Cancer in the anal canal, and in an anal fistula, that developed during a longstanding course of Crohn's disease

Kazama, Shinsuke; Hiramatsu, Takeyuki; Kobayashi, Ryo; Takabayashi, Naoki; Niwa, Hitoshi; Isono, Tadahiro; Suzuki, Hitoshi; Shimada, Shogo; Kimura, Mitsutoshi; Hara, Kosuke; Kuriki, Ken

doi:10.1007/s00535-005-1668-y

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…reported 24/64 (37%) right‐sided colon cancer cases and 40/64 (63%) left‐sided CRC cases. From the total review of 17 studies with 107 cases from Asia, we identified 90/107 (84.1%) patients with left‐sided CRC and 17/107 (15.9%) patients with right‐sided colonic cancer 15,25–40 . The locations of cancer in patients with CD were significantly different among countries ( P < 0.01).…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of 52 studies reporting data from 208 patients with ARC are shown in Table 2 11,15,19,23,25,28,30,34,36–80 . Although many reports did not describe the details of each characteristic, the median survival prognosis was 2.1 ± 2.3 years in 74 patients, and advanced cancer greater than stage T3 occurred in 46/74 (62.1%) patients.…”

Section: Resultsmentioning

confidence: 99%

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Intestinal cancer in patients with Crohn's disease: A systematic review and meta‐analysis

Uchino

Ikeuchi

Hata

et al. 2020

J of Gastro and Hepatol

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Background and Aim Although surveillance colonoscopy is recommended by several guidelines for Crohn's disease (CD), the evidence is insufficient to support the validity of this recommendation. Moreover, the efficacy of surveillance colonoscopy for anorectal cancer remains unclear. Therefore, we performed a systematic review of cancer in patients with CD before considering the proper surveillance methods. Methods We conducted a systematic review and meta‐analysis examining the incidence of intestinal cancer and a literature review to clarify the characteristic features of cancer in CD. We performed the systematic literature review of studies published up to May 2019. Results Overall, 7344 patients were included in eight studies. The standardized incidence ratios (95% confidence intervals) of colorectal cancer (CRC) and small bowel cancer (SBC) were 2.08 (1.43–3.02) and 22.01 (9.10–53.25), respectively. The prevalence of CRC and SBC was 57/7344 (0.77%) and 17/7344 (0.23%), respectively, during a median follow‐up of 12.55 years. Additionally, 54 studies reporting 208 anorectal cancer cases were identified. In patients with anorectal cancer, the prognosis for survival was 2.1 ± 2.3 years, and advanced cancer greater than stage T3 occurred in 46/74 patients (62.1%). Many more reports of anorectal cancer were published in Asia than in Western countries. Conclusion Although we were unable to state a recommendation for surveillance for SBC, we should perform cancer surveillance for CRC in patients with CD. However, the characteristics of cancer may differ according to geography or race. We must establish proper and effective surveillance methods that are independently suitable to detect these differences.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Intestinal cancer in patients with Crohn's disease: A systematic review and meta‐analysis

Uchino

Ikeuchi

Hata

et al. 2020

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…11,15 However, virtually all of the patients in this series experienced a change in the severity of pain or symptoms, such as discharge, and this has been reported by others. 7,9,13,10,22 A change in symptoms in this population should alert physicians to the possibility of cancer and the need for investigation. In this series, even in patients in whom the diagnosis was made preoperatively, patients required repeated biopsies before the diagnosis was made, suggesting that there may have been a delay.…”

Section: Discussionmentioning

confidence: 99%