Cancer in pregnancy. Part I: basic diagnostic and therapeutic principles and treatment of gynecological malignancies

Hoellen, Friederike; Reibke, Roland; Hornemann, Katrin; Thill, Marc; Luedders, Doerte W.; Kelling, Katharina; Hornemann, Amadeus; Bohlmann, Michael K.

doi:10.1007/s00404-011-2058-8

Cited by 23 publications

(37 citation statements)

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“…1:5000 bis 1:10.000 Schwangerschaften gestellt [30], die Inzidenz ist in Industrieländern insgesamt deutlich geringer als in Schwellen-und Entwicklungsländern [31]. Unter den in der Schwangerschaft diagnostizierten Krebserkrankungen rangiert das Zervixkarzinom hinter dem malignen Melanom an zweiter Stelle [32]. [14,32].…”

Section: Management Des Zervixkarzinoms In Der Schwangerschaftunclassified

“…Unter den in der Schwangerschaft diagnostizierten Krebserkrankungen rangiert das Zervixkarzinom hinter dem malignen Melanom an zweiter Stelle [32]. [14,32]. In ca.…”

Section: Management Des Zervixkarzinoms In Der Schwangerschaftunclassified

“…Die Möglichkeiten der klinischen Stadieneinteilung mittels gynäko-logischer Tastuntersuchung und Beurteilung der Parametrien sind in der Schwangerschaft deutlich begrenzt. An bildgebenden Verfahren kommt in der Schwangerschaft neben dem Ultraschall nur eine Magnetresonanztomographie (MRT; im ersten Trimenon ohne kontrastgebendes Gadolinium) in Frage [32]. Da Gadolinium plazentagängig ist, sollte es insgesamt zurückhaltend eingesetzt werden, entsprechend der aktuellen Datenlage sind bisher jedoch keine teratogenen Effekte beschrieben [30].…”

Section: Management Des Zervixkarzinoms In Der Schwangerschaftunclassified

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Kinderwunsch und Schwangerschaft bei Zervixkarzinom und Vorstufen

2016

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Section: Management Des Zervixkarzinoms In Der Schwangerschaftunclassified

“…Unter den in der Schwangerschaft diagnostizierten Krebserkrankungen rangiert das Zervixkarzinom hinter dem malignen Melanom an zweiter Stelle [32]. [14,32]. In ca.…”

Section: Management Des Zervixkarzinoms In Der Schwangerschaftunclassified

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Kinderwunsch und Schwangerschaft bei Zervixkarzinom und Vorstufen

2016

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“…As the data of the National Cancer Register shows, in Poland the prevalence of cervical cancer has been decreasing since the mid-1980s, with 2909 new cases and 1669 deaths from malignant tumours in this location, registered in 2013 [7]. Almost 3% of cases of cervical cancer occur during pregnancy and in the post-partum period and the frequency of diagnosing cervical cancer in pregnancy is 1:1000 pregnancies [8][9][10][11][12]. The average age of women with cervical cancer diagnosed in pregnancy is 31 years.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy-related cervical cancer in the material of the Regional Cancer Centre, Łódź, between 2011 and 2014

Danielska¹,

Moszyńska-Zielińska²,

Gottwald³

et al. 2017

Nowotwory. Journal of Oncology

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Introduction. Pregnancy-related cancer is defined as cancer diagnosed during pregnancy or in the first postpartum year. Cervical cancer affects approximately 1 in 1000 pregnant women and is the most common malignancy affecting pregnancy. We retrospectively analysed the clinical outcome and results of treatment in patients with pregnancy--related cervical cancer. Material and methods. We retrospectively analysed the medical records of nine patients with invasive cervical cancer diagnosed during pregnancy and the postpartum period who had been treated in the Regional Oncological Centre, Łódź, between 2011-2014. Results. Three patients with cervical cancer at stage I were diagnosed between the 14 th and 17 th week of pregnancy afterwards and underwent radical surgery. Two patients with cervical cancer at stage Ib who were diagnosed in the 19 th and 24 th week of gestation decided to continue pregnancy until the 30 th and 32 nd week; then a cesarean section combined with radical surgery was performed. In three patients with inoperative cervical cancer diagnosed between the 26 th and 28 th week of pregnancy, a cesarean section was performed at week 30-32. In one patient cervical cancer at stage IIb was diagnosed during the post-partum period. All patients were treated using intensity-modulated radiotherapy (IMRT) to a total dose of 44 Gy/2Gy, weekly cisplatin (40 mg/m 2 ) concurrent with radiotherapy and brachytherapy. No toxicity was observed. During follow-up, two patients with inoperable cervical cancer were diagnosed with a recurrence 2 and 10 months after treatment, respectively. Conclusions. The management of pregnancy-related cervical cancer is mainly determined by the week of the pregnancy and the stage of the disease at diagnosis, but also by the patient choice. The general condition and follow-up of newborns from pregnancies complicated by cervical cancer are similar to those of newborns arising from non--complicated pregnancies. Treatment toxicity is similar in cases with pregnancy-related cervical cancer and in non--pregnant women with cervical cancer. The major prognostic factor in pregnancy-related cervical cancer remains the stage of the disease at diagnosis. NOWOTWORY J Oncol 2016; 66, 5: 359-366

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“…The cancer is a strange condition during the pregnancy. This coincidence is estimated in one of each 1000 gestations [5]. Every year they are diagnosed in the United States between 3 500 and 6 000 new cases of wicked illnesses, representing the third part of the maternal deaths [6].…”

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confidence: 99%