Cancer du sein chez la femme de 35 ans et moins au CHU de Brazzaville

Ndounga, Eliane; Bambara, Augustin Tozoula; Liboko, Alexis Fortuné Bolenga; Itoua, Clautaire; Moukassa, Donatien; Mbon, Jean Bernard Nkoua

doi:10.11604/pamj-cm.2020.2.94.20955

Cited by 2 publications

(4 citation statements)

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“…The sampling strategy was to obtain a number of cases necessary for statistical significance of the results. The size of our sample of 150 cases is closer to several studies [9,10,19,20] and significantly superior to other studies [21,22] .…”

Section: Discussionsupporting

confidence: 50%

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Malanda

Boumba

Malonga

2021

Int J Health Sci Res

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Introduction: Breast cancer is a heterogeneous disease with a variety of morphological, molecular, treatment response and clinical outcome characteristics. The objective of this work was to assess the epidemiological, histological, immunohistochemical and molecular subtypes of breast cancer in women in the Republic of Congo. Material and Methods: We carried out a cross-sectional descriptive study which took place from January 1, 2014 to December 31, 2020. The study focused on 150 cases of breast cancer in patients diagnosed at the University Hospital of Brazzaville (CHU-B). The epidemiological, clinical, histological, immunohistochemical and molecular subtypes were the variables studied. Results: The mean age was 48.09 ± 13.87 years with the extremes of 22 years and 80 years. The study of the profession; the most represented in our study was that of the cultivator 20.67%. A predominance of breast cancer localization was observed in the left breast in 47.33%. The frequency of a family history was 7.33% or 11 cases. The most frequently represented histologic type was 62% invasive non-specific type carcinoma (CITNS). The most represented histological grade was Scarff Bloom Richardson grade II (51.33%), followed by grade III 24% and grade I in 12% of cases. Regarding the results of IHC; of the 150 cases, 102 (68%) had positive hormone receptors (HR +). The ORs were positive in 102 cases (68%) while the PRs were positive in 98 cases (65.33%). The Her2 oncogene was over expressed in 38 cases (25.3%). The Ki-67 proliferation index was known for the 150 cases, including 77 (51.33%) less than 15% and 73 (48.67%) greater than or equal to 15%. The distribution of molecular subtypes was 46% luminal A, 22% triple negative, 17% luminal B and 10% Her2 +. Tumors of unknown molecular profile were 5%. The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). Conclusion: It should be noted that the association between histological and immunohistochemical diagnosis can help determine the phenotype of breast cancer, with the aim of guiding treatment and therefore improving response to treatment. Key words: Epidemiology, Histology, Immunohistochemistry, molecular subtypes, breast cancer, Republic of Congo.

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Section: Discussionsupporting

confidence: 50%

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Malanda

Boumba

Malonga

2021

Int J Health Sci Res

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“…These results are similar to those found in Congo in 2020 by Ndounga et al, who also found the disease at late stages in young women [3] who found a predominance of T2 classified tumors in patients under 40 [10] Open Journal of Obstetrics and Gynecology [11]. Furthermore, stage II of the disease was the most frequent in the study groups [11].…”

Section: Discussionsupporting

confidence: 90%

“…Women under 40 had a mortality rate of 48.3%, higher than that of women over 40 (22.4%). The mortality rate was identical to that of Ndounga et al [3] in Congo, 47% in young women compared to 18.2%. This high rate in women under 40 years of age could be due to late diagnosis, absence of hormone receptors making them refractory to endocrine treatment, high histological grade, Her2 overexpression with significant Ki67, more aggressive molecular type.…”

Section: Discussionsupporting

confidence: 80%

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Histo-Phenotypic Aspects of Breast Cancer in Women under 40 Years Old, in Yaoundé

Ngo,

Zambo,

Menye

et al. 2024

OJOG

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Introduction: Breast cancer is the most common cancer in women worldwide, with an increasing incidence. Although it is rare and no much studied in young women, it represents 7% of cases worldwide and often appears more aggressive with a poor prognosis compared to its counterpart in older women. The main objective of our study was to describe the histological and phenotypic aspects of breast cancer in women of age under 40. Methodology: We conducted a descriptive and analytical cross-sectional study, with retrospective collection of data over a period of 05 years. All women diagnosed with breast cancer were included and divided into 2 study groups: under 40 years old and over 40 years old. Data were analyzed using SPSS version 23.0 software, compared using the Chi square or Fisher exact test. A p value < 0.05 was indicative of significance. Results: We retained 196 files, either 89 for those under 40 and 107 for those over 40. Young patients with breast cancer had a higher stage, grade and tumor size. Lymph node involvement was more observed in women under 40 years (69.6% vs 53.2%). Older women were more likely to be hormone receptor positive (54.2% vs 38.2%); p = 0.018. HER-2 overexpression was higher in women younger than 40 years (39.32% vs 25.23%); p = 0.080 with a high Ki67 proliferation index (30.3% versus 2.8%); p < 0.001. Triple-negative and Her-2 tumors were much more frequent in young women (48.3% vs. 36.4%; p = 0.063) and (17.97% vs. 10.3%; p = 0.125). Conclusion: Breast cancer in young women remains more aggressive and is dominated by triple negative and Her-2 phenotypes.

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Cancer du sein chez la femme de 35 ans et moins au CHU de Brazzaville

Cited by 2 publications

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Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Histo-Phenotypic Aspects of Breast Cancer in Women under 40 Years Old, in Yaoundé

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Cancer du sein chez la femme de 35 ans et moins au CHU de Brazzaville

Cited by 2 publications

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Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Histo-Phenotypic Aspects of Breast Cancer in Women under 40 Years Old, in Yaound&#233;

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Histo-Phenotypic Aspects of Breast Cancer in Women under 40 Years Old, in Yaoundé