Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA

Cancer risk in hospitalised psoriasis patients: a follow-up study in Sweden

“…For specific cancers, the increased risk of squamous cell skin cancer has been noted by many earlier studies (Chuang et al, 1992;Hannuksela et al, 1996;McKenna et al, 1996;Frentz and Olsen, 1999;Hannuksela-Svahn et al, 2000;Boffetta et al, 2001). The increase is thought to be due to UV exposure, but it may be increased by concomitant treatments.…”

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

“…While some studies suggest an increased risk of lymphoma in patients with psoriasis, [78][79][80][81][82][83][84][85][86] other studies do not support this association. [87][88][89][90][91][92][93][94][95][96][97] The largest study evaluating this association is a retrospective, population-based cohort study that enrolled 153,197 patients with psoriasis and 765,950 matched patients without psoriasis. 98 Patients were identified through the United Kingdom General Practice Research Database and analyses were age, gender and person-time adjusted.…”

“…78,87,102,103 An increased risk of SCC has been convincingly demonstrated for psoriasis patients treated with psoralen and ultraviolet A (PUVA). 80,[103][104][105] Treatment with either coal-tar or cyclosporine also increases the risk of SCC development.…”

“…80,[103][104][105] Treatment with either coal-tar or cyclosporine also increases the risk of SCC development. 80,106,107 Although numerous studies fail to demonstrate an increased risk of melanoma among PUVA-treated psoriasis patients, 80,83,87,91 one group found an increased risk of melanoma among psoriasis patients treated with aggressive PUVA after fifteen years of follow-up. 108,109 Several studies suggest an increased risk of solid malignancies in patients with psoriasis, including oral cavity, esophagus, pharynx, larynx, esophagus, liver, pancreas, lung, bladder, kidney, breast, and colon cancer in women, and cancer of the genital organs, excluding the prostate, in men.…”

Phototherapie und Karzinogenese

“…Insbesondere Cyclosporin, das als krebsfördernde Substanz aus der Transplantationsmedizin bekannt ist [15,17,50], steigert das Risiko, nach PUVA-Behandlung spinozelluläre Karzinome zu entwickeln, um das 7-Fache und entspricht damit etwa dem Gewicht von 200 PUVA-Sitzungen [26]. Während Bade-PUVA grundsätzlich dieselben Risiken für Hautkrebsentstehung wie die klassische systemische PUVA birgt [37], ließ sich bisher noch keine Häufung von Hautkrebs nach Bade-PUVA verzeichnen [12,13].…”