Cancer immunotherapy: moving forward with peptide T cell vaccines

Kumai, Takumi; Fan, Aaron E.; Harabuchi, Yasuaki; Celis, Esteban

doi:10.1016/j.coi.2017.07.003

Cited by 55 publications

(49 citation statements)

References 44 publications

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“…The use of peptides as vaccines takes this rationale further, as even a single protein antigen may have many epitopes, not all of which contribute to protective immunity. Peptide vaccines offer a means to formulate vaccines containing only epitopes that are capable of inducing a positive and efficient immune response . The ease of peptide synthesis makes large scale production feasible whilst also offering a cleaner vaccine preparation lacking biological contaminations commonly associated with recombinant expression or whole organism vaccines.…”

Section: Introductionmentioning

confidence: 99%

Disordered epitopes as peptide vaccines

et al. 2018

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The development of clinically useful peptide‐based vaccines remains a long‐standing goal. This review highlights that intrinsically disordered protein antigens, which lack an ordered three‐dimensional structure, represent excellent starting points for the development of such vaccines. Disordered proteins represent an important class of antigen in a wide range of human pathogens, and, contrary to widespread belief, they are frequently targets of protective antibody responses. Importantly, disordered epitopes appear invariably to be linear epitopes, rendering them ideally suited to incorporation into a peptide vaccine. Nonetheless, the conformational properties of disordered antigens, and hence their recognition by antibodies, frequently depend on the interactions they make and the context in which they are presented to the immune system. These effects must be considered in the design of an effective vaccine. Here we discuss these issues and propose design principles that may facilitate the development of peptide vaccines targeting disordered antigens.

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Section: Introductionmentioning

confidence: 99%

Disordered epitopes as peptide vaccines

et al. 2018

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“…The most appropriate vaccine design requires information about the distribution of pathogen genotypes as well as HLA alleles . Through this method, more specific epitopes could be selected which can be valuable to design epitope‐based vaccines to efficiently elicit potent B and T cell responses . On the basis of these observations, we further determined the conserved regions among the vaccine and Indonesian strains.…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic and immunoinformatic analysis of VP4, VP7, and NSP4 genes of rotavirus strains circulating in children with acute gastroenteritis in Indonesia

Nirwati

Donato

Ikram

et al. 2019

Journal of Medical Virology

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Rotavirus is a major cause of diarrhea in Indonesian children. However, rotavirus vaccines have not been introduced in the national immunization program of Indonesia. Understanding the genetic diversity and conserved antigenic regions of circulating strains are therefore essential to assess the potential efficacy of rotavirus vaccines. We collected fecal samples from hospitalized children less than 5 years of age with acute diarrhea. Rotavirus genotyping was performed by reverse transcriptase polymerase chain reaction, followed by sequencing of the VP4, VP7, and NSP4 genes of representative strains. Phylogenetic analysis was performed to investigate their relationship with globally circulating strains. Conservational analysis, immunoinformatics, and epitope mapping in comparison to vaccine strains were also performed. The sequence analyses showed that differences of multiple amino acid residues existed between the VP4, VP7, and NSP4 antigenic regions of the vaccine strains and the Indonesian isolates. However, many predicted conserved epitopes with higher antigenicity were observed in the vaccine and Indonesian strains, conferring the importance of these epitopes. The identified epitopes showed a higher potential of rotavirus vaccine to be employed in Indonesia. It could also be helpful to inform the design of a peptide vaccine based on the conserved regions and epitopes in the viral proteins.

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“…Another way to induce a powerful immune response is via T cell‐based vaccines. Several strategies have been developed to induce specific T cell responses, including peptide‐based CD8 + T cell vaccines or CD4 + helper T cell‐targeted vaccines . Such approaches have been employed for treating cancer and chronic HBV infection .…”

Section: Immune‐based Therapies For Hevmentioning

confidence: 99%

Immunity against hepatitis E virus infection: Implications for therapy and vaccine development

Hakim

Ikram

Zhou

et al. 2017

Reviews in Medical Virology

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Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and patients have improved our understanding of HEV immunopathogenesis and informed the development of new antiviral therapies and effective vaccines. In this review, we discuss the recent progress on innate and adaptive immunity in HEV infection, and the implications for the devolopment of effective vaccines and immune-based therapies.

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Cancer immunotherapy: moving forward with peptide T cell vaccines

Cited by 55 publications

References 44 publications

Disordered epitopes as peptide vaccines

Disordered epitopes as peptide vaccines

Phylogenetic and immunoinformatic analysis of VP4, VP7, and NSP4 genes of rotavirus strains circulating in children with acute gastroenteritis in Indonesia

Immunity against hepatitis E virus infection: Implications for therapy and vaccine development

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