Cancer-exocytosed exosomes loaded with bio-assembled AgNCs as smart drug carriers for targeted chemotherapy

Tanziela, Tanziela; Shaikh, Sana; Rehman, Fawad Ur; Semcheddine, Farouk; Jiang, Hui; Zhang, Lu; Wang, Xuemei

doi:10.1016/j.cej.2022.135980

Cited by 26 publications

(6 citation statements)

References 71 publications

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“…A novel self-assembly drug-delivery platform was synthesized after exosomes’ isolation from cell culture medium of the U87 cell line and, simultaneously, incubation with [Ag (GSH)]+ and DOX separately and combined. Studies with the aforementioned exosomes demonstrated the high-efficiency potential of silver nanoclusters (AgNCs) as smart cancer-targeting agents as compared to exosomes that lack AgNCs in parallel to high uptake and excessive ROS production with sustained DOX release in cancer cells and zero activity on normal cells [ 247 ].…”

Section: Exosomes In the Treatment Of Brain Cancermentioning

confidence: 99%

Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer

Avgoulas,

Tasioulis,

Papi

et al. 2023

Pharmaceutics

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Cancer is designated as one of the principal causes of mortality universally. Among different types of cancer, brain cancer remains the most challenging one due to its aggressiveness, the ineffective permeation ability of drugs through the blood–brain barrier (BBB), and drug resistance. To overcome the aforementioned issues in fighting brain cancer, there is an imperative need for designing novel therapeutic approaches. Exosomes have been proposed as prospective “Trojan horse” nanocarriers of anticancer theranostics owing to their biocompatibility, increased stability, permeability, negligible immunogenicity, prolonged circulation time, and high loading capacity. This review provides a comprehensive discussion on the biological properties, physicochemical characteristics, isolation methods, biogenesis and internalization of exosomes, while it emphasizes their therapeutic and diagnostic potential as drug vehicle systems in brain cancer, highlighting recent advances in the research field. A comparison of the biological activity and therapeutic effectiveness of several exosome-encapsulated cargo including drugs and biomacromolecules underlines their great supremacy over the non-exosomal encapsulated cargo in the delivery, accumulation, and biological potency. Various studies on cell lines and animals give prominence to exosome-based nanoparticles (NPs) as a promising and alternative approach in the management of brain cancer.

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Section: Exosomes In the Treatment Of Brain Cancermentioning

confidence: 99%

Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer

Avgoulas,

Tasioulis,

Papi

et al. 2023

Pharmaceutics

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“…Smart sustained drug release profiles were notably observed under acidic tumor environments, further validated by bioimaging. 147 Bio-orthogonal click chemistry involves the use of specific chemical reactions that selectively react with bio-orthogonal functional groups present in exosomes. This technique allows for precise and controlled attachment of therapeutic cargo or surface modifications to exosomes.…”

Section: Exosome-based Therapeutic Approaches For Glioblastomamentioning

confidence: 99%

“…The spherical smart nanoconjugate having an average dimension of 30–120 nm showed selective cytotoxicity against cancer targets. Smart sustained drug release profiles were notably observed under acidic tumor environments, further validated by bioimaging . Bio-orthogonal click chemistry involves the use of specific chemical reactions that selectively react with bio-orthogonal functional groups present in exosomes.…”

Section: Exosome-based Therapeutic Approaches For Glioblastomamentioning

confidence: 99%

Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis

Nag

Bhattacharya

Dutta

et al. 2023

ACS Biomater. Sci. Eng.

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Glioblastoma (GBM) is an aggressive type of cancer that has led to the death of a large population. The traditional approach fails to develop a solution for GBM's suffering life. Extensive research into tumor microenvironments (TME) indicates that TME extracellular vesicles (EVs) play a vital role in cancer development and progression. EVs are classified into microvacuoles, apoptotic bodies, and exosomes. Exosomes are the most highlighted domains in cancer research. GBM cell-derived exosomes participate in multiple cancer progression events such as immune suppression, angiogenesis, premetastatic niche formation (PMN), ECM (extracellular matrix), EMT (epithelial-to-mesenchymal transition), metastasis, cancer stem cell development and therapeutic and drug resistance. GBM exosomes also carry the signature of a glioblastoma-related status. The exosome-based GBM examination is part of the new generation of liquid biopsy. It also solved early diagnostic limitations in GBM. Traditional therapeutic approaches do not cross the blood−brain barrier (BBB). Exosomes are a game changer in GBM treatment and it is emerging as a potential platform for effective, efficient, and specific therapeutic development. In this review, we have explored the exosome−GBM interlink, the clinical impact of exosomes on GBM biomarkers, the therapeutics signature of exosomes in GBM, exosome-based research challenges, and future directions in GBM. Therefore, the GBM-derived exosomes offer unique therapeutic opportunities, which are currently under preclinical and clinical testing.

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“…Among the many metal nanoparticle photothermal materials, 19–22 copper oxide nanoparticles (CuO NPs) exhibit superior antibacterial and antiviral properties due to their unique toxicity mechanism. They have been shown to significantly inactivate bacteria and viruses such as HSV, 23 SARS-CoV-2, 24 H1N1, 25 S. aureus and E. coli .…”

Section: Introductionmentioning

confidence: 99%

Preparation and performance of a stimuli-responsive drug delivery system: novel light-triggered temperature-sensitive drug-loaded microcapsules

Chen,

Zhou,

Wei

et al. 2023

J. Mater. Chem. B

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Cancer-exocytosed exosomes loaded with bio-assembled AgNCs as smart drug carriers for targeted chemotherapy

Cited by 26 publications

References 71 publications

Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer

Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer

Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis

Preparation and performance of a stimuli-responsive drug delivery system: novel light-triggered temperature-sensitive drug-loaded microcapsules

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