Cancer in indigenous people in <scp>L</scp>atin <scp>A</scp>merica and the <scp>C</scp>aribbean: a review

Moore, Suzanne P.; Forman, David; Piñeros, Marion; Fernández, Sdenka M.; Santos, Marceli de Oliveira; Bray, Freddie

doi:10.1002/cam4.134

Cited by 55 publications

(47 citation statements)

References 66 publications

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“…In this study, the ratio of transition in Bolivia was 60%, which is comparable with that in Japan (69%), but not comparable with those in Chile (100%) and Hungary (90%). Bolivia and Chile share similarities in terms of location and indigenous populations (Moore et al, 2014); however, the ratios of transition between these neighboring countries are significantly different (P < 0.05). These results demonstrate that geographic and ethnic variation contribute to mutational characteristics.…”

Section: Gc->cg 20%mentioning

confidence: 91%

High Frequency of TP53 but not K-ras Gene Mutations in Bolivian Patients with Gallbladder Cancer

Asai

Loza²,

Roig³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Although genetic characteristics are considered to be a factor influencing the geographic variation in the prevalence of gallbladder cancer (GBC), they have not been well studied in Bolivia, which has a high prevalence rate of GBC. The purpose of this study was to examine the frequency of TP53 and K-ras mutations in Bolivian patients with GBC and to compare them with our previous data obtained in other high-GBC-prevalence countries, namely Japan, Chile, and Hungary. DNA was extracted from cancer sites in paraffin-embedded tissue from 36 patients using a microdissection technique. TP53 mutations at exons 5 to 8 and K-ras mutations at codons 12, 13 and 61 were examined using direct sequencing techniques. The data obtained were compared with those in the other high-GBC-prevalence countries. Of the 36 patients, 18 (50.0%) had a TP53 mutation (one mutation in each of 17 patients and three mutations in one patient), and only one (2.8%) had a K-ras mutation. Of the 20 TP53 mutations, 12 were of the transition type (60.0%). This rate was significantly lower than that in Chile (12/12, P<0.05). In addition, three mutations were of the CpG transition type (15.0%), which is a feature of endogenous mutation. All three were found in the hot spot region of the TP53 gene. In contrast, G:C to T:A transversion was found in Bolivia, suggesting the presence of exogenous carcinogens. Our findings suggest that the development of GBC in Bolivia is associated with both exogenous carcinogens and endogenous mechanisms. The identification of an environmental risk factor for GBC is needed to confirm these findings.

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Section: Gc->cg 20%mentioning

confidence: 91%

High Frequency of TP53 but not K-ras Gene Mutations in Bolivian Patients with Gallbladder Cancer

Asai

Loza²,

Roig³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Lower cancer incidence rates and poorer outcomes in indigenous compared to nonindigenous populations living in the same country were also reported. (17) Communicable diseases continue to be a significant cause of morbidity and mortality in developing countries, particularly in low income communities. However lifestyle changes driven by economic development and globalization led to concurrent NCD emergence.…”

Section: Discussionmentioning

confidence: 99%

1027 Disparities in cancer epidemiology and care delivery among Brazilian indigenous populations

Samora¹,

Aguiar²,

Stock³

et al. 2015

European Journal of Cancer

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Objective: To assess aspects related to cancer in indigenous population. Methods: This is a retrospective study developed in a public university hospital. We included patients with 18 or more years of age, diagnosed with solid tumors, and followed between 2005 and 2015. Clinical features were assessed by descriptive statistics, and survival was evaluated by Kaplan-Meier curves and multivariate Cox regression. Results: Fifty patients were included. The cancer incidence was 15.73 per 100,000. The mean age at diagnosis was 54 years and most patients were female (58%). Cancer of the cervix (28%) and prostate (16%) were the most common. The mean time between the onset of symptoms and the diagnosis was 9 months and from diagnosis to the treatment was 3.4 months. Disease diagnosed at stage IV (17%) had worse overall survival (HR: 11.4; p<0.05). The 5-year survival rate ranged from 88% for prostate cancer to 0% for lung cancer. All 5-year survival rates were lower as compared to other populations. Conclusion: The most prevalent cancer sites were cervix and prostate. Disease stage and primary site were prognostic factors.

