Cancer in the elderly

Petera, Jiřı́; Dušek, Ladislav

doi:10.1016/j.rpor.2012.11.001

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Depending on the site and stage of the cancer, treatment may consist of surgery, radiotherapy, chemotherapy or a combination thereof, accompanied by rehabilitation and social support [2, 45]. For advanced cases, there has been a shift from surgical treatment towards chemoradiotherapy protocols (especially concomitant chemotherapy and radiotherapy).…”

Section: Hnsccmentioning

confidence: 99%

Challenges in organizing effective oncology service: inter-European variability in the example of head and neck cancers

Malicki

2014

Eur Arch Otorhinolaryngol

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The increasing worldwide burden of cancer makes it imperative that every country develop a comprehensive cancer control programme. In the past, cancer control in Central and Eastern Europe was inadequate, particularly when compared to many wealthier Western European countries. We analyse interregional differences in Europe to the approach to comprehensive cancer care, with a focus on head and neck squamous cell carcinoma using the case of Poland as a representative example. Due to national plans major improvements have been achieved in the field of prevention and in radiotherapy delivery having a measurable and positive impact on treatment outcomes. In head and neck cancers a notable move towards multidisciplinary approach has been made, combining surgery, radiotherapy and chemotherapy accompanied by rehabilitation and social support. In Poland and several other Eastern and Central European countries a shortage of physicians in the field of oncology was noted. The main conclusion is that the special plans are needed in Central and Eastern Europe or those existing must be extended for another decade to fulfil the EU requirement of providing all European citizens with equal access to quality cancer care.

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Section: Hnsccmentioning

confidence: 99%

Challenges in organizing effective oncology service: inter-European variability in the example of head and neck cancers

Malicki

2014

Eur Arch Otorhinolaryngol

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“…Epithelial ovarian cancers represent nearly 90% of all ovarian cancers and develop mainly in postmenopausal women [25]. In parallel with an increase in life expectancy, the rate of female reproductive cancer incidence has nearly doubled in the past 30 years [26]. The current hypothesis, supported by epidemiological and experimental evidence, suggests that repetitive ovulation and wounding of the ovarian surface during reproductive life can increase the risk of epithelial ovarian cancers [25], and most ovarian cancers usually develop immediately after menopause [27].…”

Section: Introductionmentioning

confidence: 99%

Changes of Ovarian microRNA Profile in Long-Living Ames Dwarf Mice during Aging

et al. 2017

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The Ames dwarf (df/df) mice have extended longevity and can preserve the ovarian reserve longer than Normal (N) mice. Based on this, the aim of our study was to evaluate the ovarian microRNA (miRNA) profile in young and aged df/df and N mice. Ovarian tissue was collected at 5–6 months and at 21–22 months of age for miRNA sequencing. We detected a total of 404 miRNAs in the ovarian samples, from which the abundance of 22 and 33 miRNAs changed with age in N and df/df mice, respectively. Of these, only three miRNAs were commonly regulated with age between N and df/df mice, indicating a very divergent miRNA profile between genotypes. We also detected that 46 miRNAs were regulated between N and df/df mice, of which 23 were regulated exclusively in young mice, 12 exclusively in old mice and 12 commonly regulated at young and old ages. Many genes likely to be targeted by these miRNAs are involved in the FoxO, mTOR, PI3k/Akt and insulin signaling pathways. These results suggest that the aging process has a differential impact on the ovarian miRNA profile in df/df mice, and suggest that these miRNAs can be central players in the maintenance of a younger ovarian phenotype.

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“…There are no clear guidelines on treatment of elderly patients as they are underrepresented in clinical trials. [8,9] Studies have shown that the proportion of patients receiving non-standard treatment increases to around 64% with increasing age of the patient. [10,11] The percentage of patient offered no treatment also increases to 18%, as the age of patient increases.…”

Section: Introductionmentioning

confidence: 99%