mutant on EGFR trafficking, and found an efficient delivery of Texas red-EGF into late endosomes/lysosomes at 15-30 min after internalization. Taken together, our novel findings presented in this paper implicate that LIMK1 signaling indeed plays a pivotal role in the regulation of EGFR trafficking through the endocytic pathway in invasive tumor cells.

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Cancer Invasion and Metastases

Cited by 108 publications

References 20 publications

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma

Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer

A role of LIM kinase 1/cofilin pathway in regulating endocytic trafficking of EGF receptor in human breast cancer cells

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