Cancer-immune therapy: restoration of immune response in cancer by immune cell modulation

Panda, Abir K.; Bose, Sugata; Sarkar, Tania; Roy, Dia; Chakraborty, Debasis; Chakraborty, Sreeparna; Sarkar, Irene; Sa, Gaurisankar

doi:10.1007/s13237-017-0194-7

Cited by 4 publications

(2 citation statements)

References 121 publications

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“…As non-specific killer cells, NK cells can promote specific immune responses or directly kill target cells via antibody-dependent pathways. A decrease in the percentage of NK cells in the peripheral blood usually leads to a high incidence of tumors ( Vivier et al, 2012 ; Panda et al, 2017 ). In CTP-treated Apc Min/+ mice, the enhanced IL-2 and IL-12 levels were confirmed, indicating the promotion of T-cell and NK-cell activation ( Carballido et al, 2012 ; Yan et al, 2018 ), and promotion of Th1 cells’ differentiation ( Yan et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Calf Thymus Polypeptide Restrains the Growth of Colorectal Tumor via Regulating the Intestinal Microbiota-Mediated Immune Function

Zhao

Kong

et al. 2022

Front. Pharmacol.

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Calf thymus polypeptide (CTP), with a molecular mass of <10 kDa, is prepared from the thymus of less than 30-day-old newborn cattle. In the present study, the inhibitory function of CTP in colorectal cancer (CRC) was investigated in B6/JGpt-Apcem1Cin(MinC)/Gpt (ApcMin/+) mice. CTP hampered tumor development and enhanced the ratio of CD3e−NK1.1+ cells by 113.0% and CD3e+CD28+ cells by 84.7% in the peripheral blood of ApcMin/+ mice. CTP improved the richness, diversity, and evenness of the intestinal microbiota of ApcMin/+ mice, particularly by regulating the abundance of immune-related microorganisms. CTP effectively regulated the expression of immune-related cytokines, such as interleukin (IL)-2 (15.19% increment), IL-12 (17.47% increment), and transforming growth factor (TGF)-β (11.19% reduction). Additionally, it enhanced the levels of CD4 and CD8, as well as the ratio of helper T lymphocytes (Th)1/Th2 in the spleen and tumors of ApcMin/+ mice. In CTP-treated mice, reduced levels of programmed death-1 (PD-1), programmed cell death-ligand 1 (PD-L1), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), activated nuclear factor of activated T cells 1 (NFAT1), and nuclear factor κB (NF-κB) p65 signaling were noted. Collectively, the anti-CRC effect of CTP is related to the modulation of intestinal microbiota-mediated immune function, which provides a reference for CTP as a therapeutic drug or a combination drug used in CRC treatment in a clinical setting.

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Section: Discussionmentioning

confidence: 99%

Calf Thymus Polypeptide Restrains the Growth of Colorectal Tumor via Regulating the Intestinal Microbiota-Mediated Immune Function

Zhao

Kong

et al. 2022

Front. Pharmacol.

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“…In fact the cancerous system occupies the major part in this issue including cancer in immune therapy and nuclear events in cancer stem cells. A significant observation has been recorded by restoration of immune response in cancer by immune cell modulation [10]. Head and neck squamous cell carcinoma (HNSCC) is a most common and fatal cancer type affecting 30-40% of human population in India [13].…”

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confidence: 99%