Cancer Following Treatment of an Autonomously Functioning Thyroid Nodule With Sodium Iodide I 131

Hamburger, Joel I.; Meier, Donald A.

doi:10.1001/archsurg.1971.01350120126025

Cited by 25 publications

(3 citation statements)

References 15 publications

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“…This could be due to the smaller size of the child's thyroid gland, resulting in greater rad exposure per gram tissue and could also be due to greater mitotic activity present in the young thyroid gland.67 Autonomic toxic nodules, sporadically occurring in childhood, are best treated with ~u r g e r y~"~~ and not with 1311, which probably re-sults in unavoidable radiation exposure to extranodular thyroid tissue. 70 3) Nuclear irradiation. Accidental exposure to nuclear irradiation and radioactive fallout eventually containing iodine-isotopes may lead to an increased occurrence of thyroid -7 3…”

Section: Incidencementioning

confidence: 99%

Differentiated thyroid cancer in children

Keyser

Herle

1985

Head Neck

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Differentiated thyroid cancer in children remains a controversial disease entity. Its incidence has markedly declined over the last decade since the use of radiotherapy in the treatment of benign conditions of the head, neck, and thorax was abandoned. Other etiologic factors have become relatively more important. The clinical presentation of childhood thyroid cancer is similar to that found in adults, except for a higher frequency of local and distant metastases at the time of initial diagnosis. The specificity and sensitivity of diagnostic tests are limited; however, like in adults, fine-needle aspiration compares favorably with other available diagnostic methods. The therapeutic approach to a child with thyroid cancer represents the most controversial issue associated with the disease. This review provides a discussion of the rationale for the different therapeutic options and emphasizes the excellent prognosis and survival rates, especially when patients are subjected to aggressive treatment with total thyroidectomy followed by the administration of radioactive iodine.

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Section: Incidencementioning

confidence: 99%

Differentiated thyroid cancer in children

Keyser

Herle

1985

Head Neck

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“…On the other hand, in toxic nodular goiter with highly uneven uptake these doses may be delivered to paranodular tissue. Such was probably the case of developing cancers following 13'I treatment of independent thyroid adenoma as first reported by H a m b u r g e r and M a y e r [9],…”

Section: Discussionmentioning

confidence: 82%

“…In patients treated with 131I for hyper thyroidism, doses of about 30 to 150 Gy (Gray) are usually delivered, leading to impaired cell proliferation with early or late hypothyroidism, with low risk of reproduction of radia tion induced abnormalities [8,9], The risk of developing thyroid cancer is much higher with lower doses than those delivered to thyroid in the course of external radiotherapy, c.g., thymic hyperplasia, ranging between 1 to 5 Gy [26], These doses could seldom be encountered in patients treated for Graves' disease with diffuse goiters. On the other hand, in toxic nodular goiter with highly uneven uptake these doses may be delivered to paranodular tissue.…”

Section: Discussionmentioning

confidence: 99%