Cancer Health Risk Assessment of Exposure to Arsenic by Workers of AngloGold Ashanti–Obuasi Gold Mine

Obiri, Samuel; Dodoo, D.K.; Okai-Sam, F.; Essumang, David Kofi

doi:10.1007/s00128-006-0907-0

Cited by 36 publications

(16 citation statements)

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“…Carcinogenic risk is defined as the incremental probability that an individual will develop cancer during ones lifetime due to chemical exposure under specific scenarios (Chen and Liao 2006;Obiri et al 2006). For residents of Nanjing, the carcinogenic risk of As and Cd by ingestion and dermal exposure was calculated (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Preliminary Risk Assessment of Trace Metal Pollution in Surface Water from Yangtze River in Nanjing Section, China

Zhao

Jia

et al. 2009

Bull Environ Contam Toxicol

362

148

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In order to investigate the contamination levels of trace metals, surface water samples were collected from six regions along Yangtze River in Nanjing Section. The concentrations of trace metals (As, B, Ba, Be, Cd, Cr, Cu, Fe, Pb, Li, Mn, Mo, Ni, Sb, Se, Sn, Sr, V and Zn) were determined using inductively coupled plasma-atomic emission spectrometry (ICP-AES). Total concentrations of the metals in the water samples ranged from 825.1 to 950.4 microg/L. The result was compared with international water quality guidelines. Seven metals levels were above the permissible limit as prescribed by guidelines. A preliminary risk assessment was then carried out to determine the human health risk via calculating Hazard Quotient and carcinogenic risk of the metals. Hazard Quotients of all metals were lower than unity, except As. The carcinogenic risk of As and Cd was higher than 10(-6), suggesting that those two metals have potential adverse effects on local residents.

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Section: Resultsmentioning

confidence: 99%

Preliminary Risk Assessment of Trace Metal Pollution in Surface Water from Yangtze River in Nanjing Section, China

Zhao

Jia

et al. 2009

Bull Environ Contam Toxicol

362

148

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“…It is made up of four basic steps, namely: hazard identification, exposure assessment, dose-response assessment and risk characterization (Obiri et al 2006;USEPA 2001;Asante-Duah 1996).…”

Section: Risk Assessment Processmentioning

confidence: 99%

“…These toxic substances are neurotoxic, carcinogenic, nephrotoxic, mutagenic, etc. and continuous intake will affect the central nervous system, the endocrine system and kidneys of people exposed to these toxicants (Obiri et al 2006(Obiri et al , 2010Obiri 2007;Amonoo-Neizer and Amekor 1994).…”

Section: Introductionmentioning

confidence: 97%

Assessment of Non-cancerous Health Risk from Exposure to Hg, As and Cd by Resident Children and Adults in Nangodi in the Upper East Region, Ghana

Cobbina

Dagben

Obiri

et al. 2011

Water Qual Expo Health

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This study assessed non-cancerous health risk from exposure to mercury, arsenic and cadmium via oral ingestion of contaminated water bodies by resident children and adults in Nangodi, Upper East region, Ghana in accordance with US Environmental Protection Agency (USEPA). The mean concentration of arsenic, mercury and cadmium in water bodies in the study area for arsenic ranges from 0.0120 to 0.0653 mg/L; 0.0048 to 0.202 mg/L for mercury and 0.2665 to 1.090 mg/L for cadmium. These mean levels of arsenic, mercury and cadmium in water bodies from the study area were used as input parameters in calculating the non-cancerous health risk. The results of the non-cancerous health risk faced by resident children in the study area from exposure to mercury in a dug-well at Nakpadana is 6.7 via central tendency exposure parameter (CTE) and 13.0 via high end exposure parameter (HEE); in the case of arsenic we have 1.9 by CTE parameters and 3.7 by HEE parameters respectively, whilst for cadmium we had 29.0 and 58.0 by CTE and HEE parameters respectively. The non-cancerous health risk results expressed in terms of hazard quotient obtained in this study for both resident children and adults in most cases exceeded the acceptable USEPA hazard quotient value of 1.0, which suggests that resident adults and children are at high risk of showing symptoms associated with non-cancerous effects of exposure to arsenic, mercury and cadmium such as low IQ, tremor, renal failure, etc.

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“…In this study, non-carcinogenic health risk refers to harm done to the central nervous and other adverse health effects (except cancer) due to exposure to neurotoxic chemicals such as Hg and Pb. The risk assessment process is made up of four iterative steps namely, hazard identification, exposure assessment, dose-response assessment and risk characterization (Obiri et al, 2006;USEPA, 2001;Asante-Duah, 1996).…”

Section: Health Risk Assessment Processmentioning

confidence: 99%

Non-cancer risk assessment from exposure to mercury (Hg), cadmium (Cd), arsenic (As), copper (Cu) and lead (Pb) in boreholes and surface water in Tinga, in the Bole-Bamboi District, Ghana

Cobbina¹

2013

J. Toxicol. Environ. Health Sci.

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The study assessed non-cancer human health risk from exposure to mecury (Hg), cadmium (Cd), arsenic (As), copper (Cu), and lead (Pb) in surface and groundwater in Tinga, in the Bole-Bamboi District. A total of 42 water samples were collected for a period of six months. Mean concentration of Hg, Cd, and Pb were found to be (0.050 ± 0.04 mg/L), (0.031 ± 0.02 mg/L) and (0.07 ± 0.05 mg/L), respectively. These were all above the World Health Organization (WHO) recommended guideline values for drinking water. Non-cancer human health risk as a result of exposure to Hg and Cd through ingestion of borehole water was found to be high. Hazard quotients (HQ) as a result of exposure to mercury for adults and children ranged from 2.5 to 30 through central tendency exposure (CTE) and 4.6 to 60 through reasonable maximum exposure (RME). For Cd, CTE ranged from 0.96 to 2.7 and RME ranged from 1.8 to 5.4. The HQ for exposure to Hg and Cd through ingestion of ground water exceeded the acceptable United States Environmental Protection Agency (USEPA) value of 1.0. This implies that resident children and adults are likely to develop diseases (such as low intelligent quotient, tremor, kidney failure, increased hypertension and cardiovascular diseases) associated with long term exposure to Hg and Cd.

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Cancer Health Risk Assessment of Exposure to Arsenic by Workers of AngloGold Ashanti–Obuasi Gold Mine

Cited by 36 publications

References 0 publications

Preliminary Risk Assessment of Trace Metal Pollution in Surface Water from Yangtze River in Nanjing Section, China

Preliminary Risk Assessment of Trace Metal Pollution in Surface Water from Yangtze River in Nanjing Section, China

Assessment of Non-cancerous Health Risk from Exposure to Hg, As and Cd by Resident Children and Adults in Nangodi in the Upper East Region, Ghana

Non-cancer risk assessment from exposure to mercury (Hg), cadmium (Cd), arsenic (As), copper (Cu) and lead (Pb) in boreholes and surface water in Tinga, in the Bole-Bamboi District, Ghana

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