Cancer Incidence, Mortality, and Blood Lead Levels Among Workers Exposed to Inorganic Lead

Gwini, Stella May; MacFarlane, Ewan; Monaco, Anthony Del; McLean, Dave; Pisaniello, Dino; Benke, Geza; Sim, Malcolm Ross

doi:10.1016/j.annepidem.2012.01.003

Cited by 36 publications

(33 citation statements)

References 29 publications

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“…In a study conducted by Lustberg M. et al it was found that individuals who had high levels of lead had increased cancer-caused mortality due to lung cancer and nonlung cancer [23]. According to epidemiological study that was performed by Gwini et al, among workers exposed to inorganic lead, esophageal cancer was sevenfold greater among those with a blood lead level result above 30 μg/dL compared with population rates [24]. These results are consistent with our current study.…”

Section: Discussionsupporting

confidence: 83%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p < 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p < 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

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Section: Discussionsupporting

confidence: 83%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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“…An early review by Wong and Raabe (2000), which was confined to lead exposure related to petroleum workers, reported no association. Another investigation (Siddiqui et al, 2002) from India, concluded that environmental exposure of ageing males to lead might be a risk factor, but more recent studies by Lam et al (2007) and Gwini et al (2012) reported that lead was not associated with prostate cancer. Overall, the evidence pertaining to lead is inconsistent and it is unlikely occupational exposure to lead is associated with prostate cancer incidence.…”

Section: Heavy and Toxic Metalsmentioning

confidence: 99%

An Update on Occupation and Prostate Cancer

Doolan¹,

Benke²,

Giles³

2014

Asian Pacific Journal of Cancer Prevention

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Background: Our aim was to identify gaps and limitations in the current literature and to make recommendations for future research required to address these. Materials and Methods: We reviewed occupational exposures and related factors associated with the risk of prostate cancer between 2000 and 2012. These included chemical, ergonomic, physical or environmental, and psychosocial factors which have been reported by epidemiological studies across a range of industries. Results: The results are inconsistent from study to study and generally this is due to the reliance upon the retrospectivity of case-control studies and prevalence (ecological) studies. Exposure assessment bias is a recurring limitation of many of the studies in this review. Conclusions: We consider there is insufficient evidence to implicate prostate cancer risk for ergonomic, physical, environmental or psychosocial factors, but there is sufficient evidence to implicate toxic metals, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs). More research is required to identify specific pesticides that may be associated with risk of prostate cancer.

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“…Higher Pb contents were linked to cancers of the gastrointestinal, brain, breast, lung, and bladder and leukemia (Alatise and Schrauzer 2010;Gwini et al 2012;Pasha et al 2010;Van Wijngaarden and Dosemeci 2006). There are some lines of evidence that suggest that Pb increases the susceptibility to cancer.…”

Section: Discussionmentioning

confidence: 97%

“…Many epidemiological studies have reported that oral cancer is strongly associated with tobacco and alcohol drinking (Kazi et al 2010a;Kingsley et al 2008 (Gwini et al 2012). Higher Pb contents were linked to cancers of the gastrointestinal, brain, breast, lung, and bladder and leukemia (Alatise and Schrauzer 2010;Gwini et al 2012;Pasha et al 2010;Van Wijngaarden and Dosemeci 2006).…”

Section: Discussionmentioning

confidence: 98%

Estimation of lead in biological samples of oral cancer patients chewing smokeless tobacco products by ionic liquid-based microextraction in a single syringe system

Arain

Kazi

Arain

et al. 2015

Environ Sci Pollut Res

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Several studies have reported that the chewing habit of smokeless tobacco (SLT) has been associated with oral cancer. The aim of the present study was to evaluate the trace levels of lead (Pb) in biological samples (blood, scalp hair) of oral cancer patients and referents of the same age group (range 30-60 years). As the concentrations of Pb are very low in biological samples, so a simple and efficient ionic liquid-based microextraction in a single syringe system has been developed, as a prior step to determination by flame atomic absorption spectrometry. In this procedure, the hydrophobic chelates of Pb with ammonium pyrrolidinedithiocarbamate (APDC) were extracted into fine droplets of 1-butyl-3-methylimidazolium hexafluorophosphate [C4MIM][PF6] within a syringe while using Triton X-114 as a dispersant. Factors influencing the microextraction efficiency and determination, such as pH of the sample, volume of [C4MIM][PF6] and Triton X-114, ligand concentration, and incubation time, were studied. To validate the proposed method, certified reference materials were analyzed and the results of Pb(2+) were in good agreement with certified values. At optimum experimental values of significant variables, detection limit and enhancement factor were found to be 0.412 μg/L and 80, respectively. The coexisting ions showed no obvious negative outcome on Pb preconcentration. The proposed method was applied satisfactorily for the preconcentration of Pb(2+) in acid-digested SLT and biological samples of the study population. It was observed that oral cancer patients who consumed different SLT products have 2-3-fold higher levels of Pb in scalp hair and blood samples as compared to healthy referents (p < 0.001). While 31.4-50.8% higher levels of Pb were observed in referents chewing different SLT products as compared to nonconsumers (p < 0.01).

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Cancer Incidence, Mortality, and Blood Lead Levels Among Workers Exposed to Inorganic Lead

Cited by 36 publications

References 29 publications

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

An Update on Occupation and Prostate Cancer

Estimation of lead in biological samples of oral cancer patients chewing smokeless tobacco products by ionic liquid-based microextraction in a single syringe system

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