Cancer in Biopsy-Proven Giant Cell Arteritis. A Population-Based Study

Lopez-Diaz, Maria J.; Martinez-Lado, Luciana; Peña-Sagredo, J L; Lopez-Agreda, Hugo; Miranda‐Filloy, José A.; González‐Juanatey, Carlos; Sánchez-Andrade, A; Martín, Javier; Llorca, Javier

doi:10.1016/j.semarthrit.2007.03.006

Cited by 34 publications

(27 citation statements)

References 39 publications

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“…This finding has been previously described by two other reports. In the one report, PMR symptoms improved after specific treatment for prostate cancer, initially with cyproterone acetate and luteinizing hormone-releasing hormone analogue at a later stage [24]. In the other report of PMR simultaneously diagnosed with nonmetastatic renal cell carcinoma, nephrectomy led to the resolution of systemic complaints [26].…”

Section: Discussionmentioning

confidence: 99%

“…In cases of breast cancer, development of vasculitis has been reported during treatment with tamoxifen or with an aromatase inhibitor [22,23]. However, other epidemiologic studies do not support a potential association between GCA and cancer [24]. Giant cell arteritis of the breast may mimic breast cancer, and especially inflammatory breast cancer, as its main clinical manifestations include a palpable mass and/or inflammatory features of the skin covering the anatomical sites affected by vasculitis.…”

Section: Discussionmentioning

confidence: 99%

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Giant Cell Arteritis of the Breast and Breast Cancer: Paraneoplastic Manifestation or Concomitant Disease? A Case Report

Kafantari

Sotiropoulou²,

Sfikakis³

et al. 2008

Oncol Res Treat

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Background: Giant cell arteritis (GCA) of the breast is one of the less recognized variants of this vasculitis and may represent an isolated finding or a manifestation of a more widespread disease. Case Report: We present the case of a 74-year-old woman with malaise and a 14-day persistent fever, reaching 38°C. There was a bilateral, painless and mobile axillary lymphadenopathy and a slight tenderness over the medial and lateral upper quadrants of her left breast, as well as an independent palpable tender mass in the upper outer quadrant of the same breast measuring 2 cm in its greatest diameter. Constitutional symptoms, anemia and an elevated erythrocyte sedimentation rate suggestive of polymyalgia rheumatica were also present. An invasive ductal carcinoma of the breast with coincidental pathologic findings of GCA in the same biopsy specimen was revealed. In this case, arteritis was limited to the breast and presented with diffuse breast tenderness. No other artery was involved by GCA. All arteritis-related symptoms disappeared after the removal of the tumor. Conclusions: There is a relationship between cancer, particularly breast cancer, and GCA of the same organ, but the real nature of this association still remains unknown.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Giant Cell Arteritis of the Breast and Breast Cancer: Paraneoplastic Manifestation or Concomitant Disease? A Case Report

Kafantari

Sotiropoulou²,

Sfikakis³

et al. 2008

Oncol Res Treat

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“…In case of paraneoplastic GCA, the immune system would plausibly be activated by tumor secreted agents. GCA has been found to decrease the risk of cancer (11), and does not increase cancer mortality (12). In biopsy-proven cases, however, GCA has been shown to increase the malignancy risk (13).…”

Section: Case Reportmentioning

confidence: 99%

Giant cell arteritis and polymyalgia rheumatica as first manifestation of typical pulmonary carcinoid tumor

Aguiar¹,

Vincent²

2016

Reumatismo

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summary Giant cell arteritis (GCA), a systemic vasculitis of unknown origin, may appear rarely as a paraneoplastic syndrome. Cases secondary to pulmonary neuroendocrine tumors have not been reported. A 75-year-old female developed prednisone-responsive GCA/polymyalgia rheumatica (PMR) shortly followed by syndrome of inappropriate antidiuretic hormone secretion. An 8 mm carcinoid lung tumor with positron emission tomography normal uptake was found. After a thoracoscopic tumor resection the patient experienced complete clinical and laboratory remission. This is the first report of GCA with PMR in the context of carcinoid lung tumor. It emphasizes the role of paraneoplastic vasculitis as a possible cause of GCA.

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“…Three of the above studies included patients with polymyalgia rheumatica (PMR) in addition to subjects with GCA [Ji et al 2010;Myklebust et al 2002;Haga et al 1993]. An additional study evaluated mortality in GCA patients with and without cancer without information on cancer risk and is not reviewed here [Gonzalez-Gay et al 2007]. …”

Section: Giant Cell Arteritismentioning

confidence: 99%

Malignancy Risk in Vasculitis

Kermani¹,

Warrington

Amin

2010

Therapeutic Advances in Musculoskeletal

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The vasculitides encompass a rare subset of autoimmune diseases. Reports of the concurrent association of malignancies with some forms of vasculitis raise the possibility that patients with certain types of vasculitis may be at increased risk of cancer. Conversely, some forms of vasculitis may be a manifestation of malignancy. We review cancer risk in patients with large vessel vasculitis (giant cell arteritis and Takayasu arteritis), polyarteritis nodosa, and the circulating antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides. In addition we discuss vasculitis as a paraneoplastic phenomenon, highlighting polyarteritis nodosa in association with hairy cell leukemia and reviewing the most common vasculitic manifestation of cancer, cutaneous vasculitis.

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Cancer in Biopsy-Proven Giant Cell Arteritis. A Population-Based Study

Cited by 34 publications

References 39 publications

Giant Cell Arteritis of the Breast and Breast Cancer: Paraneoplastic Manifestation or Concomitant Disease? A Case Report

Giant Cell Arteritis of the Breast and Breast Cancer: Paraneoplastic Manifestation or Concomitant Disease? A Case Report

Giant cell arteritis and polymyalgia rheumatica as first manifestation of typical pulmonary carcinoid tumor

Malignancy Risk in Vasculitis

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