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“…Los principales factores de riesgo que han sido estudiados en relación al cáncer en general son el tabaco, alcohol, agentes infecciosos, radiación ionizante, agentes químicos, patrones dietarios y la obesidad (16)(17)(18)(19). Específicamente para el CVB, se han identificado como componentes de riesgo ser de sexo femenino, colelitiasis, obesidad, etnia, inflamación crónica, historia de enfermedades infecciones como H. pylori e historia familiar de cáncer (6,15).…”

Section: Factores De Riesgo Para Cáncer De Vesículaunclassified

“…La incidencia es baja en la población caucásica de los Estados Unidos y en la mayoría de los países de Europa occidental, en cambio es muy alta en Asía y Latinoamérica (12,16,17). La etnia mapuche presenta la tasa más alta de vesícula biliar a nivel mundial (25,26).…”

Section: Etnia Y Región Geográficaunclassified

“…El estudio realizado por Bertran (8) señala que la población de la ciudad de Valdivia, Chile, manifestó una incidencia cruda de cán-cer de vesícula de 17,8 por 100.000 habitantes y un SIR ajustado por edad de 17,5 (CI 95%; 15,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]4). En este estudio, el 76% de los casos fueron mujeres, con una incidencia cruda de 26,7 y un SIR de 24,3 (CI 95%; 21,2-27,4).…”

Section: Etnia Y Región Geográficaunclassified

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Cáncer de vesícula biliar en Chile y factores nutricionales de riesgo

Rosenblatt

Agüero

2016

Nutr Hosp

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Gallbladder cancer is the most malign neoplasm of the biliary tract. Chile presents the third highest prevalence of gallbladder cancer in the Americas, being Chilean women from the city of Valdivia the ones with the highest prevalence. The main risk factors associated with gallbladder cancer are: sex, cholelithiasis, obesity, ethnicity, chronic inflammation, history of infection diseases such as Helicobacter pylori and Salmonella and family history of gallbladder cancer. In Chile gallbladder cancer mortality is close to prevalence level. This is related to the silent symptomatology of this cancer, as well as the lack of specific symptoms. The high prevalence of obesity and infectious diseases present in Chile are two of the main risk factors of gallbladder cancer and Chile has prevalence of obesity close to 30% The aim of this literary review is to inform and summarize the main risk factors of gallbladder cancer that are prevalent in Chile, in order to be able to focus preventive and management interventions of this risk factor for the reduction in prevalence and mortality of gallbladder cancer in Chile.Cáncer de vesícula biliar en Chile y factores nutricionales de riesgo ResumenEl cáncer de vesícula biliar es la neoplasia maligna más común en el tracto biliar. Chile presenta la tercera prevalencia más alta de cáncer de vesícula en el continente americano, siendo las mujeres chilenas de la ciudad de Valdivia las que presentan la prevalencia más alta. Los principales factores que se han asociado al cáncer de vesícula son: ser mujer, colelitiasis, obesidad, etnia, inflamación crónica, historia de enfermedades infecciones, como H. pylori y Salmonella e historia familiar de cáncer. En Chile la mortalidad por cáncer de vesícula es cercana al nivel de prevalencia. Esto se debe en parte a que el cáncer de vesícula es una enfermedad silenciosa y sin síntomas específicos en primeras instancias. Presentar obesidad y ser portador de agentes infecciosos, como Helicobacter pylori, son dos de los factores de riesgo más importantes para desarrollar cáncer de vesícula en Chile, ya que existe y una prevalencia de obesidad cercana al 30%. El objetivo de esta revisión literaria es informar y resumir los factores de riesgo de cáncer de vesícula prevalentes en Chile, para así enfocarse en la prevención y cuidado de estos, con el propósito de reducir la prevalencia de esta letal enfermedad.

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Cancer in indigenous people in Latin America and the Caribbean: a review

Cited by 55 publications

References 66 publications

High Frequency of TP53 but not K-ras Gene Mutations in Bolivian Patients with Gallbladder Cancer

High Frequency of TP53 but not K-ras Gene Mutations in Bolivian Patients with Gallbladder Cancer

1027 Disparities in cancer epidemiology and care delivery among Brazilian indigenous populations

Cáncer de vesícula biliar en Chile y factores nutricionales de riesgo

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