Cancer drug resistance related microRNAs: recent advances in detection methods

Hu, Xinyuan; Song, Zhen; Yang, Zi-Wei; Li, Jiajing; Liu, Jing; Wang, Huai-Song

doi:10.1039/d2an00171c

Cited by 9 publications

(7 citation statements)

References 150 publications

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“…Interactions among the DNA damage response, DNA repair components and miRNAs have been reported [ 39 ]. The ectopic expression of miRNAs, as regulatory factors, can interfere with the activity of DNA repair mechanisms, which have been implicated in multiple types of resistance [ 40 ]. Some miRNAs can reverse drug resistance by targeting genes encoding DDR-related enzymes [ 41 ].…”

Section: Mechanisms Of Drug Resistance In Ovarian Cancermentioning

confidence: 99%

“…4 ) collectively regulate biological processes in human malignancies and are associated with the proliferation, invasion and therapeutic resistance of cancer cells [ 94 ]. The expression of signaling pathway components can be modulated by miRNAs through miRNA–mRNA binding, typically to miRNA target sites in the mRNA 3’-UTR [ 40 , 95 ]. Although cancer-associated signaling pathways are complex, the identification of potential therapeutic targets is promising.…”

Section: Mechanisms Of Drug Resistance In Ovarian Cancermentioning

confidence: 99%

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Drug resistance in ovarian cancer: from mechanism to clinical trial

Wang,

Zhu

et al. 2024

Mol Cancer

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Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance is the bottleneck in ovarian cancer treatment. The increasing use of novel drugs in clinical practice poses challenges for the treatment of drug-resistant ovarian cancer. Continuing to classify drug resistance according to drug type without understanding the underlying mechanisms is unsuitable for current clinical practice. We reviewed the literature regarding various drug resistance mechanisms in ovarian cancer and found that the main resistance mechanisms are as follows: abnormalities in transmembrane transport, alterations in DNA damage repair, dysregulation of cancer-associated signaling pathways, and epigenetic modifications. DNA methylation, histone modifications and noncoding RNA activity, three key classes of epigenetic modifications, constitute pivotal mechanisms of drug resistance. One drug can have multiple resistance mechanisms. Moreover, common chemotherapies and targeted drugs may have cross (overlapping) resistance mechanisms. MicroRNAs (miRNAs) can interfere with and thus regulate the abovementioned pathways. A subclass of miRNAs, “epi-miRNAs”, can modulate epigenetic regulators to impact therapeutic responses. Thus, we also reviewed the regulatory influence of miRNAs on resistance mechanisms. Moreover, we summarized recent phase I/II clinical trials of novel drugs for ovarian cancer based on the abovementioned resistance mechanisms. A multitude of new therapies are under evaluation, and the preliminary results are encouraging. This review provides new insight into the classification of drug resistance mechanisms in ovarian cancer and may facilitate in the successful treatment of resistant ovarian cancer.

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Section: Mechanisms Of Drug Resistance In Ovarian Cancermentioning

confidence: 99%

Section: Mechanisms Of Drug Resistance In Ovarian Cancermentioning

confidence: 99%

Drug resistance in ovarian cancer: from mechanism to clinical trial

Wang,

Zhu

et al. 2024

Mol Cancer

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“…They affect proliferation, invasion and therapy response. Plus to revealing the role of miRNAs in drug resistance, the detection methods for miRNAs have been also introduced (Hu et al 2022).…”

Section: Mirnas In Regulation Of Carcinogenesismentioning

confidence: 99%

miRNAs as short non-coding RNAs in regulating doxorubicin resistance

Mirzaei,

Paskeh,

Moghadam

et al. 2023

J. Cell Commun. Signal.

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“…To date, a number of advanced miRNA detection methods with high specificity and sensitivity have been developed, such as chromatography-based methods and mass spectrometry-based nanomaterial-based methods. miRNA detection methods are going to focus on facilitating the development of noninvasive diagnosis and inhibiting cancer drug resistance ( 97 ). In a recent study, the combined use of microRNAs and long noncoding RNAs with chemotherapeutic compounds, as well as the induction of suicide genes, provided an innovative therapeutic approach for the management of glioblastoma (GBM) ( 98 ).…”

Section: Future Perspectivesmentioning

confidence: 99%

The role of noncoding RNAs in cancer lipid metabolism

Wang

et al. 2022

Front. Oncol.

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Research on noncoding ribonucleic acids (ncRNAs) is mostly and broadly focused on microRNAs (miRNAs), cyclic RNAs (circRNAs), and long ncRNAs (lncRNAs), which have been confirmed to play important roles in tumor cell proliferation, invasion, and migration. Specifically, recent studies have shown that ncRNAs contribute to tumorigenesis and tumor development by mediating changes in enzymes related to lipid metabolism. The purpose of this review is to discuss the characterized ncRNAs involved in the lipid metabolism of tumors to highlight ncRNA-mediated lipid metabolism-related enzyme expression in malignant tumors and its importance to tumor development. In this review, we describe the types of ncRNA and the mechanism of tumor lipid metabolism and analyze the important role of ncRNA in tumor lipid metabolism and its future prospects from the perspectives of ncRNA biological function and lipid metabolic enzyme classification. However, several critical issues still need to be resolved. Because ncRNAs can affect tumor processes by regulating lipid metabolism enzymes, in the future, we can study the unique role of ncRNAs from four aspects: disease prevention, detection, diagnosis, and treatment. Therefore, in the future, the development of ncRNA-targeted therapy will become a hot direction and shoulder a major task in the medical field.

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Cancer drug resistance related microRNAs: recent advances in detection methods

Abstract: MiRNAs are related to cancer drug resistance through various mechanisms. The advanced detection methods for the miRNAs are reviewed.

Cited by 9 publications

References 150 publications

Drug resistance in ovarian cancer: from mechanism to clinical trial

Drug resistance in ovarian cancer: from mechanism to clinical trial

miRNAs as short non-coding RNAs in regulating doxorubicin resistance

The role of noncoding RNAs in cancer lipid metabolism

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