Cancer-Immune Equilibrium: Questions Unanswered

Bhatia, Alka; Kumar, Yashwant

doi:10.1007/s12307-011-0065-8

Cited by 37 publications

(35 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the "equilibrium phase" tumor growth is controlled by the immune system but tumor cells are not completely eradicated. In the "escape" phase the tumor progresses and metastasizes [4,6]. The delicate balance between tumor cell growth and elimination may be disturbed by immune manipulations enhancing naturally occurring immunosurveillance.…”

Section: Introductionmentioning

confidence: 99%

Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia

Orzechowska

Chaber

Wiśniewska

et al. 2014

International Immunopharmacology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia

Orzechowska

Chaber

Wiśniewska

et al. 2014

International Immunopharmacology

View full text Add to dashboard Cite

“…A better understanding of the intricate interplay between cancer and the immune system, and of mechanisms of immune evasion and of hijacking of the host response by cancer cells, is relevant to the development of effective immunotherapeutic approaches (3)(4)(5)(6).…”

mentioning

confidence: 99%

Modeling putative therapeutic implications of exosome exchange between tumor and immune cells

Huang

Hanash

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Development of effective strategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better understanding of the contribution of the tumor microenvironment to the complex interplay between cancer cells and the immune response. Recently, effort has been directed at unraveling the functional role of exosomes and their cargo of messengers in this interplay. Exosomes are small vesicles (30-200 nm) that mediate local and long-range communication through the horizontal transfer of information, such as combinations of proteins, mRNAs and microRNAs. Here, we develop a tractable theoretical framework to study the putative role of exosome-mediated cell-cell communication in the cancer-immunity interplay. We reduce the complex interplay into a generic model whose three components are cancer cells, dendritic cells (consisting of precursor, immature, and mature types), and killer cells (consisting of cytotoxic T cells, helper T cells, effector B cells, and natural killer cells). The framework also incorporates the effects of exosome exchange on enhancement/reduction of cell maturation, proliferation, apoptosis, immune recognition, and activation/ inhibition. We reveal tristability-

show abstract

“…As aforementioned the marked decrease in 16 of 24 plasma cytokines and chemokines at day 14 correlated with an increase in pro-tumor cell types Tc, NK and NK/T cells, potentially indicating a re-activation of the immune response at this time point. We tentatively speculate that this may be associated with tumor immune escape (33), as the histological and MRI tumor growth appeared to accelerate around this time point.…”

Section: Discussionmentioning

confidence: 87%

Temporal and spatial modulation of the immune response of the murine Gl261 glioma tumor microenvironment

McKelvey

Hudson

Kumar

et al. 2019

Preprint

View full text Add to dashboard Cite

AbstractGlioblastoma, the most aggressive form of glioma, has a 5-year survival rate of <5%. While radiation and immunotherapies are routinely studied in the murine Gl261 glioma model, little is known about its inherent immune response. This study quantifies the temporal and spatial localization of immune cell populations and mediators during glioma development.Eight-week old male C57Bl/6 mice were orthotopically inoculated with 1×106 Gl261 cells and tumor morphology, local and systemic immune cell populations, and plasma cytokines/chemokines assessed at Day-0, 1, 3, 7, 14, and 21 post-inoculation by magnetic resonance imaging, chromogenic immunohistochemistry, multiplex immunofluorescent immunohistochemistry, flow cytometry and multiplex immunoassay respectively.From Day-3 tumors were distinguishable with >30% Ki67 and increased tissue vascularization (p<0.05). Increasing tumor proliferation/malignancy and vascularization were associated with significant temporal changes in immune cell populations within the tumor (p<0.05) and systemic compartments (p=0.02 to p<0.0001). Of note, at Day-14 16/24 plasma cytokine/chemokines levels decreased coinciding with an increase in tumor cytotoxic T cells, natural killer and natural killer/T cells. Data derived provide baseline characterization of the local and systemic immune response during glioma development. They reveal that type II macrophages and myeloid-derived suppressor cells are more prevalent in tumors than regulatory T cells, highlighting these cell types for further therapeutic exploration.

show abstract

Cancer-Immune Equilibrium: Questions Unanswered

Cited by 37 publications

References 58 publications

Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia

Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia

Modeling putative therapeutic implications of exosome exchange between tumor and immune cells

Temporal and spatial modulation of the immune response of the murine Gl261 glioma tumor microenvironment

Contact Info

Product

Resources

About