Cancer incidence in a male adult population in relation to estimated protracted colon dose – A nested case control study in Northern Sweden after the Chernobyl Nuclear Power Plant accident

Tondel, Martin; Nordquist, Tobias; Isaksson, Mats; Rääf, Christopher; Wålinder, Robert

doi:10.1016/j.scitotenv.2022.156349

Cited by 4 publications

(11 citation statements)

References 23 publications

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“…The model has been applied in e.g. Tondel et al (2022) to compute time-integrated internal and external dose between the period 1986 to 2015 in Swedish males living in a selection of counties with various fallout.…”

Section: Introductionmentioning

confidence: 99%

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Estimating the organ absorbed dose in Swedish inhabitants following the Chernobyl Nuclear Power Plant accident with the R package absorbedDose

Tondel¹,

Gabrysch²,

Rääf³

et al. 2023

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Section: Introductionmentioning

confidence: 99%

“…A esd,county , Fsnow,county, c milk,county and E inh,county values per county. Values A esd,county are taken fromByström (2000) andTondel et al (2022). Values Fsnow,county are taken fromFinck (1992).…”

mentioning

confidence: 99%

Estimating the organ absorbed dose in Swedish inhabitants following the Chernobyl Nuclear Power Plant accident with the R package absorbedDose

Tondel¹,

Gabrysch²,

Rääf³

et al. 2023

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“…Epidemiological cancer research following the Chernobyl NPP accident aimed at estimating the effects of protracted radiation exposure has often relied only on the external absorbed dose, ignoring the contribution from the internal dose. [11][12][13]26,35 Table 5.…”

Section: Discussionmentioning

confidence: 99%

“…Cancers previously associated with radiation exposure were lumped together in a category named organ-specific cancer (stomach, colon, liver, lung, prostate, urinary bladder, thyroid, and leukemia) showing an adjusted hazard ratio (HR) of 1.019 (95% CI = 1.014, 1.024) per mGy during the follow-up period of 1991 to 2015. 26 We have now expanded this study to include females and children and have extended the follow-up period by 5 years to December 31, 2020. Moreover, we have refined our radiation dose model so that it is now possible to estimate the absorbed dose to each body organ.…”

Section: Introductionmentioning

confidence: 99%

Dose–response analysis of protracted absorbed organ dose and site-specific cancer incidence in Sweden after the Chernobyl nuclear power plant accident

Tondel,

Nordquist,

Isaksson

et al. 2023

Environmental Epidemiology

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Background: Adult males in Sweden exhibit an increased risk of cancer associated with an increased absorbed dose to the colon from the Chernobyl accident. Methods: A closed cohort, with information on hunter status, included all individuals living in northern Sweden in 1986. Complete annual information on exposure to 137Cs at the dwelling coordinate was available for a total of 2,104,101 individuals. A nested case-control method with four controls matched for year of cancer diagnosis and year of birth, was used. Individual absorbed organ doses were calculated between 1986 and 2020 including external and internal exposure. Hazard ratios (HR) per mGy with 95% confidence intervals (95% CI) were calculated using conditional logistic regression adjusted for rural/nonrural habitat, education level and pre-Chernobyl cancer incidence 1980 to 1985. A total of 161,325 cancer cases in males and 144,439 in females were included. Results: The adjusted HR per mGy for all cancer sites combined was 1.027 (95% CI = 1.022, 1.031) in males and 1.011 (95% CI = 1.006, 1.017) in females. In a post hoc analysis accounting for both remaining confounding from hunter lifestyle and the pre-Chernobyl cancer incidence by county, the adjusted HR per mGy for all cancer sites combined was 1.014 (95% CI = 1.009, 1.019) in males and 1.000 (95% CI = 0.994, 1.006) in females. The post hoc analysis suggested an increased risk of cancer in the colon, pancreas, and stomach, respectively, in males, and lymphoma in females. Conclusions: Increased cancer risk estimates were found for some specific cancer sites but remaining uncontrolled confounding due to hunter lifestyle could not be ruled out.

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“…An inclusion criterium was that the individuals were free of cancer prior to the Chernobyl Nuclear Power Plant accident, and this could be obtained by removing cancer diagnoses registered in the national cancer registry 1958 to 1985. The cancer incidence rate in adult males, a sub-cohort of the full cohort, has recently been analyzed in relation to colon absorbed dose (Tondel et al, 2022). Hence, for the present study we could take advantage of this cohort with information on cancer incidence rate on municipality level up to 2020.…”

Section: Methodsmentioning

confidence: 99%

Average uranium bedrock concentration in Swedish municipalities predicts male lung cancer incidence rate when adjusted for smoking prevalence: Indication of a cumulative radon induced detriment

Rääf

Tondel

Isaksson

et al. 2023

Science of The Total Environment

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Cancer incidence in a male adult population in relation to estimated protracted colon dose – A nested case control study in Northern Sweden after the Chernobyl Nuclear Power Plant accident

Cited by 4 publications

References 23 publications

Estimating the organ absorbed dose in Swedish inhabitants following the Chernobyl Nuclear Power Plant accident with the R package absorbedDose

Estimating the organ absorbed dose in Swedish inhabitants following the Chernobyl Nuclear Power Plant accident with the R package absorbedDose

Dose–response analysis of protracted absorbed organ dose and site-specific cancer incidence in Sweden after the Chernobyl nuclear power plant accident

Average uranium bedrock concentration in Swedish municipalities predicts male lung cancer incidence rate when adjusted for smoking prevalence: Indication of a cumulative radon induced detriment

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