Cancer-induced systemic myeloid dysfunction: Implications for treatment and a novel nanoparticle approach for its correction

Alvarez, Rydell; Oliver, Liliana; Valdés, Aymé Fernández-Calienes; Mesa, Circe

doi:10.1053/j.seminoncol.2018.05.001

Cited by 12 publications

(14 citation statements)

References 127 publications

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“…Many cancers are linked to chronic inflammation (Chen and Mellman, 2017;Diakos et al, 2014) and alterations of myelopoiesis during tumor development and progression are known for quite some time (Olsson and Olofsson, 1990;Young and Wright, 1992;Young et al, 1990). Because of these alterations, myeloid cells with a pre-mature phenotype and suppressive function can be observed within or in proximity of tumors (for recent review, see Alvarez et al, 2018;Tcyganov et al, 2018;Ugel et al, 2015;Veglia et al, 2018). MicroRNAs including miR-142-3p seem to normally prevent the differentiation of macrophages toward a suppressive phenotype, a mechanism that is lost during cancer-induced myelopoiesis mediated by tumor-released cytokines signaling through gp130, the common subunit of the IL-6 cytokine receptor family (Sonda et al, 2013).…”

Section: Myelopoiesis In Context Of Acute and Chronic Inflammationmentioning

confidence: 99%

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

2019

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Myelopoiesis ensures the steady state of the myeloid cell compartment. Technological advances in fate mapping and genetic engineering, as well as the advent of single cell RNA-sequencing, have highlighted the heterogeneity of the hematopoietic system and revealed new concepts in myeloid cell ontogeny. These technologies are also shedding light on mechanisms of myelopoiesis at homeostasis and at different phases of infection and inflammation, illustrating important feedback loops between affected tissues and the bone marrow. We review these findings here and revisit principles in myelopoiesis in light of the evolving understanding of myeloid cell ontogeny and heterogeneity. We argue for the importance of system-wide evaluation of changes in myelopoiesis and discuss how even after the resolution of inflammation, long-lasting alterations in myelopoiesis may play a role in innate immune memory or trained immunity.

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Section: Myelopoiesis In Context Of Acute and Chronic Inflammationmentioning

confidence: 99%

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

2019

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“…White blood cells activate innate and adaptive immune responses when challenged by foreign elements. Such interactions between nanoparticle and APCs may affect granulocyte differentiation (myelopoiesis and lymphopoiesis) 61 . Nanostructure conjugated with responsive polymers are also influenced by tissue temperature and pH, producing distinct humoral responses after changing the matrix conformation 58–60 .…”

Section: Discussionmentioning

confidence: 99%

“…Such interactions between nanoparticle and APCs may affect granulocyte differentiation (myelopoiesis and lymphopoiesis). 61 Nanostructure conjugated with responsive polymers are also influenced by tissue temperature and pH, producing distinct humoral responses after changing the matrix conformation. [58][59][60] For example, the reduction in pH after nanoparticle evade the circulatory system into the tumor microenvironment will expose or hide functional groups that allow for the adsorption of blood components.…”

Section: Discussionmentioning

confidence: 99%

Cancer cell membrane‐derived nanoparticles block the expression of immune checkpoint proteins on cancer cells and coordinate modulatory activity on immunosuppressive macrophages

Comparetti

Lins

Quitiba

et al. 2022

J Biomedical Materials Res

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“…In the last few years, growing translational evidence has definitively established immunoediting as a prominent hallmark in BC that should not be overlooked [22][23][24][25][26][27]. Relationship between the presence of TILs and MDSCs in the tumoral microenvironment (TME) and the response to treatment and survival of patients has been described.…”

Section: Discussionmentioning

confidence: 99%

Circulating Immune Biomarkers in Peripheral Blood Correlate With Clinical Outcomes in Advanced Breast Cancer

Palazón‐Carrión

Jiménez‐Cortegana

Sánchez-León

et al. 2021

Preprint

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Identification of the different elements intervening at the immunoedition process, in each body compartment, seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, regulatory T cells, and OX40+ and PD-1+ T lymphocytes counts) in peripheral blood of patients diagnosed with advanced breast cancer, were analyzed prior to and along the implementation of first line antineoplastic therapy. Subsequently, a formal comparison between groups with clinical benefit versus progression of disease and with a healthy women cohort was executed. Results reflected that patients basally showed higher levels of myeloid derived suppressor cells (35.43, IR=180.73 vs 17.53, IR=16.96 cells/μl; p=0.001) and regulatory T cells (32.05, IR=29.84 vs 22.61, IR=13.57 cells/μl; p=0.001) in comparison with healthy women. Furthermore, after therapy, an increase in the number of activated T lymphocytes (expressing OX40), and a decrease of immune inhibitory cells (MDSCs, and Tregs), and the number of inhibited (or exhausted) T lymphocytes (expressing PD-1), could be ascertained in patients with clinical benefit (p≤0.001). The opposite trend was observed in the case of disease progression. These findings suggest that some critical immune elements can be easily detected and measured in peripheral blood, which open a new opportunity for translational research, as they seem to be clearly correlated with clinical evolution, at least in ABC.

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Cancer-induced systemic myeloid dysfunction: Implications for treatment and a novel nanoparticle approach for its correction

Cited by 12 publications

References 127 publications

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

Cancer cell membrane‐derived nanoparticles block the expression of immune checkpoint proteins on cancer cells and coordinate modulatory activity on immunosuppressive macrophages

Circulating Immune Biomarkers in Peripheral Blood Correlate With Clinical Outcomes in Advanced Breast Cancer

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