1984
DOI: 10.1136/bmj.288.6418.659
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Cancer in organ transplant recipients: part of an induced immune deficiency syndrome.

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Cited by 38 publications
(9 citation statements)
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“…The finding that 48'^,, of the patients suffered from warts is similar to previous reports (Spencer & Andersen, 1979;Boyle etal, 1984). The effect of graft survival time upon the onset of warts and skin lesions, already observed by Sheil (1984), was well illustrated in this study, in which the prevalence rose from 15" " at the end of the first year to 87" " after the fifth year. This difference is in fact even greater as the presence of warts at the time of transplant represents a larger proportion of the warts in tbe early group than in the late group; 5",, of patients in the early group had new warts, and 80",, in the late group.…”
Section: Discussionsupporting
confidence: 79%
“…The finding that 48'^,, of the patients suffered from warts is similar to previous reports (Spencer & Andersen, 1979;Boyle etal, 1984). The effect of graft survival time upon the onset of warts and skin lesions, already observed by Sheil (1984), was well illustrated in this study, in which the prevalence rose from 15" " at the end of the first year to 87" " after the fifth year. This difference is in fact even greater as the presence of warts at the time of transplant represents a larger proportion of the warts in tbe early group than in the late group; 5",, of patients in the early group had new warts, and 80",, in the late group.…”
Section: Discussionsupporting
confidence: 79%
“…Several theories have been suggested to explain the high incidence of abnormal smears. Sheil (1984) stresses the important role of the induced immunosuppressive state of the renal transplant patient. As human papillomavirus may play a major role in the development of cervical neoplasia, a possible explanation would be an increased infection rate of renal transplant patients with oncogene human papillomavirus, as is found in patients positive for the human immunodeficiency virus (Williams et al 1994).…”
Section: Discussionmentioning
confidence: 99%
“…Antirejection medications induce a state of iatrogenic depression of immune surveillance, suggested to be a condition permissive for the development of malignancy. 18,27,28 However, it also was suggested that such immunosuppressive agents as azathioprine 29,30 and CyA 31 have intrinsic properties that favor the establishment of de novo malignancies. Potential mechanisms range from inherent carcinogenic properties of antiproliferative agents to alterations in the cytokine milieu associated with CyA (and perhaps tacrolimus) to an independent effect on cell-adhesive properties.…”
Section: Role Of Immunosuppressionmentioning
confidence: 99%