Abstract:Cancer is an evolutionary process of somatic cellular selection. Genetic and epigenetic alterations in tumour cell populations generate the heritable variation on which natural selection can act. The multistep process of carcinogenesis can be rationalised as the acquisition of functional traits that enable incipient cancer cells to achieve replicative success and, eventually, immortality in a tumour microenvironment. Evolution explains why cancer exists, as it is a natural consequence of selection at the cellu… Show more
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